Nick Mark MD Profile picture
Mar 8 18 tweets 10 min read
Here’s a situation many of us have seen in the ICU or ED: “It looked like there was ST elevation on the monitor but when I took a 12 lead it was gone?!”

A STEMI went MIA? Here’s a #tweetorial all about why ST segments look different on monitors.

#FOAMed #FOAMcc
1/ ImageImage
First, here’s another great example of "disappearing ST elevation", from Dr. Smith’s ECG Blog @smithECGBlog

(If you don’t already you should definitely follow Dr Smith & bookmark his site; hqmeded-ecg.blogspot.com IMO it's the best site for ECGs; you can thank me later)
2/ Image
In order to understand *WHY* the ST segment looks different, we need to know how an ECG works & understand just a little bit of electronics & math.
(Don't worry, I promise no equations or circuit diagrams 🤞)
3/
First, we need to understand how an ECG works:
We use a pair of electrodes to measure the difference in electrical potential between two points on the body. We call this pair a “lead".

For example the left and right arm form lead I.

This was true in 1911 & still is in 2022.
4/ ImageImage
But there’s a problem: NOISE

Muscle movement/shivering, breathing, baseline wander, & other artifacts can interfere with the EKG signal.

All these types of NOISE would make the EKG almost useless for continuous monitoring.

But fortunately there’s a solution: FILTERING.
5/ From: Sivaraks & Ratanamaha...
Modern ECG monitors use *FILTERS* to remove much of the NOISE.

A bandpass filter allows only certain frequencies to pass:
Blocking low frequencies (<0.5Hz) removes respiration & baseline wander
Blocking high frequencies (>40Hz) removes most muscle twitches & AC interference
6/ Image
Summary:Bandpass filters remove low frequency (respiration, baseline wander) & high frequency noise (muscle twitches, AC interference, etc) so we get only a perfect clean ECG signal?

Sounds great right?

Well…there’s a catch: Removing NOISE alters the SIGNAL.
7/
To understand why FILTERS alters the signal, we need to review just a teeny bit of math:

It turns out that you can represent *any* complex waveform as a summation of simple sine waves.

For example, look how we can make a sawtooth wave by combining 15 sine waves together👇
8/
This means that even a complex ECG waveform can be made by combining a bunch of sinusoidal functions of different frequencies (or harmonics).

Check out how they Fourier transformed an ECG into harmonics then put those harmonics back together 👇
hindawi.com/journals/isrn/…
9/ ImageImage
🤓 Sidenote: the mathematical name for these sinusoidal functions is a phase vector, usually called a “phasor” for short
That means that when you get an ECG you are really just combining sinusoids, or you could say a “Set of Phasors to Sum”
💥Zing
I’ll show myself out…
10/
The problem is we *NEED* some of those high & low frequency sine waves to make a proper EKG waveform.

The bandpass filters that removed pesky noise also took out some of the signal.

➡️Thus Filtering alters the ST segments!
Checkout how a 0.5Hz filter alters the same ECG:
11/ ImageImage
🔑 Point: Because of ECG filters, the ST segment is unreliable on a *MONITORING* ECG
This is why you must always obtain a *DIAGNOSTIC* ECG to properly evaluate the ST segments.

(If I teach you only one thing, remember the memes!)
12/ ImageImage
Clinical 🥡:
MONITORING ECGs (boxes people are constantly attached to) are used continuously for *rhythm determination*
DIAGNOSTIC ECGs (the thing rolled in, often called “a 12 lead ECG”) should be used for detailed ECG interpretation including analysis of the ST segments
13/ ImageImage
In case you are wondering, this is why patients must “hold still” for diagnostic 12 lead ECGs but the monitoring ECG often looks OK despite movement.

This also explains the Hz number on the bottom left of every ECG printout.
14/ ImageImageImage
A few more details about filters in ECGs:
- *DIAGNOSTIC* ECGs are typically 0.05 to 150 Hz
- *MONITORING* ECGs are typically 0.67 to 40 Hz (sometimes 0.5 to 50 Hz); narrower frequency range means less noise but also less reliable ST segments.

medteq.net/article/2017/4…
15/
Some OR monitors have an even more filtered “surgery” mode (1-20 Hz) to remove electrical interference from Bovies

This highly filtered mode can cause some serious artifactual ST elevation as shown in this case report & reply by the manufacturer.
…-publications.onlinelibrary.wiley.com/doi/epdf/10.11…
16/ ImageImageImageImage
🥡 Summary:
-unlike diagnostic ECGs, monitoring ECGs are highly filtered to remove noise
-filtering removes noise but also alters the ST segment; don’t trust ST segments on monitoring mode ECGs!
-ALWAYS obtain a diagnostic 12 lead ECG to properly evaluate the ST segment
17/17
Bonus fact:
Modern Fancy monitors allow continuous ST segment monitoring.
These monitors measure STE/STD in realtime & display it as number.
The displayed waveform is still filtered so you can trust the numbers but NOT what the ST segment looks like.
If in doubt get a 12 lead. ImageImageImage

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More from @nickmmark

Mar 3
The FLCCC’s “data analyst” (who has no pharm training) is dosing ivermectin horse paste

Only problem: he makes a FATAL math error

A tube of horse paste contains 6gm (6080 mg) of ivermectin at a concentration of 18.7 mg/ml

@TwitterSafety suspend this guy before he kills someone
This guy actually got both calculations completely wrong.

