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Anthony J Leonardi, PhD, MS Profile picture
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Mar 8 • 4 tweets • 1 min read
"Immunity wall" lol Image
"BA2 won't make another wave because it is Omicron"
"Viruses aren't chronic"

"These chronic viruses" - Rafi Ahmed
“It’s not neurotropic”

Brain proceeds to shrink

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More from @fitterhappierAJ

Anthony J Leonardi, PhD, MS Profile picture
Mar 9
Omicron reverted to reacquire the pathogenic features and now that pathogenic Omicron is kicking off a wave in a country with 97% immunity

Crazy

Did you all expect this?

If you listened to me you may have ;)
That's the good news. The bad news is that we won't have an updated vaccine in time. We update vaccines for flu every season, but not sars cov 2.
Been busy lately but I'm not a fairweather friend, friends :)

When the storm comes, you'll find me.

I'm a badweather friend ;)
Read 4 tweets
Anthony J Leonardi, PhD, MS Profile picture
Mar 9
Guys, the changes are typically irreversible, and other infections don't do this.

Yes, covid decerebrates. I've said it a long time. Even if it's mild.
As soon as the preprint dropped we were on it and the usual minimizers tried to convince it was meaningless. Balloux, JasnahKholin, SZ, because they are on the side of the economic interests that want you to unmask to gain immunity by infection

We all know that doesn't work...
A lot of idiots think that you will gain immunity against this by infection, and if you are reminded that you are getting brain damaged you won't fall into their scam, so they minimize

Ultimately you will just save on pensions if you keep getting infected
Read 5 tweets
Anthony J Leonardi, PhD, MS Profile picture
Mar 3
The publication on my EXACT opinion of T cells in Covid-19 is out

I'd like to introduce to you all the concept of feed-forward control of T cell differentiation and death

T cells act in a quorum and respond according to their context

frontiersin.org/articles/10.33…
This behavior and mechanism becomes appreciable "thanks to" a worldwide pandemic and big data

Along with @ChristosArgyrop, @adamhamdy, and @ruijhu, we describe the implications of this mechanism and its ramifications

More to come...
...But this mechanism describes HOW naive T cells can protect from cytotoxic T-cell mediated pathology

They act as dampeners for Effector differentiation and death and the cytotoxic function that comes with it.
Read 4 tweets
Anthony J Leonardi, PhD, MS Profile picture
Mar 2
A stepwise depiction of phenotypes associated with poor outcomes.

DeCandia claims Tn cells more diverse & fit, leading to protection

Brodin claims a degree of energy consumption causing poor outcomes

I claim Naive/Stem cell T cells act as "cytokine sinks" for exuberance
I implicate a feed-forward model of T cell differentiation and death, with a canonically paired negative feedback loop as is prototypically seen with natural feedforward control models. This negative feedback loop has ramifications. Image
So while Tn will quell exuberant function, Teff/Tem will deplete Tn/scm more rapidly if they interact in Lymphoid tissue. The T cells act as a quorum and Tem can slough off the Tn

Why you see depletion in LC; bystander activation and increased sloughing thanks to colocalization Image
Read 6 tweets
Anthony J Leonardi, PhD, MS Profile picture
Mar 2
Can someone please explain to this scam artist what a naive T cell subset loss means, and what longitudinal changes in the T cell phenotypes implies?

frontiersin.org/articles/10.33…

I'm so tired of these scam artists that are coopting my field.

The T cells are pathogenic as well.

nature.com/articles/s4158…
and yet another paper on t cell mediated harm
jintensivecare.biomedcentral.com/articles/10.11…
Read 6 tweets
Anthony J Leonardi, PhD, MS Profile picture
Feb 21
Wow scam accounts can't interpret what t cell aging means. No it doesnt mean people would drop dead from reinfections right away. What it means is there is a decompensation when control is not achieved where T cells contribute to harm via overexuberance
Don't put words in my mouth if you have a feeble understanding of immune-mediated pathology to begin with.

Idiots
The scams/frauds couldn't even remotely conceive that CD8 t cells would be contributing to harm.

More and more papers about the harm they exert

Without scientific imagination you couldnt predict it, and without a brain and eyes you dont read it doi.org/10.1016/j.cell…
Read 5 tweets

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