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Anthony J Leonardi, PhD, MS Profile picture
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Feb 19 • 4 tweets • 3 min read
drugtargetreview.com/news/81320/t-c…

Wow @VincentRK @profvrr @jwitker @drlucymcbride @yoncabulutmd

come quick!

Please debunk this Science Immunology paper on T cell exhaustion in Covid-19!
I'm one step ahead I think because in 2020 I wrote that the T cell exhaustion is a way to prevent overshooting activation ;)

But I have another one for you to debunk! frontiersin.org/articles/10.33…
frontiersin.org/articles/10.33…

I wrote this in 2020 which explains why the pd-1 is upregulated :)

But nice job with the comments on my publication and personal views :)
This science immunology paper actually says that cd8 t cells could contribute to excessive tissue damage, just like I wrote in 2020 science.org/doi/10.1126/sc…

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More from @fitterhappierAJ

Anthony J Leonardi, PhD, MS Profile picture
Feb 21
Wow scam accounts can't interpret what t cell aging means. No it doesnt mean people would drop dead from reinfections right away. What it means is there is a decompensation when control is not achieved where T cells contribute to harm via overexuberance
Don't put words in my mouth if you have a feeble understanding of immune-mediated pathology to begin with.

Idiots
The scams/frauds couldn't even remotely conceive that CD8 t cells would be contributing to harm.

More and more papers about the harm they exert

Without scientific imagination you couldnt predict it, and without a brain and eyes you dont read it doi.org/10.1016/j.cell…
Read 5 tweets
Anthony J Leonardi, PhD, MS Profile picture
Feb 19
I'd say caves are the last place we should be heading under BSL-2 conditions, especially with everyone not boosted yet.

I disagree with Vincent, boosters are necessary for all
Should we have a moratorium on Bat Cave Spelunking?
Bat viruses are natural weapons against humans in symbiosis with the bats
Read 4 tweets
Anthony J Leonardi, PhD, MS Profile picture
Feb 19
Guys please watch this video👇

Then read this new finding on exhaustion
science.org/doi/10.1126/sc…

@jwitker @VincentRK and @profvrr think my and Dr. Vijayanand's concern of T cell exhaustion is "nonsense"

I have to say some of them agreed with Todaro's opinion of herd immunity
Nevermind they get both of our opinions wrong, which is that the exhaustion is a way to prevent CD8 T cell mediated harm

They even found less cd8 exhaustion in Severe cases.

CD8s causing harm... this is a Jan 2022 publication
My publication was in 2020

I said CD8 T cells were overexuberant and causing harm, and exhaustion was a way they prevented overexuberance

I surmised that without an expensive and long study, long ago, and implicated FasL like the image above! 👆
frontiersin.org/articles/10.33…
Read 5 tweets
Anthony J Leonardi, PhD, MS Profile picture
Feb 19
This is curious. People I respect were saying immunologists do not believe reinfections or breakthroughs could devolve into long covid or harm immunity, and that my statements are too wild.

I think breakthroughs and reinfections are inconvenient truths to "Covid is over™"
There is a group of economically-prioritizing neoliberals that are strong-arming immunology to claim that these tempered statements of immunity to SARS being insufficient are false

People will get harmed in the coming waves friends, I promise you
Dropping masks and the status quo to do so is M.A.D.

Mutually Assured Destruction

Now is the time to be careful because BA.2 is out and Omicron has rapid mutagenesis compared to previous variants
Read 5 tweets
Anthony J Leonardi, PhD, MS Profile picture
Feb 19
Please, only if you know what Tem is:

Sars cov 2 reinfections may have an additive detriment to immunity
only if you know what Tem is:
Breakthrough infections may devolve into Long Covid's curious depletion
Only if you know what Tscm is:
I anticipate Long covid's curious depletion to be self limiting (without intervention)
Read 5 tweets
Anthony J Leonardi, PhD, MS Profile picture
Feb 18
People keep posting me on reddit 😂

I swear it's not me

They get really mad when you say t cells die and get depleted in SARS Cov 2 and Long Covid reddit.com/r/Immunology/c…
Don't take my word for it, just read the papers!

I will link two:
nature.com/articles/s4159…
and the second nature.com/articles/s4141…
Read 4 tweets

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