Thread by @elisaperego78

On the "new" hepatitis in children |prof Perno in @Corriere formally notes prior SARS-CoV-2 infection and #LongCovid as possible causative factors

A role might be played by the prolonged immune ~ inflammatory dysfunctions known in Long Covid

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corriere.it/salute/malatti…

Prof. Perno also notes prior SARS-CoV-2 infection in a number of cases known worldwide: even if acute SARS-CoV-2 viral infection is gone, the hepatitis could be a "new" manifestation in #LongCovid [a note: we know covid-related hepatitis has already been reported in children]

This is presented as a working hypothesis, of course [a note: I do believe the role of #LongCovid ~ covid ~ prior SARS-CoV-2 infection should be a key, topical avenue of investigation, but I also report specifically on the interview to prof. Perno as in @Corriere]

Infection with adenovirus F41 is also obviously addressed, as there has been wide discussion of it being found in some children. Prof. Perno notes [as many had] that adenovirus F41 is generally not associated with "acute", severe hepatitis. But other factors may intervene here

There is also mentioned the "lockdown hypothesis" as diminished contacts with pathogens could bring a recrudescence now [a note: I do personally find part of/this questionable, and I hope it's not exploited for political reasons, but again I report on the article's interview]

Prof. Perno also notes that the wide spread in different continents of a completely new, unknown pathogen is unlikely, given frequency, timing, number of cases reported (for now) overall, etc.

While adenovirus F41 is found in a percentage of children with the "new" hepatitis, prof. Perno notes, there is no clear causative link between the two. Adenovirus F41 can be found also in "healthy" people. It is unlikely to cause severe disease in people who are immonocompetent

Adenovirus F41, thus, could be most directly linked to the hepatitis in a situation like: for example, the child being severely immunocompromised | and/or in the context of a prior SARS-CoV-2 infection ~ #LongCovid

Prof. Perno doesn't exclude the hypothesis of some pathogens being slightly mutated genetically to become more "aggressive" while noting (as I mentioned already) that the international spread of a "new" pathogen in view of the data we have now, is unlikely

@LongCovidKids @TigressEllie

@0bj3ctivity

Vaccination is not implicated as most or all children were not vaccinated especially the little ones of course