Chris Turnbull Profile picture
Mar 23, 2022 7 tweets 2 min read Read on X
Israel, BA2, Covid: ICU admissions now starting to tick up after months of steady decline since the brutal Omicron wave which had the highest ever deaths, admissions and ICU admissions of ANY WAVE EVER.
Hospital admissions also starting to uptick again after months of decline:
Cases also upticking in line with the rise in hospitalisations: though very low levels of cases so the rise is in ICU and admissions is somewhat unexpected at this point.

Test positivity is hovering around 14% currently—which implies that they are missing A LOT of cases though..
BA2 is growing to dominance in Isreal as their outbreak starts to tick up again:
Interesting to note that only last week Israel reported a new variant: a recombination of BA1 and BA2 which they claimed had been brought back by somebody travelling from abroad:
The Omicron wave in Israel was absolutely brutal—a reminder again of the record high deaths, cases, admissions:
Quite surprising to see the rise in admissions and ICU at this point—given the apparently 'only just up-ticking now' cases.

Have they got much more severe variant? definitely one to watch/

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More from @EnemyInAState

Feb 5
Promising New Trial Shows That Over-The-Counter Dietary Supplement Taken Cut Covid Infections By Over Half...

#longcovideBioMedicine Part of THE LANCET Discovery Science  This journal  Journals  Publish  Clinical  Global health  Multimedia  Events  About  ARTICLES . Volume 102, 105042, April 2024 - Open Access  Article Info V  Share  Set Alert  C  Get Rights  Reprints  Fig  Show Outline  Download Full Issue  Mitoquinone mesylate as post-exposure prophylaxis against SARS-CoV-2 infection in humans: an exploratory single center pragmatic open label non-randomized pilot clinical trial with matched controls Keren Chen a - Nicholas J. Jackson a . Theodoros Kelesidis a,b  Affiliations & Notes V  Download PDF 99 Cit...
Very early days on this one: however, this prelimary trial indicates that this may possible be effective in preventing infection after being exposed to the virus.

Mitoquinone mesylate, '(Mito-MES) is an over-the-counter safe diet supplement that can be immediately available in humans in the setting of high-grade exposure to SARS-CoV-2...Evidence before this study  An ongoing important need exists to rapidly develop novel therapeutics for COVID-19 that will retain antiviral efficacy in the  setting of rapidly evolving SARS-CoV-2 variants and potential future development of resistance of SARS-COV-2 to remdesivir and protease inhibitors. To date, there is no FDA-approved treatment for post-exposure prophylaxis against SAR-CoV-2. We have shown that the mitochondrial antioxidant mitoquinone/mitoquinol mesylate (Mito-MES), a dietary supplement, has antiviral activity against SARS-CoV-2 in vitro and in SARS-CoV-2 infected K18-hAC...
....our real-world proof-of-concept open label exploratory clinical trial, suggests that Mito-MES may represent a rapidly applicable post exposure prophylaxis treatment against development of severe SARS-CoV-2 infection.'
Read 29 tweets
Jan 30
Study: Air Purifier Use At Daycare Centres Cut Kids' Sick Days By A Third...

'Use of air purifiers at two daycare centres in Helsinki led to a reduction in illnesses and absences among children and staff'

#covid #flu #tb yle  Etusivu  Venäjän hyökkäys  UMK25  Taitoluistelun EM-kisat  News  Top stories  Latest  About us  More v  Science  Study: Air purifier use at daycare centres cut kids' sick days by a third The results of the study at two Helsinki daycare centres are still preliminary but promising, a researcher says.
This is so basic, it's really criminal that clean air has not been implemented since before the pandemic even: none the less, another study showing the significant health benefits of cleaner air: Use of air purifiers at two daycare centres in Helsinki led to a reduction in illnesses and absences among children and staff, according to preliminary findings of a new study led by E3 Pandemic Response.  Air purifiers of various sizes and types were placed in two of the city's daycare centres during cold and flu seasons.  The initial results from the first year of research are promising, according to researcher Enni Sanmark, from HUS Helsinki University Hospital.  "Children were clearly less sick in daycare centres where air purification devices were used - down by around 30 percent,...
Pretty basic study with clear results in line with what is expected with the basic intervention of air purification:

'Air purifiers of various sizes and types were placed in two of the city's daycare centres during cold and flu seasons.'
Read 10 tweets
Jan 4
Study Warns That Co-Infection With Covid & Human Metapneumovirus (hMPV) (The Virus Currently Being Blamed For The Out-Of-Control Surge In China) Can Be Highly Fatal In Kids

'SARS‐CoV‐2 in coinfection with human metapneumovirus (hMPV) in three SARS‐CoV‐2‐infected dead children.'Report of death in children with SARS-CoV-2 and human metapneumovirus (hMPV) coinfection: Is hMPV the trigger?  Seyed-Ahmad Hashemi, Saghar Safamanesh 2, Hamed Ghasemzadeh-Moghaddam 2, Majid Ghafouri 1, Mina- sadat Mohajerzadeh-Heydari 3, Hasan Namdar-Ahmadabad 2, Amir Azimian 2,  Author information Article notes > Copyright and License information  PMCID: PMC7436913 PMID: 32767680  1. INTRODUCTION  In late 2019, a new virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2) led to many cases of severe respiratory tract infection in China. This virus was belonged to the Co...
The current surge in China is officially being blamed on a combination of viruses, including Covid and the often cited human metapneumovirus (hMPV):
Read 15 tweets
Dec 16, 2024
New Study Shows Air Pollution Increases Severity & Fatality Of Covid

