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Aug 11 • 8 tweets • 2 min read
In this one, coffee was inversely associated with chronic kideny disease in a dose-dependent manner, particularly in females with the effect being stronger in those with higher SHBG and lower testosterone concentrations.
- Among more than 350,000 participants in the UK Biobank, coffee consumption reduced the risk of CKD regardless of genetic risk.
- The effect was sex-specific, and was modified by testosterone and SHBG.
Only females were found to benefit from coffee drinking, with the effect being more robust in those with higher SHBG and lower testosterone concentrations.
- For males, only a small fraction of heavy habitual coffee drinkers with the highest SHBG presented with a tendency of risk reduction in CKD.
"Thus, we hypothesize, one possible explanation underlying the sex-specific reno-protective effect of coffee may be that daily coffee intake, as an isolated aspect of a person's lifestyle...
"...is insufficient to adequately overcome the CKD susceptibility brought about by the naturally high-testosterone and low-SHBG concentrations in males."
Sex-specific association between coffee consumption and incident chronic kidney disease: a population-based analysis of 359,906 participants from the UK Biobank (open access)

doi.org/10.1097/CM9.00…

#coffee #caffeine #CKD #hormones

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More from @nick_krontiris

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Aug 14
This systematic review and meta-analysis finds that both unilateral and bilateral resistance training may improve athletic performance, but the former may be superior on improving unilateral jumping performance and the latter bilateral strength performance.
- Both unilateral and bilateral resistance training were found to improve athletic performance, with no differences in performance measures.
- Subgroup analysis showed that unilateral resistance training can improve unilateral jumping performance with a large effect, but probably provides no benefit on improving unilateral strength performance in comparison to bilateral exercises.
Read 6 tweets
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Aug 14
This systematic review and meta-analysis suggests that high HbA1c variability in individuals with type 2 diabetes may lead to micro- and macro-vascular complications and related death.
- Individuals with type 2 diabetes among the highest quantile HbA1c of all 3 variability metrics had increased risks of all-cause mortality, cardiovascular events, progression to CKD, amputation, and peripheral neuropathy.
- Those among the highest quantile of at least one HbA1c variability metric hadh increased risks of kidney failure, progression to albuminuria, diabetic foot ulcer, and retinopathy.
Read 4 tweets
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Aug 14
In this one, even though 6 months CrossFit training (2×60 min/week) did not improve measures of well-being in inactive adults with predominantly sitting or standing occupations, it resulted in improved mobility and strength.
- The study recruited individuals with a predominantly standing or sitting occupation that did less than two muscle and/or mobility enhancing training sessions per week prior study participation.
- After 6 months significant effects were found for mobility and strength, but not for measures of well-being.
Read 6 tweets
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Aug 13
This study tried to investigate how self-identified dietary lapses, which are defined broadly as eating that is inconsistent with one or more dietary goals, affect reported dietary intake among individuals undergoing a lifestyle modification intervention. ImageImage
- When controlling for their usual intake, participants consumed more calories and added sugar on days on which they reported dietary lapses.
In comparison to prescribed calorie goals (1200–1800 kcals/day based on starting weight), participants consumed an unadjusted average of 253.85 calories above their prescribed goal on lapse days...
Read 6 tweets
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Aug 13
This one found a high adipose tissue insulin resistance in normotensive individuals at baseline, as assessed by adipo-IR, to be associated (although weakly) with new-onset hypertension. Image
- In this study, the authors investigated the association between three insulin resistance indices (adipo-IR, HOMA-IR, and the Matsuda index) and hypertension in older Japanese individuals.
- In the cross-sectional analysis, all of these insulin resistance indices were statistically significantly associated with blood pressure levels.
Read 10 tweets
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Aug 13
This one suggests that aerobic physical activity durations of 3 hours/week and resistance training exercise ~1–2 times/week may substantively reduce the risk of all-cause mortality, with their combination confering additional mortality risk reduction beyond cardio alone. ImageImage
- Higher aerobic PA duration was found to be robustly associated with lower mortality risk and was optimised at ~3 hours/week, largely independent of age and sex. ImageImage
Across all models, an inverse association of aerobic PA with mortality risk with doses as short as ~1 hour/week were found, with results suggesting little additional mortality risk reduction beyond 3 hours/week.
Read 14 tweets

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