Important new work just out via @nature shows that SARS-CoV-2 is associated with (at least short-term) changes in brain structure. nature.com/articles/s4158… 1/ 
The analysis investigated brain changes in 785 UK participants (aged 51–81) imaged twice, including 401 cases who tested positive for infection with SARS-CoV-2 between their two scans, with 141 days on average separating their diagnosis and second scan. 2/
There were significant longitudinal effects when comparing SARS-2 infected and uninfected people: reduction in grey matter thickness in orbitofrontal cortex and parahippocampal gyrus, tissue damage in regions connected to olfactory cortex, and reduction in global brain size. 3/
Whether this deleterious impact on the brain of having COVID-19 can be partially reversed, or whether these effects will persist in the longer term than studied here, remains to be seen. 4/
Such potential neurological effects of SARS-CoV-2, like other coronaviruses, was anticipated at the outset of the pandemic in #ApollosArrow. 5/
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