Denison’s lab and its collaborators at the University of North Carolina (Baric) conducted the preclinical work showing that remdesivir could stop coronaviruses from replicating.
In Feb 2020, he was pretty clear that it should be given early.
In Feb 2020, he was pretty clear that it should be given early.
Later in the Q&A he said about potential trials: "if we design it to just treat those who are in the ICU, on a ventilator, then we might as well not design the trial".
So Denison, in the presence of Ralf Baric, said it clearly: remdesivir should be given early or not at all. And yet we designed trials to give it late. Exactly how they knew it couldn't work. Why?
More on the Remdesivir Riddle here:
More on the Remdesivir Riddle here:
https://twitter.com/alexandrosM/status/1493732795356626944?s=20&t=r30n2-FiTo-vQ_-PGwKrEg
Thank you to @CharlesRixey for the tip of the existence of this clip. The man is a walking encyclopedia pandemica.
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