Due to the current outbreak of monkeypox in Western countries, I thought it would be good to review the clinical and pathology of this rare disease. More below.
#monkeypox #pathology #dermpath #dermatology
#monkeypox #pathology #dermpath #dermatology
Previously, monkeypox outbreaks were zoonotic from monkeys or rodents. The current outbreak is human-to-human. Currently, most cases are homosexual males with genital skin lesions.
Incubation period of 1-2 wks, followed by fever, headache, backache, and vomiting. Skin lesions start as macules, then vesicles, papules, pustules, and crusts.
Source of photo: ncbi.nlm.nih.gov/pmc/articles/P…
Source of photo: ncbi.nlm.nih.gov/pmc/articles/P…
Pathology of skin lesion: Intraepidermal necrotic, hemorrhagic blister, with balloon cell necrosis and eosinophilic cytoplasmic inclusions (Guarnieri bodies, B-type inclusions).
Photo:
mdpi.com/2306-7381/1/1/…
Photo:
mdpi.com/2306-7381/1/1/…
Differential of intraepidermal blisters with balloon cell necrosis, from dermwiz.com :
* Hand-foot-mouth disease
* PLEVA
* Erythema multiforme
* Irritant contact
* Hydroa vacciniforme
* Necrolytic migratory erythema
and many more.
* Hand-foot-mouth disease
* PLEVA
* Erythema multiforme
* Irritant contact
* Hydroa vacciniforme
* Necrolytic migratory erythema
and many more.
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