1/9
Tuesdays Tweetorial:
You are in cardiothoracic theatre doing a mitral valve replacement for severe MR

The anaesthetic consultant is doing a TOE and keeps saying 'PISA'

U know its in Italy but have no idea why he keeps saying it

What is PISA and why is it used?
2/9
PISA = Proximal Isovelocity Surface Area

Blood is ejected -> LA

It converges at the mitral regurgitant orifice it forming hemispheres -> different blood velocity in each hemisphere

RCCs that are equidistant from the orifice(in each hemisphere) travel at similar speed
3/9
Each hemisphere has a radius

The radius that matters for calculations is the one where aliasing occurs (where color changes from blue to red or red to blue)
Remember:
Blue: RCCs moving Away from probe
Red: Towards the probe
4/9
Why does this color change occur?

Color Doppler is similar to pulse wave Doppler so is dependent on US sampling rate

If blood flow is too fast it cannot tell which direction it is flowing in so aliasing occurs
5/9
What is the velocity where aliasing occurs called?

->Nyquist limit = PRF/2

PRF = Pulse repetition frequency = no. of US pulses sent per second
6/9
SO when the Nyquist limit (velocity where aliasing occurs) is exceeded

Blood appears to flow in the opposite direction like the wagon wheel in the old westerns
7/9
Why do we reduce the Nyquist limit to assess MR?

By reducing the velocity where aliasing occurs - we INCREASE the PISA radius

This allows us to measure the radius of the hemisphere more accurately

PISA radius at 50cm/s vs 40cm/s

Radius at 40=MUCH larger

Image from BSE:
8/9
The volume flow rate of the MR jet is calculated:

VRF = 2 x π x r2 x Aliasing velocity

We therefore need to ensure the radius is measured accurately as we SQUARE the result

So a larger radius is easier to measure accurately!

MR can graded using the following equations:
9/9
So now you know

PISA measurement isnt that complicated!
#echofirst

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More from @GUH_ICU_Anaesth

Mar 15
Quiz answer:

1.Sir Austin Bradford Hill

2.The Bradford Hill Criteria – 1965

Guidelines to help assess whether an observed association between an exposure and an outcome is likely to be causal.

#FOAMed #MedTwitter
1.TEMPORALITY:

Exposure MUST occur before outcome
This is the only absolute criteria for proving a causal relationship

Reverse causality – when outcome occurs before exposure (can be an issue with cross sectional studies)
2.Strength of the association
Measured by Odds/risk or rate ratio
A strong association is unlikely to be affected by unrecognised bias/confounding
Read 7 tweets
Nov 16, 2021
ANSWER:
A patient is admitted hypotensive with E. Coli sepsis.

The consultant asks for gentamycin and adds:

"Please don't under-dose"

Why is the initial dose of gentamycin so important?
Gentamycin, like other aminoglycosides exhibit concentration dependent killing

The initial phase of rapid bacterial killing is induced
by passive ionic binding of the drug to bacterial lipopolysaccharide.

The killing rate is directly related to
initial drug concentration
A second phase of slower bacterial killing is associated with decreased energy-dependent uptake of the aminoglycoside

This rate is independent of the initial drug level
Read 5 tweets
Sep 28, 2021
1/8
You are asked to preoperatively assess a patient with known primary severe mitral regurgitation for an hip replacement

Which of the following new findings might result in you postponing surgery:

Dilated LV
Impaired LV sys fxn
Pulmonary HTN
New Afib Image
2/8

Answer:

Any/all of the above

If known severe MR – these are the NEW findings that should prompt you to speak to you friendly cardiologist colleagues Image
3/8

Valvular Heart Dx (VHD) AHA guidelines : Image
Read 9 tweets
Sep 14, 2021
1/13 - GUH Echo tweetorial:

The tricuspid regurgitation jet velocity shown was used in a critical care patient to estimate RV systolic pressure:
Vol control – tvol 420ml PEEP 10cmH20
Cardiovascular: MAP 67mmHg on Noradrenaline 0.3mcg/kg/min
2/13
His TRVmax is high:
Why should I not diagnose this patient with pulmonary hypertension in my echo report?

2 are correct:
a. not steady state
b. Off axis cursor
c. Echo cannot diagnose it
d. Poor 2D view
3/13
Answer:
a, c and possibly b!

Lets start with what TR vmax means and how it is calculated
Read 14 tweets
Sep 14, 2021
GUH Images in Anaesthesia and ICU:

The tricuspid regurgitation jet velocity shown was used in a critical care patient to estimate RV systolic pressure:

Vol control – tvol 420ml PEEP 10cmH20

Cardiovascular: MAP 67mmHg on Noradrenaline 0.3mcg/kg/min
His TR Vmax suggests his RV systolic pressure is 51mmHg + RA pressure = HIGH

I am conscious that I should not diagnose this patient with pulmonary hypertension in my echo report:

Why?
Read 4 tweets
Jun 24, 2021
1/14
GUH - Echo Tweetorial - Aortic Stenosis:

How do they calculate:
1. Valve area
2. Mean AV gradient
3. Max AV gradient
2/14
Essential Principles:
1. The effective orifice area is always smaller than the anatomical orifice area
This effective orifice area is what is calculated
It is the key determinant of survival
2. Continuity equation
Conservation of mass
3/14
Continuity equation:
A2 X V2 = A1 x V1
(AVA) x (AV VTI) = (LVOT CSA) x (LVOT VTI)
AVA = [(LVOT CSA) x (LVOT VTI)]/ AV VTI
Read 15 tweets

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