Alina Chan Profile picture
Feb 13 13 tweets 4 min read
People on both sides of #OriginOfCovid agree it was risky to experiment with live SARS-like viruses at BSL2 (low biosafety) & virus hunting + manipulation possibly led to COVID.

The key difference is that one side doesn't think the lab has been transparent. The other side does.
This is why one side insists that there should be an inspection of lab records, research documents, databases etc.

Whereas the other side is willing to take it on trust that the Wuhan lab(s) did not have a SARS-CoV-2 precursor in their possession prior to the detected outbreak.
As a scientist, I am incredulous that all of the virus strains and sequences in a top research lab have already been published at any one time.

But some other scientists seem to believe it is possible for all virus strains and sequences in a lab to be in the public domain.
For example, before the EcoHealth reports were released via FOIA last year, did the public know of the specific chimeric SARS-like viruses and MERS virus being handled in the Wuhan lab in 2017-2019?

Were these strains created 2-4 years ago put in the public domain in real time?
Because the disagreement is no longer about science (we largely agree now that it is plausible that Covid-19 emerged due to research activities) but now about whether to trust someone (is the Wuhan lab being honest or not?), this argument has reached a standoff.
We wrote VIRAL compiling all of the scientific & circumstantial evidence surrounding each origin hypothesis, but there is no amount of book/article writing or tweeting, no amount of fact-checking that can "debunk" someone's unconditional trust (i.e., trust without verifying).
Vice versa, there is nothing you can say that would persuade me to believe it is acceptable to trust someone's word on the #OriginOfCovid without being able to verify it via independent and non-conflicted investigators.

Difficult to think of another situation with higher stakes.
It doesn't matter if that person is the sweetest, most unimpeachable person on earth. We still need a credible, independent, transparent, data-based investigation to be conducted.
If niceness is a 100% safeguard against research-related accidents or infections in one's research group, regardless of inappropriate biosafety level and lack of protective equipment, I have to say all research institutes have been using the wrong professor selection criteria.
This difference in trust isn't a geopolitical issue, although the stakes are higher for scientists/reporters in China compared to other countries.

If a US scientist wanted us to trust them on #OriginOfCovid without allowing an investigation, I would also be raising hell.
In fact, I'm fairly sure that if, in an alternate universe, a US scientist was the one whose group might've leaked SARS-CoV-2, their lab members and building would have been endlessly mobbed by journalists and the public.
As it is, journalists in the US, UK, Australia etc. are FOIA'ing (litigating) collaborators of the Wuhan Institute of Virology in order to find any piece of evidence in their possession that might shed light on the #OriginOfCovid
I believe they have the same investigative approach as I do: investigate with an open mind, find the data/evidence, pursue all plausible hypotheses, do not take assertions or claims on trust (even if the person is a science celebrity or says that they represent science).

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More from @Ayjchan

Feb 14
This is an archived page of the Wuhan Institute of Virology 野生动物携带病毒病原特色数据库 database backend h/t @C_Small_

It lists the date, # independent IPs, # visitors, page visits, # requests, and downloads (GB). These ground to a halt in Sep 2019.
archive.md/9MNVZ Image
@C_Small_ Interestingly, the database interface page was visited from outside of China as well during this period: Image
Unfortunately, because the database's public interface page has been removed, it's not easy to tell what was originally there.

A public description of the interface had been archived:
archive.fo/jPPkB Image
Read 11 tweets
Feb 12
I'm proud of VIRAL. @mattwridley & I had to write this book in record time, compiling months of research and fact checking the book multiple times.

Despite great efforts by natural origin proponents, they have failed to point out even a single piece of misinformation in VIRAL.
@mattwridley The largest criticisms have been that VIRAL is too technical for some readers and that it does not conclude whether SARS-CoV-2 / COVID-19 emerged naturally or due to research activities.

We can't do anything about the latter because there is no direct evidence for either origin.
One question that often comes up is how can we investigate now that 2 years has passed? Isn't this a situation where we will never know the #OriginOfCovid?

My answer is no, there are so many approaches of investigation still left unexplored. It's way too early to give up.
Read 9 tweets
Feb 9
2 early takeaways from this saga:

1. Chinese scientists asked @NIH NCBI database to delete deposited data containing sequences of early versions of SARS-CoV-2 virus.

2. US-based @biorxivpreprint blocked European scientists from posting their analysis of this data as a preprint.
Never thought I'd ask this, but... @biorxivpreprint @cshperspectives

What is bioRxiv's gatekeeping policy when it comes to original analyses? And would you consider a more transparent approach to this gatekeeping by publishing the name of the reviewer and reason for rejection?
@biorxivpreprint @cshperspectives Although bioRxiv is not a peer review service, it still confers a certain level of credibility to the preprints it has screened.

Has the team at bioRxiv considered that now there may be conflicts of interest among its screeners that should be carefully managed?
Read 5 tweets
Feb 8
An oldie but a goodie.
"Particularly sensitive is the mine shaft where the closest relative of the COVID-19 virus.. was discovered after an outbreak in 2012.. Wuhan Institute of Virology and the China CDC both studied bat coronaviruses from this shaft."
apnews.com/article/united…
I don't buy that elite scientists in China - Wuhan Institute of Virology, Chinese CDC director's lab, Beijing Institute of Pathogen Biology - scoured the Mojiang mine repeatedly over years for bat coronaviruses without thinking the miners were likely infected by a 🦇coronavirus.
These top scientists literally sampled the shit out of thousands of bats, rodents and other animals in that mine for years - testing every sample for viruses that might potentially infect humans.

And some people think they did not suspect the miners had been felled by a virus?
Read 13 tweets
Feb 8
What a difference a year can make.

March 2021:
"many virologists also remain unconvinced by the idea that SARS-CoV-2 was engineered"
buzzfeednews.com/article/petera…
May 2021:
"More investigation is still needed to determine the origin of the pandemic. Theories of accidental release from a lab and zoonotic spillover both remain viable. Knowing how COVID-19 emerged is critical..."
science.org/doi/10.1126/sc…
June 2021:
"You can't distinguish between the two origins from just looking at the sequence. So, naturally, you want to know were there people in the virology laboratory in Wuhan who were manipulating viral genetic sequences?"
caltech.edu/about/news/the…
Read 6 tweets
Feb 8
It troubles me that there are emails and documents located here in the USA which can tell us what SARS-like viruses and rare cleavage sites scientists in Wuhan had discovered.

Why are these not being subpoena'ed so that we can end speculation about #OriginOfCovid?
I keep seeing tweets about not being able to investigate the #OriginOfCovid unless the Chinese government lets us. If you think it through, there is so much info, documentation & communications scattered around the world. A lot of it here in the USA. We've known this since 2020.
The numerous scientists, many here in the US and some in other countries, who were part of the DEFUSE proposal just kept mum about their 2018 furin cleavage site insertion pipeline for nearly 2 years until some anonymous person leaked it.
Read 5 tweets

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