Dr. Alexander Wong Profile picture
Feb 11, 2022 21 tweets 13 min read Read on X
Great @SaskHealth Town Hall last PM re: #COVID19 in Saskatchewan. Key points:

- Community MAY have peaked w/ Omicron.
- Non-ICU/ICU numbers STILL rising
- #SK non-ICU system capacity MAXED OUT.
- Relaxed public health measures in #SK = LONGER & MORE SEVERE Omicron wave

🧵 /1
Let's start w/ cases, non-ICU & ICU COVID patients, & deaths.

CASES (blue line) are falling. This may be artificial to degree given limited PCR testing in #SK.

HOSPITALIZED (non-ICU) patients (light green 'shade') are at HIGHEST LEVELS of pandemic, now exceeding Delta. /2
ICU patients (dark green 'shade') are rising but nowhere near levels seen w/ Delta when #SK had to fly patients to Ontario.

DEATHS (red line) are rising gradually with Omicron but remain considerably lower than #SK's Delta peak. /3
Here is the COVID-19 non-ICU census for the province presented as 7-day rolling average.

The overall numbers (green) are clearly rising. Saskatoon (orange) and Regina (yellow) are peaking but not coming down as yet.

Northern (light blue) and Rural (purple) are rising still. /4
Currently, 74 persons are occupying ICU beds in #SK.

A little over 40% are currently (+) for COVID-19. We expect these numbers to rise in the coming days as hospitalizations continue to push higher, causing ICU strain once again like w/ Delta. /5
Point of emphasis:

COVID non-ICU cases at HIGHEST levels ever across Saskatchewan.

As result, non-ICU system capacity is MAXED OUT.

So YES, @SKGov declared an end to public health measures amidst worst non-ICU system pressures thus far in pandemic across province.

Sad. /6
In a positive sign, #SK's 7-day rolling average of PCR test positivity IS declining. Slowly.

This is a more reliable indicator of where #SK is at with Omicron compared to case numbers in light of restricted PCR testing.

Test positivity peaked ~Jan 30-31, per graphic below. /7
If #SK has peaked in community end of January, we'd expect hospital & ICU admissions to peak b/w Feb 14-21, and come down thereafter, if similar to other jurisdictions.

Caveat: very relaxed / non-existent public health measures in #SK MAY cause more prolonged peak. /8
How about BA.2, which has taken over as dominant strain in some parts of world? BA.2 = 30-40% MORE transmissible vs original Omicron.

We don't know what BA.2 will do in Canada. Will it cause second peak? If so, in face of relaxed measures in #SK, could be problematic. /9
A reminder slide on what is classified as 'priority groups' for publicly-funded PCR testing in #SK:

- Hospitalized pts
- Public Health outbreaks
- Symptomatic HCWs / essential workers w/ (-) RAT
- Symptomatic in Indigenous communities
- Symptomatic w/ high-risk conditions

/10
#SK remains second-last in 1st & 2nd dose vaccine uptake in Canada, only behind Alberta.

3rd dose uptake in those 18+ & eligible is better in #SK, the province is "middle of pack".

Still LOTS of work with regards to #SK's provincial vaccine push. /11
For #SK tweens/teens b/w 12-17, 3rd doses are NOW available.

Pfizer preferentially offered over Moderna (decreased risk of myocarditis), Moderna available on request.

Must be >5 months from 2nd dose. If your teens are eligible, please GO! /12
The Critical Care Resource Allocation Framework (CCRAF) was developed in Spring 2020 amidst COVID.

Goal = save most lives possible.

During Delta, criteria MET to escalate triage stage, but MAJOR barriers occurred including "reluctance to triage", operationalization. /13
This confirms the following:

When #SK was at Delta peak & transferring #SK ICU pts to Ontario, there was CCRAF formal request to escalate triage stage.

For political reasons, this didn't "officially" occur.

Result? Bedside triage, deaths, HUGE moral distress for #SK HCWs. /14
An update on early therapies in #SK.

To date? 156 persons rec'd sotrovimab, 26 rec'd Paxlovid.

Given number needed to treat of 16 (sotrovimab) & 17 (Paxlovid) to prevent 1 hospitalization, that's ~12 hospitalizations prevented so far.

Modest impact. Can do better, IMO. /15
Summary points:

- Community transmission appears to have peaked in urban settings, rural settings unclear.
- Hospitalizations / ICU admissions still rising. Expect trend to continue in coming days.
- Impact of early therapies has been modest.

/16
Everything is where we expected them to be with modelling, except KEY difference = we have not seen anywhere near HORRIBLE numbers predicted by modelling thus far (i.e. 750-1500 in hospital).

Case peak end of Jan means hospitals/ICUs should hopefully turn around 'soon'. /17
Unknowns?

Given #SK's relaxed protection measures & revocation of ALL of measures by March 1, what impact will this have?

Will Omicron drop quickly, will BA.2 cause a resurgence?

Regardless, dropping ALL protections WAS early by any medical or public health metric. /18
I don't think anyone is debating this point any longer, but for the record, the decisions announced earlier this week to remove all public health measures WAS motivated by political ideology, NOT public health guidance or a desire to save lives & minimize suffering. /19
Sorry, short rant.

The lack of meaningful #COVID19 data @SKGov is, IMO, shameful.

If you're going to give us a weekly update, AT LEAST give us better than yesterday's garbage.

LOOK at Town Hall data. Use same approach.

Inform your citizenry to make good decisions.

