Share this page!

Dr Elisa Perego Profile picture
Twitter logo
Jun 24 • 4 tweets • 2 min read
"Mild/severe" for covid was initially based on respiratory symptoms only and the risk of developing respiratory failure. Covid can, easily, be a severe disease. It can be deceptive, as life-threatening problems like "silent hypoxia" or coagulopathy might be pauci-symptomatic
Vaccination status, the variant from which you are infected, prior immunity, your health status etc. can make a difference in short- and long-term outcomes. But covid overall is not a mild disease. It caused one of the most devastating pandemics in human history
One of the first publications in the world openly tackling the narrative around "mild covid" here by @felicitycallard | out in May 2020

somatosphere.net/2020/mild-covi…
#MildCovid was one of the first hashtags covid patients used ironically in early 2020 to underline how public and medical descriptions of "mild" didn't really capture the reality of the disease people were experiencing

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with Dr Elisa Perego

Dr Elisa Perego Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @elisaperego78

Dr Elisa Perego Profile picture
Jun 25
Analysis of nearly 1 million Danish health records found that patients who tested positive for SARS-CoV-2 were, later, more likely to be diagnosed with Alzheimer’s disease, Parkinson’s disease, and stroke.

Easy-to-read review of new study

#LongCovid

sciencefocus.com/news/covid-19-…
The role of viral and other infections as potential triggers/ drivers/ contributors to Alzheimer's disease is a topic of great discussion in biomedical research | e.g.

ncbi.nlm.nih.gov/pmc/articles/P…
Strokes and other cerebrovascular conditions are well documented in acute and #LongCovid | e.g.

pubmed.ncbi.nlm.nih.gov/33103610/
Read 4 tweets
Dr Elisa Perego Profile picture
Jun 25
I am somewhat suspicious the folks at the unmasked #LongCovid seminar below aren't discussing fibrosis, hypoxemia, thrombosis, myocardial ischaemia, multi-organ damage, micro-clotting, pulmonary embolism, premature death? Otherwise, they wouldn't be so cavalier about their masks
And yes, all of the above is attested in #LongCovid including fatal events down the disease course
Increased risk of death and multidimensional sequelae in #LongCovid including in young people with "mild" disease at onset | @Nature | VA sample | out in spring 2021

nature.com/articles/s4158…
Read 12 tweets
Dr Elisa Perego Profile picture
Jun 25
A decent recap on omicron evolution in @Nature

But this .. ehm .... how many times was it said and the opposite happened?

"one possible future for SARS-CoV-2 is that it will become like the other 4 seasonal coronaviruses ....

nature.com/articles/d4158…
....the levels of which ebb and flow with the seasons, usually peaking in winter and typically reinfecting people every three years or so"

We are actually seeing multiple reinfections in a short time span and a summer wave. With a lot of deaths and #LongCovid

It's not a "cold"
More importantly, for our situation now

"BA.4 and BA.5 carry their own unique mutations, including changes called L452R and F486V in the viral spike protein that might tweak its ability to latch onto host cells and skirt some immune responses."
Read 4 tweets
Dr Elisa Perego Profile picture
Jun 24
Ferritin levels in #LongCovid. Some long-term patients report low levels 🧵
Looking into some studies | this 2021 in @FrontiersIn shows multiple abnormal parameters, including higher serum ferritin levels, raised ddmer. It's ~2 months in #LongCovid i.e. closer to "acute" / "hyperinflammation" phase | 75 patients | hospitalized

frontiersin.org/articles/10.33…
High levels of ferritin in the early phase of #LongCovid | 2020

"Alterations of iron homeostasis can persist for at least 2 months after the onset of covid and are closely associated with non-resolving lung pathologies and impaired physical performance."

respiratory-research.biomedcentral.com/articles/10.11…
Read 6 tweets
Dr Elisa Perego Profile picture
Jun 24
This whole thread with comments. NHI/US top researchers complaining about how difficult solving #LongCovid is.
Sorry to be blunt NHI! All early information on Long Covid was provided by patients themselves working in horrible health conditions with no funding

🧵

h/t @Dakota_150
Patients, often left at home in life-threatening conditions in early 2020, pierced together their symptoms, signs, medical data. They showed covid wasn't a mild, short respiratory illness even in the young. Many paid for their own clinical tests, which led to key discoveries
This includes the cardiovascular aspects of #LongCovid, coagulopathy, autoimmunity, hypoxia, arthritis etc.
With all due respect, if the NHI with a 1 + billion dollars endowment can't do better, maybe time for new researchers, new projects, new leaders?
Read 4 tweets
Dr Elisa Perego Profile picture
Jun 23
As *we* in advocacy have said a hundreds of times, most people don't even know #LongCovid exists. Most aren't "scared" at all: policy makers didn't inform the public about the long-term effects of SARS2. This is because, otherwise, people wouldn't complain with mass infection
The reality in-depth scientific evidence paints is actually much darker than analysis of codes and healthcare databases shows. Of course, I want to be clear. I don't mean everyone is dropping dead after SARS-CoV-2 infection! Not everyone will have severe symptoms
Not everyone will develop life-threatening covid-related sequelae or will become disabled. But some will. Many will remain with subclinical ("silent") vulnerabilities that could lead to severe events or disease later in life

#LongCovid
Read 9 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(