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Alexandros Marinos Profile picture
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Feb 27 • 9 tweets • 3 min read
Come on guys, give it up already. Image
Guess who jumped on this?
I'm not just being glib. Even if it is research by deeply conflicted people who are implicated in the original coverup or at least suppression of the lab leak hypothesis, and committed academic misconduct along the way, the findings should be examined.
After exhaustive review of the literature, @jonstewart has put forth the most compelling zoonosis theory. It's a low bar, but still.
"maybe a bat flew into the cloaca of a turkey..."
And for no reason whatsoever, a list of athletes who reported getting extremely ill at the 2019 Military World Games in Wuhan, a month before the first "official" case.
Also for no reason whatsoever, a video of Connor Reed, is an English teacher living in Wuhan at the time of the outbreak, the first known Brit to get COVID-19, in November 2019.
Connor died not a year later, we're told of a drug overdose, in Wales.
Tell me more about this seafood market outbreak in December 2019, I'm extremely interested about the latest research on a hypothesis that just won't die.
Lol

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More from @alexandrosM

Alexandros Marinos Profile picture
Feb 27
OK, tell me about everything dodgy about Event 201.
The first mention of Event 201 I can find on the web is on August 21, 2019. This is important because it's not implausible that a lab leak could have happened before then.

centerforhealthsecurity.org/news/center-ne…
Why was it named event 201? Ryan Morhard gives us the down-low. Image
Read 4 tweets
Alexandros Marinos Profile picture
Feb 23
I'll document this case of aggressive dishonesty from @AviBittMD as a reference for why I will no longer be engaging him in the future, as he's heavy on the insults and light on the substance.

So, he claims that my claim was false because remdesivir succeeded in a similar trial.
He contests this claim I made about the JAMA study:

"In brief, the study design was such that any other antiviral, such as Paxlovid or Molnupiravir, would also have failed."
In my second tweet, I demonstrated the problem with a helpful image:
Read 17 tweets
Alexandros Marinos Profile picture
Feb 21
A 🧵 of cases where data has been withheld or updates suspended, explicitly because the Authorities did not want the Commoners to "misunderstand" and "misinterpret" it.

As usual, I'll start with the ones I know, and please respond with more cases you are aware of.
1.
2. Scotland
Read 6 tweets
Alexandros Marinos Profile picture
Feb 20
Yes, every hypothesis should be treated with suspicion. That doesn't mean it should not be disseminated, explored, investigated etc.

Explaining the basics of science to @AviBittMD is tiresome.

This man is a DDoS agent of bad faith.

Seriously, this is the best use of your time?
Let's do this slowly for the people in the back: @BretWeinstein was commenting on a piece by Scott Alexander which picked through many ivm RCTs and did a meta-analysis to show there is a very weak signal. Then he threw the worms hypothesis on top to explain the signal.
This is a huge shift in epistemic standards. We're going from published, most peer reviewed, randomized controlled trials, many of which have been pored over by opposing groups, and trying to explain them away with a hypothesis that existed as a set of tweets. Epistemic whiplash.
Read 6 tweets
Alexandros Marinos Profile picture
Feb 19
As for my position on Ιvermectin, it's been consistent since the summer. We don't know if it works or not because *appropriately sized studies with correct dosing and timing* aren't being done. But it's safe enough that it's not worth not giving.
You can see a prior review of the evidence I did a couple of months back here, showing that there is a clear, if uncertain, signal of efficacy. doyourownresearch.substack.com/p/a-conflict-o…
The real scandal is that the proper authorities don't seem interested in drugs like this, or even fluvoxamine, which has even stronger data.

Run a trial with the same parameters as Paxlovid or Molnupiravir. It can't be impossible, it's been already done for those medicines.
Read 5 tweets
Alexandros Marinos Profile picture
Feb 19
What went wrong with the recent I-TECH Ιvermectin study published in JAMA?🧵

In brief, the study design was such that any other antiviral, such as Paxlovid or Molnupiravir, would also have failed.

This thread will explain why.
jamanetwork.com/journals/jamai…
Briefly, an antiviral started avg 5.1 days after symptom onset, with a primary endpoint that is triggered 3.1 days after start of treatment, when treatment is for 5 days, will be almost impossible to show benefit.

The avg patient didn't even have time to complete the treatment. Image
In the case of Paxlovid, the average patient in this trial would not even have been eligible to receive Paxlovid, since they would have been deemed "too late". fda.gov/media/155050/d… Image
Read 12 tweets

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