Dr Aditya Ganguly Profile picture
Jun 18 10 tweets 3 min read
1) As an intern, GP or a gen med resident, you are constantly exposed to MR imaging of the brain. This is a complicated imaging modality that requires a radiologist for optimum analysis and reporting. But you must know the basic sequences and how to identify them.
2) The five most common sequence that we use in internal medicine are the T1 (with or without contrast), T2, FLAIR, DWI and ADC sequences. SWI/GRE sequences are also used in certain cases.
3) First check whether the soft tissue of the scalp and the skull (black) are visible or not --> if yes, you are dealing with T1,T2 or FLAIR.
4) If the white matter (WM) is brighter than gray matter (GM) --> T1 --> visualization of vessels at the cortical surface --> T1+C
5) If WM is darker than GM --> check CSF --> if CSF is bright --> T2.

If CSF is dark --> FLAIR (this is because the FLAIR sequence is nothing but a T2 with a 180 deg RF pulse to render CSF black --> this makes the periventricular demyelination of MS easier to see!
6) Look at these 3 images and confirm what I just told you.
7) If the soft tissue of the scalp is not clearly visible, it is most likely diffusion weighted imaging. If CSF is dark --> DWI and if CSF is bright --> ADC.
8) This is NOT the way radiologists report MRI sequences --> this is an empirical way to recognize the MRI sequences in day to day practice --> for junior doctors.

This will also help you in several image based NEET PG questions.
9) I am greatly indebted to @drdevrad for teaching me a lot of radiology in the past 3 years --> this is an empiric sequence recognition technique I have adapted from his teaching.

For any questions regarding MRI technology, please refer to him!

#MedTwitter
10) Not a radiologist by profession, so some mistake might have crept in inadvertently. All opinions are welcome :)

#radiology
#MRI
#neuroimaging

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More from @AdiG1993

Jun 19
1) Have you ever seen a case of rabies?

I saw two cases 5 years back and they have stayed with me since.

I do not fear any disease per se but I am not ashamed to say that I dread rabies --> it is a terrible affliction.
2) The first patient was a small child of around 7 years old --> he had been bitten by a street dog around 1 month back. But his family had opted for natural healers.

When he was brought in, he was crying uncontrollably with a terror stricken expression on his face.
4) The delirium worsens over a period of hours to days as the patient gradually lapses into a coma, if the autonomic storm doesn't kill him or her first.

Rarely, the patients may develop a form of ascending paralysis mimicking GBS --> paralytic rabies.
Read 13 tweets
Jun 17
1) Bell's palsy (BP) is typically defined as an IDIOPATHIC unilateral LMN type CN7 palsy.

It is named after the Scottish neurophysiologist, Charles Bell. (vide infra)
2) But an LMN type CN 7 palsy is NOT the same as Bell's palsy.

It is merely the idiopathic form, often thought to be due to herpes or varicella induced direct nerve damage or as post infectious demyelination.
3) There are certain RED FLAGS in the diagnosis of an LMN type CN 7 palsy.

1. Vesicles on the tympanic membrane or ear canal (Ramsay Hunt syndrome type 2)

2. Bilateral involvement - Lyme disease, sarcoid, GBS, Melkersson-Rosenthal syndrome, Mobius syndrome etc!
Read 12 tweets
Jun 17
1) The Agnipath recruitment scheme has spawned chaos aross states --> but it is symptomatic of a larger problem.

The system of pension is economically unviable in the long term --> lifespans have increased disproportionate to retirement ages across economies.
2) Visual capitalist has created an illustrative infographic to explain this particular problem --> they call this the financial equivalent of climate change!
visualcapitalist.com/pension-time-b…
3) There are only three outcomes possible

1. Pension systems will cease to exist.
2. People will have to continue working into their 90s.
3. The reproductive rates will have to go down as most people go childless --> but this will slow down in the economy decades hence.
Read 5 tweets
Jun 10
1) I was recently contacted by a young man who was unsure of pursuing NEET since he had a tumor during his preparatory phase which had badly derailed his studies.

He was worried that he had lost 'a lot of time' and that his peers were far ahead of him!
2) I told him something I had learnt from one of my mentors long back --> No plan in life, as in war, survives first contact with the enemy!
3) This is his life and his glory or his failure will be his alone --> he has faced what others (including myself) could not have dreamt of --> in my opinion, he is a warrior!
Read 4 tweets
Jun 8
1) Cephalosporins are a commonly used class of antibiotics --> what's not so commonly known is that some members of this drug class can cause major bleeding complications!

4 groups of cephalosporins have been implicated in this problem!
2) This is based on the different side chains attached to position 3 of the cephem nucleus!
The first and largest group is the NMTT (N-methylthiotetrazole) side chain containing group --> cefamandole, cefotetan, cefmatazole, moxalactam and cefoperazone!
3) Other groups include MTDT and HTT side chain containing cephalosporins as well as cefoxitin which doesn't have any side chains attached to the 3 position of the cephem nucleus!
Read 10 tweets
Jun 6
The youngest STEMI (heart attack) patient I ever saw was aged 23.
He was obese, hypertensive,never excercised and drank soft drinks everyday! He had lost his father and uncle to STEMI as well! We suspected FH but there was no evidence!

Young age no longer rules out ACS!
FH --> Familial hypercholesterolemia, the most common AD genetic disease --> problems with the LDL receptor --> your liver cannot clear LDL --> LDL laden cholesterol gets oxidized (more in Indians, African Americans and Hispanics) --> atherosclerosis!
Statins usually work by reducing HMG CoA reductase which helps in cholesterol synthesis in the liver --> so the liver draws in more chol. from the LDL in blood using LDL receptors. They may/may not work in FH, depending on how badly the receptors are affected.
Read 6 tweets

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