'Pollution and SARS-CoV-2 (Covid) pandemic are the greatest environmental health issues worldwide,' warns study

Luckily N95 masks, HEPA filters etc protect against both...PM2.5  SARS-CoV-2  Virus infection  Spike/ACE binding  ACE  ACE2  OH  production  ROS  Internalization  MAPK pathway  IL-6, TNF-a  COVID-19  ACE2  ACE/ACE2 1  Lung injury
A new study published in the Journal Of Hazardous Materials has found that exposure to PM2.5 particles increases the severity of Covid in multiple ways: ELSEVIER  Journal of Hazardous Materials Available online 15 December 2024, 136887 In Press, Journal Pre-proof  HAZARDOUS MATERIALS  What's this?  The influence of PM2.5 exposure on SARS-CoV-2 infection via modulating the expression of angiotensin converting enzyme II Meng-Wei Lin Ting-Hsuan Wu  Show more V  + Add to Mendeley  https://doi.org/10.1016/j.jhazmat.2024.136887 7  Jia-Rong Chang  Cheng-Han Lin Chih-Sheng Lin a b 9  Hua-Hsin Chiang  Share  55 Cite  Get rights and content A  Highlights  . PM2.5 is a plausible environmental transmission carrier for SARS-CoV-2.  . Air pollutants PM2....
Inhaling PM2.5 size particles (pollution)- the largest of these particles are roughly around 30x smaller than a human hair - is widely recognized itself to have a number of severe health effects: including causing dementia and a range of serious lung diseases: PM2.5, or fine particulate matter, is a term used to describe particles in the air that are 2.5 microns or less in diameter. PM2.5 is a type of particulate matter (PM), which is made up of microscopic solid or liquid droplets that can be inhaled and cause health issues.  PM2.5 is a subset of PM10, which refers to particles that are 10 microns or less in diameter. PM2.5 particles are so small that thousands of them can fit on the period at the end of a sentence, and the largest PM2.5 particles are only about 30 times smaller than a human hair.  PM2.5 can cause a number of adverse health effe...
Read 14 tweets
Dec 16, 2024
Covid antibodies shown to INCREASE severity of infection, reinfection and Long Covid:

Nice herd immunity project they got going isn't it? Some of the worst effects of the virus come from the antibodies produced to it:
'This review focuses on the Fc receptor-dependent ADE of cytokine production induced by anti-nucleocapsid antibodies( 1 of 3 mechanisms), examining its potential role in severe COVID-19 during reinfection and its contribution to the post-acute sequelae of COVID-19(LC).'
Describing Antibody Dependant Enhancement (ADE) in Sars 2, which we have talked about many times before and is not unlike the well noted ADE seen in Sars 1. Antibody-dependent enhancement (ADE), sometimes less precisely called immune enhancement or disease enhancement, is a phenomenon in which binding of a virus to suboptimal antibodies enhances its entry into host cells, followed by its replication.(1][2] The suboptimal antibodies can result from natural infection or from vaccination. ADE may cause enhanced respiratory disease, but is not limited to respiratory disease.(3] It has been observed in HIV, RSV, and Dengue virus and is monitored for in vaccine development.[4]  Technical description In ADE, antiviral antibodies promote viral infectio...
Read 5 tweets
Dec 15, 2024
Covid Outbreak 'Almost Derailed' Wicked Movie Infecting Main Stars Ariana Grande & Cynthia Erivo Days Before Their 'Biggest Musical Numbers'

Infectious Grande said:

'I was recovering from COVID, and my first and only time having COVID was the week of (the song) 'Popular'.' Cynthia Erivo and Ariana Grande Each Contracted COVID Days Before Their Biggest Wicked Musical Numbers Elphaba's "Defying Gravity" and Glinda's "Popular" were almost derailed by sickness, Cynthia Erivo and Ariana Grande revealed  By Jack Smart | Published on November 6, 2024 04:45PM EST  COMMENTS  f  X
'Elphaba’s “Defying Gravity” and Glinda’s “Popular” were almost derailed by sickness, Cynthia Erivo and Ariana Grande...There was one time when I got Covid, there was another time when she got Covid,” Erivo, 37, revealed' Cynthia Erivo and Ariana Grande on Oct. 19. PHOTO: EMMA MCINTYRE/GETTY  Cynthia Erivo and Ariana Grande had their work cut out for them filming Wicked. And the COVID-19 pandemic didn't help.  "There was one time when I got Covid, there was another time when she got Covid," Erivo, 37, revealed to The New York Times in an interview published Wednesday, Nov. 6.  Not only that, recalled Grande, 31, but each actress contracted the virus in the days before filming their biggest musical numbers: Erivo, who plays Elphaba, future Wicked Witch of the West, sings the climactic act one closer...
Expanding on the outbreak: Grande revealed that she was suffering from Covid on the set itself:

'I was recovering from COVID, and my first and only time having COVID was the week of 'Popular'... yahoo!news  News  Yahoo Originals  Local News  Weather  TV + Celebrity  Fact check  Crime  Science & Tech  Royals  Motori  BANG SHOWBIZ  Ariana Grande reveals she was suffering from COVID on the set of Wicked  BANG Showbiz Sat 14 December 2024 at 1:00 am GMT . 2-min read
Read 16 tweets

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