Thread by @wong_yujun

#AIH treatment by Dr Christina Weiler-Normann #ILC2022

👉Definition of endpoints:
✅Complete response: Normal ALT & IgG (<6m)
⛔️Non-response: <50% down in ALT (<4w)
🎯Remission: HAI<4/18 (12m)

#LiverTwitter @joostphdrenth @EASLedu @EASLnews @AutoImmuneLiver @analleo

#AIH treatment by Dr Christina Weiler-Normann #ILC2022

Be aware of AEs:
👉Doctors underestimate AEs in patients (60% with steroid)
✅A lower dose steroid may be as good

🤔PROs as #AIH endpoints in future?

#LiverTwitter @joostphdrenth @analleo @EASLedu

AS-AIH treatment by Dr Elenora De martin #ILC2022

🔮Response predictors:
Who?
👉Labs-INR/MELD
✅Radiological (Liver volume, cirrhosis?)
⛔️Clinical (HE 3-4, ascites)

💀Identify non-responder: SURFASA score: Day 3-7
✅Bactrim prophylaxis

#LiverTwitter @joostphdrenth @EASLnews

(cont by Dr Elenora De Martin)
⭐️Acute AIH subtypes (jaundice? INR>1.5? HE?)

2nd line tx:
✅Tacrolimus, DOI: 10.1002/hep.24141
✅Cyclosporin, DOI: 10.1002/hep.31597
✅Plasma exchange

#ILC2022 @EASLedu @EASLnews

Summary #ILC2022 @EASLedu #LiverTwitter