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Chris Turnbull Profile picture
@EnemyInAState
Mar 23, 2022 • 7 tweets • 2 min read • Read on X
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Israel, BA2, Covid: ICU admissions now starting to tick up after months of steady decline since the brutal Omicron wave which had the highest ever deaths, admissions and ICU admissions of ANY WAVE EVER.
Hospital admissions also starting to uptick again after months of decline:
Cases also upticking in line with the rise in hospitalisations: though very low levels of cases so the rise is in ICU and admissions is somewhat unexpected at this point.

Test positivity is hovering around 14% currently—which implies that they are missing A LOT of cases though..
BA2 is growing to dominance in Isreal as their outbreak starts to tick up again:
Interesting to note that only last week Israel reported a new variant: a recombination of BA1 and BA2 which they claimed had been brought back by somebody travelling from abroad:
The Omicron wave in Israel was absolutely brutal—a reminder again of the record high deaths, cases, admissions:
Quite surprising to see the rise in admissions and ICU at this point—given the apparently 'only just up-ticking now' cases.

Have they got much more severe variant? definitely one to watch/

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More from @EnemyInAState

Chris Turnbull Profile picture
Apr 2
Hi everybody - sorry if I alarmed anyone - just to say I am alive still (and at least, unless they have started writing obituaries for death of your soul, multiple times over) I am still alive...
At least I am something that constitutes a broad consensus of 'alive' - though many would could (rightfully) argue with that consensus given the fact that life is so determined to kill us - especially internally with multiple never-ending attacks...
To summarise my recent absence: basically I have been dealing with an extreme seemingly never-ending series of bad of luck since my last post and became essentially too exhausted to write and I've needed a break from this as such.
Read 23 tweets
Chris Turnbull Profile picture
Feb 5
Promising New Trial Shows That Over-The-Counter Dietary Supplement Taken Cut Covid Infections By Over Half...

#longcovideBioMedicine Part of THE LANCET Discovery Science This journal Journals Publish Clinical Global health Multimedia Events About ARTICLES . Volume 102, 105042, April 2024 - Open Access Article Info V Share Set Alert C Get Rights Reprints Fig Show Outline Download Full Issue Mitoquinone mesylate as post-exposure prophylaxis against SARS-CoV-2 infection in humans: an exploratory single center pragmatic open label non-randomized pilot clinical trial with matched controls Keren Chen a - Nicholas J. Jackson a . Theodoros Kelesidis a,b Affiliations & Notes V Download PDF 99 Cit...
Very early days on this one: however, this prelimary trial indicates that this may possible be effective in preventing infection after being exposed to the virus.

Mitoquinone mesylate, '(Mito-MES) is an over-the-counter safe diet supplement that can be immediately available in humans in the setting of high-grade exposure to SARS-CoV-2...Evidence before this study An ongoing important need exists to rapidly develop novel therapeutics for COVID-19 that will retain antiviral efficacy in the setting of rapidly evolving SARS-CoV-2 variants and potential future development of resistance of SARS-COV-2 to remdesivir and protease inhibitors. To date, there is no FDA-approved treatment for post-exposure prophylaxis against SAR-CoV-2. We have shown that the mitochondrial antioxidant mitoquinone/mitoquinol mesylate (Mito-MES), a dietary supplement, has antiviral activity against SARS-CoV-2 in vitro and in SARS-CoV-2 infected K18-hAC...
....our real-world proof-of-concept open label exploratory clinical trial, suggests that Mito-MES may represent a rapidly applicable post exposure prophylaxis treatment against development of severe SARS-CoV-2 infection.'
Read 29 tweets
Chris Turnbull Profile picture
Jan 30
Study: Air Purifier Use At Daycare Centres Cut Kids' Sick Days By A Third...

'Use of air purifiers at two daycare centres in Helsinki led to a reduction in illnesses and absences among children and staff'

#covid #flu #tb yle Etusivu Venäjän hyökkäys UMK25 Taitoluistelun EM-kisat News Top stories Latest About us More v Science Study: Air purifier use at daycare centres cut kids' sick days by a third The results of the study at two Helsinki daycare centres are still preliminary but promising, a researcher says.
This is so basic, it's really criminal that clean air has not been implemented since before the pandemic even: none the less, another study showing the significant health benefits of cleaner air: Use of air purifiers at two daycare centres in Helsinki led to a reduction in illnesses and absences among children and staff, according to preliminary findings of a new study led by E3 Pandemic Response. Air purifiers of various sizes and types were placed in two of the city's daycare centres during cold and flu seasons. The initial results from the first year of research are promising, according to researcher Enni Sanmark, from HUS Helsinki University Hospital. "Children were clearly less sick in daycare centres where air purification devices were used - down by around 30 percent,...
Pretty basic study with clear results in line with what is expected with the basic intervention of air purification:

