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Why is cranial nerve 6 uniquely affected by⬆️ intracranial pressure? Why is it special? A common question after the CN6 tweetorial.
Here is a maybe #tweetorial, but maybe a🧵about why CN6 is alone affected by ⬆️ pressure. #FOAMed#medtwitter#Medstudenttwitter#neurotwitter
2/ Think of the intracranial CSF space like a balloon, distended by CSF instead of air. Cranial nerves begin inside the balloon, and then they exit as they begin their extradural portion
3/ Most cranial nerves move immediately away from the CSF space after they exit—usually going out through their respective foramina. However, CN6 uniquely runs along the outside of the “balloon” in Dorello canal
4/ Increased intracranial pressure is like expanding the balloon. Most cranial nerves are not affected by the expanded balloon because they move away from the surface of the balloon right after they exit
5/ However, because of the unique course of CN6 along the surface of the “balloon” in Dorello canal, the increased intracranial pressure or expanding “balloon” pushes against the extradural portion of CN6
6/ Unfortunately, CN6 has nowhere to go to escape this increased pressure, as on the other side of it is the clivus. So in the increased pressure pushes it against the clivus in Dorello canal
7/ This makes a “CN6 sandwich”! CN6 gets sandwiched between clivus & dura. It's this compression that uniquely gives you an isolated CN6 palsy w/⬆️pressure!
So when you see an isolated CN6 palsy in intracranial hypertension, think of balloons & sandwiches & you’ll remember why!
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Brain MRI anatomy is best understood in terms of both form & function.
Here’s a short thread to help you to remember important functional brain anatomy--so you truly can clinically correlate!
2/Let’s start at the top. At the vertex is the superior frontal gyrus. This is easy to remember, bc it’s at the top—and being at the top is superior. It’s like the superior king at the top of the vertex.
3/It is also easy to recognize on imaging. It looks like a big thumb pointing straight up out of the brain. I always look for that thumbs up when I am looking for the superior frontal gyrus (SFG)
If the patient is symptomatic & the greatest stenosis from the plaque is >70% of the diameter of normal distal lumen, patient will likely benefit from carotid endarterectomy
But that doesn’t mean the remaining patients are just fine!
3/Yes, carotid plaques resulting in high-grade stenosis are high risk
But assuming that stenosis is the only mechanism by which a carotid plaque is high risk is like assuming that the only way to kill someone is by strangulation.
1/My hardest thread yet! Are you up for the challenge?
How stroke perfusion imaging works!
Ever wonder why it’s Tmax & not Tmin?
Do you not question & let RAPID read the perfusion for you? Not anymore!
2/Perfusion imaging is based on one principle: When you inject CT or MR intravenous contrast, the contrast flows w/blood & so contrast can be a surrogate marker for blood.
This is key, b/c we can track contrast—it changes CT density or MR signal so we can see where it goes.
3/So if we can track how contrast gets to the tissue (by changes in CT density or MR signal), then we can approximate how BLOOD is getting to the tissue.
And how much blood is getting to the tissue is what perfusion imaging is all about.