Thread by @kdjhaveri

Tweetorial: AA amyloidosis and Cancer - New article of analysis in the literature by our #glomerular center visiting faculty @Joyita_4 along with @MSK_Neph faculty @DrOscarLahoud academic.oup.com/ndt/advance-ar… @NDTsocial

2. AA amyloidosis has been classically been associated with -- autoimmune diseases, chronic fevers, infections but AA amyloidosis can develop in a
localized or systemic form in patients with malignant neoplastic disorders

3. We performed a descriptive literature analysis and review of AA amyloidosis with cancer and its treatment.
76 case reports and 3 case/autopsy series with adequate information were included; 2 case reports were excluded due to lack of information on the subtype of amyloidosis.

4. What did we find? Among solid tumors, renal cell carcinoma (RCC) appears to be responsible for one-quarter to half of all cancers associated with amyloidosis.

5. Among other solid cancers, various clinical presentation and pathological types of lung cancer and basal cell carcinoma skin were reported with AA amyloidosis more often than isolated case reports on other cancers with AA amyloidosis.

6.Symptoms from kidney involvement rather than from the tumor per se were the presenting manifestations in cases of RCC associated with AA amyloidosis.

7. What about heme cancers? Clonal B cell/plasma cell dyscrasias such as monoclonal gammopathy and lymphoma were noted to be associated with AA amyloidosis.

8.AA amyloidosis was reported in a small number of cases treated with immune checkpoint inhibitors such as pembrolizumab and nivolumab. @renalmyeloma @MegSise @ShrutiGkidney @onconeph

9. Mechanism of AA amyloidosis with cancer

10. The mainstay of treatment consists of therapy directed against the underlying malignancy or careful withdrawal of the offending agent.

11. Check out the full paper @NDTsocial @HofstraKidney @threadreaderapp #unroll