'Air purifiers of various sizes and types were placed in two of the city's daycare centres during cold and flu seasons.'
Read 10 tweets
Chris Turnbull Profile picture
Jan 4
Study Warns That Co-Infection With Covid & Human Metapneumovirus (hMPV) (The Virus Currently Being Blamed For The Out-Of-Control Surge In China) Can Be Highly Fatal In Kids

'SARS‐CoV‐2 in coinfection with human metapneumovirus (hMPV) in three SARS‐CoV‐2‐infected dead children.'Report of death in children with SARS-CoV-2 and human metapneumovirus (hMPV) coinfection: Is hMPV the trigger? Seyed-Ahmad Hashemi, Saghar Safamanesh 2, Hamed Ghasemzadeh-Moghaddam 2, Majid Ghafouri 1, Mina- sadat Mohajerzadeh-Heydari 3, Hasan Namdar-Ahmadabad 2, Amir Azimian 2, Author information Article notes > Copyright and License information PMCID: PMC7436913 PMID: 32767680 1. INTRODUCTION In late 2019, a new virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2) led to many cases of severe respiratory tract infection in China. This virus was belonged to the Co...
The current surge in China is officially being blamed on a combination of viruses, including Covid and the often cited human metapneumovirus (hMPV):
Read 15 tweets
Chris Turnbull Profile picture
Dec 16, 2024
New Study Shows Air Pollution Increases Severity & Fatality Of Covid

'Pollution and SARS-CoV-2 (Covid) pandemic are the greatest environmental health issues worldwide,' warns study

Luckily N95 masks, HEPA filters etc protect against both...PM2.5 SARS-CoV-2 Virus infection Spike/ACE binding ACE ACE2 OH production ROS Internalization MAPK pathway IL-6, TNF-a COVID-19 ACE2 ACE/ACE2 1 Lung injury
A new study published in the Journal Of Hazardous Materials has found that exposure to PM2.5 particles increases the severity of Covid in multiple ways: ELSEVIER Journal of Hazardous Materials Available online 15 December 2024, 136887 In Press, Journal Pre-proof HAZARDOUS MATERIALS What's this? The influence of PM2.5 exposure on SARS-CoV-2 infection via modulating the expression of angiotensin converting enzyme II Meng-Wei Lin Ting-Hsuan Wu Show more V + Add to Mendeley https://doi.org/10.1016/j.jhazmat.2024.136887 7 Jia-Rong Chang Cheng-Han Lin Chih-Sheng Lin a b 9 Hua-Hsin Chiang Share 55 Cite Get rights and content A Highlights . PM2.5 is a plausible environmental transmission carrier for SARS-CoV-2. . Air pollutants PM2....
Inhaling PM2.5 size particles (pollution)- the largest of these particles are roughly around 30x smaller than a human hair - is widely recognized itself to have a number of severe health effects: including causing dementia and a range of serious lung diseases: PM2.5, or fine particulate matter, is a term used to describe particles in the air that are 2.5 microns or less in diameter. PM2.5 is a type of particulate matter (PM), which is made up of microscopic solid or liquid droplets that can be inhaled and cause health issues. PM2.5 is a subset of PM10, which refers to particles that are 10 microns or less in diameter. PM2.5 particles are so small that thousands of them can fit on the period at the end of a sentence, and the largest PM2.5 particles are only about 30 times smaller than a human hair. PM2.5 can cause a number of adverse health effe...
Read 14 tweets
Chris Turnbull Profile picture
Dec 16, 2024
Covid antibodies shown to INCREASE severity of infection, reinfection and Long Covid:

Nice herd immunity project they got going isn't it? Some of the worst effects of the virus come from the antibodies produced to it:
'This review focuses on the Fc receptor-dependent ADE of cytokine production induced by anti-nucleocapsid antibodies( 1 of 3 mechanisms), examining its potential role in severe COVID-19 during reinfection and its contribution to the post-acute sequelae of COVID-19(LC).'
Describing Antibody Dependant Enhancement (ADE) in Sars 2, which we have talked about many times before and is not unlike the well noted ADE seen in Sars 1. Antibody-dependent enhancement (ADE), sometimes less precisely called immune enhancement or disease enhancement, is a phenomenon in which binding of a virus to suboptimal antibodies enhances its entry into host cells, followed by its replication.(1][2] The suboptimal antibodies can result from natural infection or from vaccination. ADE may cause enhanced respiratory disease, but is not limited to respiratory disease.(3] It has been observed in HIV, RSV, and Dengue virus and is monitored for in vaccine development.[4] Technical description In ADE, antiviral antibodies promote viral infectio...
Read 5 tweets

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