With the new #Covid_19 variant #XE taking rounds in news recently, here’s a thread briefly explaining the spectrum of mutations and their structural context. (1/4)
3 recombinant lineages (XD, XE and XF) currently been monitored and reported.
▫️XD and XF - Delta + BA.1
▫️XE - BA.1 + BA.2
▫️Initially reported from England
▫️Also found circulating in Ireland
(2/4)
github.com/cov-lineages/p…
▫️XD and XF - Delta + BA.1
▫️XE - BA.1 + BA.2
▫️Initially reported from England
▫️Also found circulating in Ireland
(2/4)
github.com/cov-lineages/p…
Most #XE recombinant genomes are found to carry 28 spike mutations, 21 of which were found in both BA.1 and BA.2, 6 of which were found in just BA.2.
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(3/4)
A quick glimpse of the structural context of spike protein shows a vast majority of variants possess resistance to various mAbs as seen in #Omicron. More information on immune evasion can be found at clingen.igib.res.in/esc/
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