Rajiv Sarin MD Profile picture
Jun 9 10 tweets 5 min read
Media Sensation on Rectal Cancers vanishing with Immuno drug Dostarlimab without Surgery/Radiatn/Chemo
Its a signal getting brighter but 1 among many wins of #CancerResearch that needs unlimited Public support & resources/ facilitation from Govt/Charities pubmed.ncbi.nlm.nih.gov/35660797/ ImageImageImage
It's neither the 1st nor will it be the last spectacular win of cancer research against one of the several hundred forms or subtypes of human cancers

100+ y ago, early-stage Breast/ Thyroid/ Kidney/ Oral/ Stomach & other cancers then considered fatal were cured by surgery alone
80+ y ago, skin cancers, early-stage cervix, oral and larynx cancers were magically cured by Radiotherapy/Radium alone

50+ y ago, cure rates for childhood cancers, Leukemia, Lymphoma skyrocketed with chemotherapy

40+ y ago, incurable germ cell tumors cured by platinum chemo
40+ y ago combining Radiatn+Chemo cured many cancers without life changing surgery
Permanent colostomy for anal cancer became history after this historical study by Norman Negro
Millions of Lives, Breasts, Limbs, Organs & Functions are saved each yr by multimodality & Adjuvant Rx Image
20+ y ago, Targeted Therapy started hitting targets laid bare by decades of Basic Research

#Gleevac curing #CML, a dream come true & a defining moment for researchers & patients

Few types of fatal stage IV Melanomas, Lung, Breast, GI, other cancers, Lymphoma now tamed for yrs
10+ y Cancer Immunotherapy counters cancer's trick to evade body's immunity
#ImmuneCheckpointInhibitors melt cancers with high tumour mutation burden from Inherited/ Acquired alterations in DNA MisMatchRepair genes or from carcinogens

#CAR-TCell in refractory Leukaemia Lymphoma
The sober reality after 125 yrs of #CancerResearch #Breakthroughs

Stage 3/4 cancers remain quite common

Most Stage 4 cancers incurable

Many Stage 3 cancers re-occur or spread after treatment

Many Stage1/2 cancers in LMIC have poor Access/Affordability to timely & quality care Image
Many of the 10Million cancer deaths are avoidable
Every patient should demand why there are no research studies to improve outcomes for patients like them?
It will give wings to academic researchers to engage with Industry/Govt/Regulators on patient's behalf
Yes Demand = Supply
Backbone of eeach breakthrough in this🧵were scientists, technologists, doctors, geneticists in Univ/Hosp on salaries below their MarketValue, doing experiments, treatments, analysis with limited Govt/Charity research funds. They can deliver more but only with huge public support

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More from @RajivSarin5

Feb 4, 2021
Important @ICMR statement on evidence based use of #StemCell Therapy based on critical review of literature & claims by large panel of academic clinicians, which I had the privilege to lead. #StemCells often hyped & shouldn't be offered as #StandardOfCare
Inherent public appeal of #StemCellTherapy is being exploited & promoted unethically as a #MagicRemedy to vulnerable patients & should be regulated. There are many diseases where Basic/Translational/Clinical Research can establish its utility @ISSCR @ICMR @fda @ema leads the way!
Acutely aware that patients & their groups want freedom to try whatever might help them & detest when the academic medical community or regulators are so hung up on #RiskBenefitRatio & good evidence and till then say this therapy they cannot take outside regulated clinical trials
Read 7 tweets
Apr 25, 2020
Why politicians or others can promote HCQ/Other stuff as GameChanger while we just watch. They know MDs/Academics haven't yet made public understand the meaning/relevance of
Though its a public health crisis, we can't expect the public to understand the critical importance of these terms as we do in Medicine/Regulatory Agencies. COVID is not the 1st or last public health crisis. Let's try to make people know & ask about these as their rights & safety
We can engage and educate the public using examples they can relate to or remember. If they get it right they will be less gullible, esp during public health crisis
#ClinicalTrial Phase 1-3
Read 10 tweets

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