Thread by @RajivSarin5

Media Sensation on Rectal Cancers vanishing with Immuno drug Dostarlimab without Surgery/Radiatn/Chemo
Its a signal getting brighter but 1 among many wins of #CancerResearch that needs unlimited Public support & resources/ facilitation from Govt/Charities pubmed.ncbi.nlm.nih.gov/35660797/

It's neither the 1st nor will it be the last spectacular win of cancer research against one of the several hundred forms or subtypes of human cancers

100+ y ago, early-stage Breast/ Thyroid/ Kidney/ Oral/ Stomach & other cancers then considered fatal were cured by surgery alone

80+ y ago, skin cancers, early-stage cervix, oral and larynx cancers were magically cured by Radiotherapy/Radium alone

50+ y ago, cure rates for childhood cancers, Leukemia, Lymphoma skyrocketed with chemotherapy

40+ y ago, incurable germ cell tumors cured by platinum chemo

40+ y ago combining Radiatn+Chemo cured many cancers without life changing surgery
Permanent colostomy for anal cancer became history after this historical study by Norman Negro
Millions of Lives, Breasts, Limbs, Organs & Functions are saved each yr by multimodality & Adjuvant Rx

20+ y ago, Targeted Therapy started hitting targets laid bare by decades of Basic Research

#Gleevac curing #CML, a dream come true & a defining moment for researchers & patients

Few types of fatal stage IV Melanomas, Lung, Breast, GI, other cancers, Lymphoma now tamed for yrs

10+ y Cancer Immunotherapy counters cancer's trick to evade body's immunity
#ImmuneCheckpointInhibitors melt cancers with high tumour mutation burden from Inherited/ Acquired alterations in DNA MisMatchRepair genes or from carcinogens

#CAR-TCell in refractory Leukaemia Lymphoma

The sober reality after 125 yrs of #CancerResearch #Breakthroughs

Stage 3/4 cancers remain quite common

Most Stage 4 cancers incurable

Many Stage 3 cancers re-occur or spread after treatment

Many Stage1/2 cancers in LMIC have poor Access/Affordability to timely & quality care

Many of the 10Million cancer deaths are avoidable
Every patient should demand why there are no research studies to improve outcomes for patients like them?
It will give wings to academic researchers to engage with Industry/Govt/Regulators on patient's behalf
Yes Demand = Supply

Backbone of eeach breakthrough in this🧵were scientists, technologists, doctors, geneticists in Univ/Hosp on salaries below their MarketValue, doing experiments, treatments, analysis with limited Govt/Charity research funds. They can deliver more but only with huge public support

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