In the ACTIV6 trial an 80 kg person receiving 0.6 mg/kg of ivermectin would receive:
80 kg * 0.6 mg/kg = 48 mg per day

(Somehow he calculated 0.24 mg so he was off by 200x; another huge error 😱)
Bottom line:
- don’t take animal meds EVER; it’s very easy to make a fatal mistake
- don’t take medical advice from a guy with zero training who can’t multiply two numbers correctly
Read 4 tweets
Mar 3
New embarrassingly bad study of ivermectin is a textbook example of “confounding by indication”

In short a retroactive database review found that people w/ COVID did worse if given remdesivir (only given to sick inpatients) than ivermectin (only given to well outpatients)🤔
1/
There are many problems with this “study”.

First it’s generous to even call it a “study.” It’s an *abstract* of a retrospective database review. The whole “article” is less than a page (see below).

It wasn’t pre-registered.

sciencedirect.com/science/articl…
2/
The methods are weird.

They found 1.7 million people w/ COVID. Out of this group they identified 1,072 who received ivermectin (not exactly widely used) & 40k who received remdesivir

The groups were very dissimilar: IVM was 10 yrs younger. They don’t report any comorbidities
3/
Read 9 tweets
Feb 12
In confronting COVID misinformation I’ve mostly focused on inpatient treatment (this is my area of experience).

Recently I saw the FLCCC Long COVID “protocol” & oh boy is this some crazy non-evidence based prescriptions: HIV meds, steroids, diuretics, & of course ivermectin…
1/
First off, Long COVID is definitely “real” & can be severe.

Many studies have found persistent changes in immune cell phenotype & function, months after COVID infection.

Many great docs (@WesElyMD & others) are actively researching long COVID to improve our understanding.
2/
What concerns me is FLCC presenting “protocols” as proven treatments for long COVID.

Throwing 20 medications (9 are prescription 🟥) at a problem with minimal (or no) evidence is irresponsible.
nature.com/articles/s4159…

As we will see, this is both unethical & likely harmful.
3/
Read 34 tweets
Feb 2
Do you want to improve working conditions for residents/fellows in WA?

The WA legislature is voting on HR1764 which would allow interest arbitration in collective bargaining.

This would go a long way towards correcting the power imbalance between administration & residents.
1/
Under the current system of negotiation, residents can *request* certain changes: safe working conditions, sufficient PPE, hazard/overtime pay, etc.

Administrators (who are often non-clinical) just say NOPE.

Because residents can’t/won’t strike they don’t have much leverage.
2/
When we formed the UWHA/@RFPU_NW resident union we spent YEARS fighting with administrators over these issues.

Ultimately we got lucky. Pressure from the city council & media attention helped us break the logjam.

There ought to be a better way.

3/
dailyuw.com/news/uw-medica…
Read 8 tweets
Feb 1
Instead of proposals to cap RN pay I’d love to see legislation that:
1️⃣mandates safe RN staffing ratios nationwide
2️⃣enacts a “50 state medical license” w/ straightforward reciprocity
3️⃣imposes limits on executive compensation for any hospital/org that bills CMS
For those doubting these reforms are possible. A couple points:

There already is a federal law calling for “adequate numbers of licensed RNs” 42CFR 482.23(b) The issue is that this is too vague.

15 states have passed laws that go further. CA & MA explicitly stipulate RN ratios
The CA law, enacted in 2004, mandates 1 RN to 5 med/surg patients & 1:2 for ICU patients.

After implementation RNs cared for one fewer patient on average. There was a decrease in hospital mortality & increased RN job satisfaction. ncbi.nlm.nih.gov/pmc/articles/P…
Read 6 tweets
Jan 21
The ivermectin crazies are now recommending hydroxychloroquine too.

Their “protocol” includes a dangerously high dose of diuretics & recommends high dose steroids in people not on supplemental O2.

This has crossed the line from (mostly) harmless nonsense to actual harm.
Supporting Evidence:

A 2021 Cochrane meta-analysis (the 🥇standard) concluded that HCQ “has little or no effect on the risk of death and probably no effect on progression to mechanical ventilation. Adverse events are tripled compared to placebo…”

cochranelibrary.com/content?templa…
A more recent meta-analysis in @NatureComms that included unpublished studies went further, concluding “that treatment with hydroxychloroquine is associated with increased mortality in COVID-19 patients”

nature.com/articles/s4146…
Read 9 tweets

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