Thread by @gesalbla

And another from my former institution, this as a first author!
We found that higher levels of GFAP, an #astroglial marker, were related to higher glucose metabolism 🧠in early stages of #Alzheimer's, especially when GFAP was measured in blood🩸
link.springer.com/article/10.100…

This suggests that a higher astrocytic reactivity in early stages of Alzheimer's, probably in response to #amyloid accumulation, is related to higher glucose consumption. This may (in part) explain why we see higher levels of glucose metabolism in these early stages.

This relationship between GFAP and glucose metabolism became negative in subjects with tau pathology (A+T+), suggesting a failure to sustain the higher energetic demands required by astrocytes. Notably, this was observed in areas of typical AD hypometabolism seen in later stages.

Many thanks to all participants and co-authors: @Marta_Mila_ @MehrnazShekari @NicholasAshton @xgrg @Raffaele_C1 @CarolinaMingui2 @aida_nb @andrealessa @M_SuarezCalvet @JuandoGispert

@fpmaragall #BarcelonaBeta

#ENDAlz