Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
Wong yujun Profile picture
@wong_yujun
Jun 22, 2022 • 5 tweets • 7 min read • Read on X
Scrolly
🔥Liver support system by Dr Faouzi Saliba

🌉to transplant

Plasma exchange
✅Transplant-free survival
✅Ongoing RCT (APACHE trial)

⛔️Not for those beyond #ACLF-3

#ILC2022 #Livertwitter @EASLnews @EASLedu Image
Plasma exchange in:
✅ HBV-ACLF
✅ ALF

#ACLF #ILC2022 @EASLedu ImageImage
🔥Hepatocyte transplant by Dr Anil Dhawan

✅Human hepatocytes
✅Children with ALF (n=8)
👉Alginate microencapsulated, peritoneal transplantation

Read more:👉doi.org/10.1016/j.jhep…

#ILC2022 #Livertwitter @EASLnews @EASLedu @Apichatka @jturnesv @aelsharkawy75 @LiverNotFighter Image
🔥Liver stem cells by Dr Fotios Sampaziotis

🤩Amazing advances field of liver/biliary cell

Biliary repair:
- Limited tx option
- Retrograde injection of biliary stem cells👇

#ILC2022 @EASLnews ImageImageImage
Liver renegeration by Dr Pierre Clavien

- Increase portal vein inflow
- 2-stage hepatectomies
- metabolic stimulation (regeneration-associated steatosis)
- Integrated perfusion machine
👉10.1038/s41587-019-0374-x

#ILC2022 @aelsharkawy75 @EASLnews ImageImageImage

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with Wong yujun

Wong yujun Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @wong_yujun

Wong yujun Profile picture
Jun 26, 2022
#LiverTwitter
Look forward to the last #portalhtn session in #ILC022 - starting now

Approach to fundal varices with ⭐️@JuanAbraldes @ggarciatsao @VirginiaHdezGea
🔊8am, Hepato Arena

@EASLedu @EASLnews @Sanchit30497977 @AtoosaRabiee @BrettEFortuneMD @MattiasMandorf1
1⃣Primary prophylaxis of GV #ILC2022
✅Bleeding (Glue > NSBB)
✅Decompensation (NSBB > Glue)
⛔️TIPS/BRTO as prevention

Consider:
👉Proximity to care
👉Liver function (CTP-C vs A)
👉Local expertise
👉Potential transplant

#LiverTwitter @JuanAbraldes @VirginiaHdezGea @ggarciatsao
2⃣GV bleeding in CTP-B9

⭐️Imaging - define anatomy of SPSS/PVT
🏅TIPS > Glue + NSBB:⏬rebleeding

✅EUS-guided therapy⏬rebleeding/recurrence

✅BRTO:
👍liver function
😦worsen varices/ascites -> try spleninc embolization

#LiverTwitter @JuanAbraldes @VirginiaHdezGea
Read 5 tweets
Wong yujun Profile picture
Jun 25, 2022
🔥PPI in liver-related outcome in @Cirrhosis by @nadimmahmud

🏥Comp cirrhosis, VOCAL cohort, IPTW adjst

👉PPI exposure:
⏫Severe infection (SBP), decomp
💀Mortality (⏬prior BGIT ; ⏫ liver-related💀)

✅Use PPI when indicated

#LiverTwitter @EASLnews @serperm @KaplanDeLiver
🔥NITs for CSPH in #HCV post-SRV by @GeorgSemmler #ILC2022

n=324 HCV, HVPG>6mmHg + paired LSM/Plt
CSPH resolved 25%

✅LSM>25kPa: CSPH
✅LSM<12k + Plt>150: exclude CSPH
✅3-yr decomp risk: 0% vs 9.6% (CSPH)

#LiverTwitter @SaSi_Lens @jaumebosch9 @MattiasMandorf1 Image
🔥 Important study!
⭐️Carvedilol + Simvastatin in sys inflammation by Dr Edilmar A Tapias #ILC2022 👏

n=82 cirrhosis with HRV
RCT, 1:1, CV + Sv vs CV
🎯HVPG, inflammation at 1m

⭐️Carvedilol reduce IL-6 AND HVPG
⭐️Simva enhance response

#LiverTwitter @anna_baiges @EASLnews
Read 5 tweets
Wong yujun Profile picture
Jun 25, 2022
#AIH treatment by Dr Christina Weiler-Normann #ILC2022

👉Definition of endpoints:
✅Complete response: Normal ALT & IgG (<6m)
⛔️Non-response: <50% down in ALT (<4w)
🎯Remission: HAI<4/18 (12m)

#LiverTwitter @joostphdrenth @EASLedu @EASLnews @AutoImmuneLiver @analleo
#AIH treatment by Dr Christina Weiler-Normann #ILC2022

Be aware of AEs:
👉Doctors underestimate AEs in patients (60% with steroid)
✅A lower dose steroid may be as good

🤔PROs as #AIH endpoints in future?

