Thread by @HadidiSamer

#mmsm Hematologica published 3 articles for sub-group analysis for Isatuximab recently:
1-IKEMA pts with renal failure-Full article
2- ICARIA-MM elderly pt-letter to editor
3-IKEMA+ICARIA-MM: 1q-letter to editor
🛑All used 1-2 medical writers
Was this all the story ? 🧵

Same medical writers helped in a review of key subgroup analysis of ICARIA-MM 👇

Also in doing another subgroup analysis in high risk cytogenetics

You think we are done: NO

ICARIA-MM subgroup analysis 👇

Expert review article with the help of medical writer 👇

Wait there is more , all good journals ICARIA-MM in renal impairment (some recurrent theme)

More and more 👇

ICARIA-MM sub group in East Asian

A letter with sub group analysis

Now more IKEMA subgroup analysis publications 👇in elderly

According to lines of therapy

Asian pts

Now you may ask yourself we the #MedOnc #MedTwiter #mmsm community should care?
🛑Too many subgroup analysis for one or combined studies being published too many times (and presented in conferences even more and repeatedly), I would argue this is a form of drug advertisement

We all want to see the results of trials , even the ones that do have some issues in design, etc. it is too much work by everybody etc, but this number of subgroup analysis for a single drug is not helping me to care for our patients and is bad inflation in publications

Actually this is harmful in other ways:

Look at the journals this was accepted in

Many are of good/excellent quality

Independent investigators submit to many of those journals

What happens?

Desk rejection (a lot of time,no reason)

Many don’t have $ to publish

In academia/clinical research , previously , the article get published fully with all the info and subgroup analysis , we are done. It may get updated once or twice in life time.

Nowadays, we will have updated sub-group analysis for endless things for the same study published and presented too many times reducing chances of others with no good addition to what we already know

Again, I believe we should do better in academia. I will be publishing on this aspects if editors allow my work to be reviewed and reviewers review it without getting it personal
I mean no persons, it is a culture
If we don’t change now, things will get only worse
Sorry long 🧵