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Susan Hopkins Profile picture
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Jun 20 • 8 tweets • 5 min read
🎈🎈Happy Birthday #SIRENStudy - the study opened 2 years ago & recruited ~45,000 healthcare workers for follow- up to study the impact of #COVID19 prior infection on re-infection; it then was modified to discuss the impact of #vaccination and #variants

ukhsa.blog.gov.uk/2022/06/20/the…
Highlighting key papers
SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)
The Lancet 397 (10283), 1459-1469
ncbi.nlm.nih.gov/pmc/articles/P…
COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study
The Lancet 397 (10286), 1725-1735
ncbi.nlm.nih.gov/pmc/articles/P…
@Susannajd @Thushan_deSilva T-cell and antibody responses to first BNT162b2 vaccine dose in previously SARS-CoV-2-infected and infection-naive UK healthcare workers: a multicentre, prospective study
Lancet Microbe 2021 [from our PITCH Collaborators]
sciencedirect.com/science/articl…
Protection against SARS-CoV-2 after Covid-19 vaccination and previous infection
New England Journal of Medicine 386 (13), 1207-1220

nejm.org/doi/full/10.10…
SIREN protocol: Impact of detectable anti-SARS-CoV-2 on the subsequent incidence of COVID-19 in 100,000 healthcare workers: do antibody positive healthcare workers have less reinfection than antibody negative healthcare workers?
[in press]
Determinants of SARS-CoV-2 anti-spike antibody levels following BNT162b2 vaccination: cross-sectional analysis of 6,000 SIREN study participants
medrxiv.org/content/10.110…
And lots more coming....
We couldn't do it without you , the study participants, the research teams in NHS organisations, the funders (@NIHRresearch @UKRI_News @DHSCgovuk @UKHSA) and our collaborators in PITCH, HICC, Crick, G2P, and many more -
Thank You and Happy Birthday

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More from @SMHopkins

Susan Hopkins Profile picture
May 24
monkeypox - a short thread.
Firstly a huge thank you to the people coming forward with symptoms, clinicians that are taking samples and helping us find cases, health advisors and health protection teams for tracing contacts, vaccination teams and inpatient management teams 👏
I want to add an additional thanks to organisations supporting us getting the message out in the best way possible @BASHH_UK @BritishHIVAssoc @THTorguk @Grindr and all other professionals who are working on Twitter and through their social contacts.
This infection is transmitted through close contact and sex is definitely close contact. People who identify as gay or bisexual and other men who have sex with men (who can identify their sexuality in any way they like) are the most commonly affected.
Read 8 tweets
Susan Hopkins Profile picture
Jan 8
I lead the #SIRENStudy and have been studying the impact of prior infection with COVID-19 and COVID-19 vaccinations on immunity for more than 18 months. We have published multiple studies with collaborators. The most recent preprint is available here medrxiv.org/content/10.110… 1/6
In this pre-print, which is under peer review, we demonstrate that 2 doses of vaccination on top of prior of infection, significantly reduces both asymptomatic & symptomatic infection compared to infection alone - Table 3 - the longer since primary infection the more effect 2/6
This is on top of the evidence provided in the original paper showing immunity 81-87% immunity with the original strains and early alpha period.... but just as immunity wanes from vaccines so it does from primary infection. 3/6
pubmed.ncbi.nlm.nih.gov/33844963/
Read 6 tweets

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