#LiverTwitter @joostphdrenth @analleo @EASLedu ImageImage
AS-AIH treatment by Dr Elenora De martin #ILC2022

🔮Response predictors:
Who?
👉Labs-INR/MELD
✅Radiological (Liver volume, cirrhosis?)
⛔️Clinical (HE 3-4, ascites)

💀Identify non-responder: SURFASA score: Day 3-7
✅Bactrim prophylaxis

#LiverTwitter @joostphdrenth @EASLnews ImageImage
Read 5 tweets
Wong yujun Profile picture
Jun 25, 2022
💩Gut microbiome in 🍺 by @Bernd_Schnabl

✅Untargeted:
Bugs as Drug: FMT, Probiotics:⏬ cravings @theliverdr
Drug the Bug: Rifaximin DOI: 10.1111/liv.15207

✅Targetted:
Bugs as Drug: engineered bacteria⏫IL-22

#LiverTwitter @aelsharkawy75 @jturnesv @EASLnews
#Livertwitter:

🔥How often doRare you do liver biopsy for #alcoholic hepatitis?

#ILC2022
@EASLedu @EASLnews @theliverdr @Sanchit30497977 @nipun29j @markakismd @aelsharkawy75 @jturnesv @rabataller @MATHURINPHILIP1 @MarkThursz @MorenoChristop8
✅Liver biopsy for #alcohol hepatitis
- Avoid misclassification (decomp vs alc hep)
- Avoid unnecessary steroid
- Precise fibrosis staging

⛔️Liver biopsy for🍺 hep
-? Reproducible biopsy (k<0.7)
- Access to biopsy
- Clinical diagnosis maybe as 👍

Whats' your take?😄#ILC2022
Read 6 tweets
Wong yujun Profile picture
Jun 25, 2022
🔥NIT among #NAFLD in T2DM by @JeromeBoursier #ILC2022

n=1,051 biopsy-proven NAFLD
6 NITs - NFS, FIB4, VCTE, Fibrotest, Fibrometer & blood+VCTE
✅Performance⏬in T2DM

✅Approach:
- non-T2DM: FIB4 -> VCTE
- T2DM: VCTE / Fibrometer > Fibrometer

#LiverTwitter
🤔Impact on #NAFLD/NASH trials?
👍Enrich-approach in patient selection

#ILC2022 @EASLedu @EASLnews #LiverTwitter @IanARowe @DrLoomba @NASH_and_coffee
🔥MEFIB vs MAST vs FAST to detect #NAFLD >F2 by @DrLoomba at #ILC2022

✅n=563 biopsy-proven NAFLD
Sig fibrosis 51.2%, DM 50%
🎯AUROC using rule-in/out criteria

🏆MEFIB > MAST or FAST to identify F2 NAFLD

#LiverTwitter @EASLnews @EASLedu
Read 4 tweets
Wong yujun Profile picture
Jun 24, 2022
#ILC2022 @EASLedu @EASLnews @ebtapper @BloomPringle @Apichatka @markakismd @MartaBAfonso @LouisHSLau @jlouissaint89 @ajay_duseja @salvatore_piano
🔥#ACLF-3: early vs late transplant @JosephAlukal

👉UNOS database: n=3,498
✅Better 90-day and 1-year survival for early LTx (<7 days)
🤔 Selection bias who goes for early vs late LTx?

#ILC2022 #Livertwitter @EASLedu @EASLnews
@VinaySundaramMD @RajivJalan1 @DrLiver @ebtapper
🔥Urine NGAL predicts response to Terlipressin/albumin in HRS by Dr Carmine Gambino

N=162 #cirrhosis, 🇮🇹
AKI>48hrs
urine NGAL:
⏫ ATN-AKI
⬇️ in Terli responders
💡NGAL>220 predict 90-day Mortality (AUROC: 0.85)

#ILC2022 #Livertwitter @salvatore_piano @ProfPaoloAngeli
Read 7 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

Send Email!

:(