/20
Take-home?

- STILL lots of community transmission. Take care, be careful.
- #SK hospital capacity is MAXED OUT.
- Don't expect #SK hospitals to turn around for 7-10 days.
- Removing public health measures WILL prolong #SK's painful Omicron wave.

Stay safe #SK.

/end

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More from @awong37

Apr 18, 2022
Latest wastewater data for #SK communities was released earlier today. It's NOT good.

Let's work through what has been going on over the last couple of weeks as BA.2 has taken complete hold across Saskatchewan.

Short 🧵 - here we go. (1/7)
Regina & Saskatoon have seen HUGE increases in wastewater viral burden since early April. It's all driven by the more contagious BA.2 Omicron variant.

@LaurenPelley tweeted last week as Saskatoon's viral burden increased an astonishing *742%*. (2/7)

As of Apr 13, Saskatoon's viral burden has increased by yet another 25%, setting a new historic record once again. Nuts.

Viral burdens are TRIPLE that of the worse levels seen with Delta last Fall. It's all BA.2 - 99.3% now. The tiny 0.7% remaining is BA.1. (3/7)
Read 7 tweets
Mar 3, 2022
Between February 1-26, 143 Saskatchewan citizens have died from #COVID19, despite Omicron being "less severe".

That's an INSANELY high number.

Saskatchewan's most deadly month thus far was October 2021, when 156 people died during our horrific Delta wave. /1
As highlighted by @DrKyle, Saskatchewan's death rate from #COVID19 is more than DOUBLE that of the 2nd highest province, Manitoba.

No province is even remotely close in terms of deaths per capita at this point with Omicron. So embarrassingly bad. /2

With 2 days left, February 2022 might not technically be Saskatchewan's deadliest month during this pandemic, but remember... there's only 28 days in February vs 31 days in October.

If you pro-rate 5.5 deaths per day (February 2022's deaths per day) x 31 days? *170* deaths. /3
Read 5 tweets
Feb 28, 2022
Hi, Saskatchewan.

Though @SKGov has now dropped all #COVID19 protections & mandates, sadly, COVID is NOT over.

#SK hospitals & ICUs remain packed.

Patients are being admitted, and dying, tragocally, eacn and every day.

A short 🧵 below for my fellow Saskatchewanians. /1
Please, be mindful of our medically vulnerable, kids under 5 who can't be vaccinated, the elderly & frail. Those who will and already face long COVID.

Respect their health and their right to live their lives as fully as possible in a manner that is safe & low-risk. /2
If your immediate response for those who are vulnerable to or anxious of COVID is, "well, just stay home"?

Remember how you felt when "others" said the same to you about mask mandates or proof-of-vaccine programs.

Let's end the divisiveness. Let's do things TOGETHER, safely. /3
Read 11 tweets
Feb 24, 2022
Weekly Saskatchewan COVID-19 data for Feb 13-19.

KEY POINTS:
- 37 deaths over 7 days. 1 b/w 20-39, all others >= 40
- Hospitalizations & ICU admissions decreasing (phew)
- Weekly test positivity 14.4% (last wk ~20%)
- ALL Omicron (no breakdown of BA.1 vs BA.2)

Brief 🧵 /1
Let's start with key data around hospitalizations & ICU admissions.

Week-by-week hospitalizations down 9% to 372, ICU down 18% to 27. Slowly coming down, thankfully.

Of those with known COVID status, 42% in hospital/ICU "due to COVID", 58% "incidental". /2
We can see that overall hospital admissions per day definitely decreasing now across all regions of Saskatchewan, but it's a relatively slow decrease, likely driven by limited protections we have in place provincially.

Still, this is reassuring and encouraging. /3
Read 15 tweets
Feb 22, 2022
Saskatchewan #COVID19 wastewater data released today for 4 #SK communities.

Both Saskatoon & Regina showing significant INCREASES in viral load week over week. Discouraging.

Reasons for increase unclear at this time. BA.2 driven?

Brief 🧵 to review #SK wastewater data. /1
Let's start with Regina.

@UofRegina wastewater analysis shows rebounding viral load levels week-over-week, suggestive of ongoing high rates of viral transmission in community.

BA.1 remains dominant but 18% BA.2 reported too. We expect BA.2 to dominate in coming days. /2 Image
Also, note that @UofRegina plot is time-lagged by 13 days, as the most recent analysis comes from the time period b/w Feb 6-12 inclusive.

So presumably proportion of BA.2 in Regina is higher now, just don't know how much higher. /3
Read 11 tweets
Feb 20, 2022
"Hi Alex, what's BA.2? Is it a little bad or is it REALLY bad?"

BA.2 is a sub-lineage of Omicron. The 'original' lineage of Omicron is designated as BA.1 & remains the dominant strain circulating in most parts of Canada currently.

A brief 🧵 of what we know thus far. /1
BA.1 & BA.2 are both classified by @WHO as Omicron, but are distinct viruses. See the phylogenetic diagram below (thx @kallmemeg).

BA.2 has over 25 mutations that differentiate it vs BA.1.

Many questions still exist around how similar BA.1 & BA.2 are clinically. /2
Danish pre-print data comparing transmission of BA.1 vs BA.2 in household settings suggests BA.2 IS more transmissible than BA.1.

BA.2 also LIKELY possess more immune-evasive properties vs BA.1 that could reduce vaccine efficacy. /3

medrxiv.org/content/10.110…
Read 20 tweets

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