Kenar Jhaveri Profile picture
Jul 23 11 tweets 5 min read
Tweetorial: AA amyloidosis and Cancer - New article of analysis in the literature by our #glomerular center visiting faculty @Joyita_4 along with @MSK_Neph faculty @DrOscarLahoud academic.oup.com/ndt/advance-ar… @NDTsocial
2. AA amyloidosis has been classically been associated with -- autoimmune diseases, chronic fevers, infections but AA amyloidosis can develop in a
localized or systemic form in patients with malignant neoplastic disorders
3. We performed a descriptive literature analysis and review of AA amyloidosis with cancer and its treatment.
76 case reports and 3 case/autopsy series with adequate information were included; 2 case reports were excluded due to lack of information on the subtype of amyloidosis.
4. What did we find? Among solid tumors, renal cell carcinoma (RCC) appears to be responsible for one-quarter to half of all cancers associated with amyloidosis.
5. Among other solid cancers, various clinical presentation and pathological types of lung cancer and basal cell carcinoma skin were reported with AA amyloidosis more often than isolated case reports on other cancers with AA amyloidosis.
6.Symptoms from kidney involvement rather than from the tumor per se were the presenting manifestations in cases of RCC associated with AA amyloidosis.
7. What about heme cancers? Clonal B cell/plasma cell dyscrasias such as monoclonal gammopathy and lymphoma were noted to be associated with AA amyloidosis.
8.AA amyloidosis was reported in a small number of cases treated with immune checkpoint inhibitors such as pembrolizumab and nivolumab. @renalmyeloma @MegSise @ShrutiGkidney @onconeph
9. Mechanism of AA amyloidosis with cancer
10. The mainstay of treatment consists of therapy directed against the underlying malignancy or careful withdrawal of the offending agent.
11. Check out the full paper @NDTsocial @HofstraKidney @threadreaderapp #unroll

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More from @kdjhaveri

Jul 20
Tweetorial on a new specialized fellowship in @HofstraKidney northwell.edu/news/the-lates… @jmolinet @SIbrahimMD @sfishbane @purvasharma821 @renalmyeloma
1. Applications due for July 2023 start date- interested Nephrology fellows DM me( till website is ready)
2. Glomerular diseases are rare conditions that do require special expertise and expert centers to treat patients. The @NorthwellHealth GN center run by @purvasharma and @kdjhaveri along with expert pathologists @vbijol @Yihe28745445 will help train the next generations fellows
3. #Onconephrology is a field that deals with cancer and the kidney and is very closely linked with glomerular disease and experts in @HofstraKidney will train the fellow in all aspects of this field @renalmyeloma @kdjhaveri @nupuruppal @VBijol @Yihe28745445 @onconephsociety
Read 6 tweets
Jan 24
1) #Onconephrology @onconephsociety membership Tweetorial- Join membership--how to become a member! ason-online.org/become-a-member
2)If you are interested in becoming a member of a ASON please go to ason-online.org/become-a-member and fill out the form.
3) We just need an example of scholarly activity in the prior 3 years (any manuscript, abstract, presentation related to oncology/onconephrology). We have tried to keep the requirements to a minimum, in order to encourage trainees to join as well.
Read 8 tweets
Jan 22
1) Tweet summary of the review on electrolyte disorders associated with Immunotherapy @CJASN @bdubNephro @nupuruppal @NephroMD cjasn.asnjournals.org/content/early/…
2) Immunotherapy 101 for the Nephrologists- what do Immune checkpoint inhibitors and CAR-T therapy do? @onconephsociety @ASCO
3) Hyponatremia- most common electrolyte abnormality noted with ICI therapy based on several studies, and in real life data pubmed.ncbi.nlm.nih.gov/34556301/ @Kidney_Int @renalmyeloma
Read 15 tweets
Sep 20, 2021
1)Tweetorial: Immune check point inhibitor related electrolyte disorders short letter @Kidney_Int kidney-international.org/article/S0085-… @renalmyeloma and Vipul Sakhiya - the FDA adverse reporting system.
2) Electrolytes were first mentioned @MayoClinicNeph as most common being hypocalcemia pubmed.ncbi.nlm.nih.gov/29762725/
3)Hyponatremia and other disorders were summarized in a single center study @BWHKidney @BetterCallSeeth @MegSise pubmed.ncbi.nlm.nih.gov/33374011/
Read 10 tweets
Sep 10, 2021
1. Green tea- One basic science study I found that showed some benefit in rats with cisplatin pubmed.ncbi.nlm.nih.gov/19647078/- authors postulate that green team increased the activities of the enzymes of carbohydrate metabolism, brush border membrane, oxidative stress.
2) another basic science study in rats showed the similar finding ncbi.nlm.nih.gov/pmc/articles/P…
Read 10 tweets
Aug 4, 2021
Consult Rounds Tweetorial: 1) A 60 y old female- no PMH- arrives for Fever of Unknown origin- COVID test X3 neg, no source found- blood clx, urine clx, all neg scans. - Rheum workup neg. Renal function crt 0.9-1.2mg/dl and urinalysis bland with no WBC and no RBCS, or casts
2) Infectious disease says- less likely culprit is infection- get a Tagged WBC scan.. WBC scan lights up only in the kidneys bilaterally... Renal consult called!!
3)What is your ddx for a positive WBC scan in the kidneys?
Read 14 tweets

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