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Viki Male Profile picture
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Aug 18 • 4 tweets • 3 min read
For those interested in the miscarriage rate among those who became pregnant during the trial of the Pfizer #CovidVaccine….

👉🏻 Vaccine group 7%

👉🏻 Control group 15%

👉🏻 These rates are not significantly different from each other, or from normal

1/
fda.gov/media/152256/d…
These data were published about a year ago, but ppl are talking about it today because Naomi Wolf has looked at the FOI data and claims she has found a miscarriage rate of 44%. Unclear how she has done this but seems to be a combination of… 2/
👉🏻 Accidentally counting everything twice (oops)

👉🏻 Counting some ppl who didn’t have miscarriages (eg. males)

👉🏻 Counting miscarriages among the control group (ie. ppl who did not get vaccinated). 3/3
It’s also worth noting that large studies of #CovidVaccine safety in #pregnancy done in the general population (now more than 280,000 ppl vaccinated in pregnancy) show no increased risk of miscarriage following vaccination. 4/3

drive.google.com/file/d/1_wHIYX…

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More from @VikiLovesFACS

Viki Male Profile picture
Aug 18
85,162 ppl giving birth in 🇨🇦May - Dec ‘21, of whom 43,099 had a #CovidVaccine during #pregnancy.

👉🏻 No increased risk of stillbirth, preterm birth or being born smaller than expected following vaccination.

1/
bmj.com/content/bmj/37…
In fact, the authors found a slight reduction in the risk of stillbirth and very preterm birth among those vaccinated. Although they controlled for known confounders, they didn’t feel confident that this wasn’t due to residual confounding. 2/
However, it is in line with the findings from other large studies which show a reduced risk of stillbirth following vaccination… 3/

nature.com/articles/s4146…
Read 4 tweets
Viki Male Profile picture
Jul 7
New preprint looking at 32,536 ppl giving birth in Melbourne 🇦🇺of whom 17,356 received a #CovidVaccine in #pregnancy

👉🏻 Congenital abnormalities, preterm birth and stillbirth all significantly *lower* in the vaccinated group.

medrxiv.org/content/10.110…
🤓 Section

Though this is in line with what we expect, I was surprised to see such clear results in a single study - albeit a big one. Is there a bias here?

In this cohort the vaccinated are generally healthier and wealthier, but the authors adjust for this. 2/
They also restrict the sample to ppl for whom weeks 20-43 following LMP fall entirely within the study period, to avoid fixed cohort bias. 3/
Read 8 tweets
Viki Male Profile picture
Jun 27
@beverleyturner Morning Bev! We've discussed before how female fertility measures were including in the clinical trials. You can find a summary of the outcomes to November 2020 here... 1/

nature.com/articles/s4157…
@beverleyturner And updates on pregnancy outcomes in the Pfizer and AZ trial participants, to August 2021, here... 2/

fda.gov/media/152256/d…

thelancet.com/journals/lance…
@beverleyturner And of course we now also have very extensive data on female fertility following COVID-19 vaccination from the general rollout, with no sign of any harm to fertility in either IVF patients or those trying to conceive through intercourse. 3/
Read 10 tweets
Viki Male Profile picture
Jun 16
@SwaledaleMutton @AGreenroyd1958 @Amber84280581 @NathanaelYoung @somethingsummit @DavidTYork Hi Andrew! I can see why that would worry you, but some key context is missing. These weren’t people who became pregnant accidentally during the trials (though we do have that data too) but rather reports during the general rollout, up to the end of Feb 2021…
@SwaledaleMutton @AGreenroyd1958 @Amber84280581 @NathanaelYoung @somethingsummit @DavidTYork … At that point, around 48,000 people had been vaccinated in pregnancy. Most didn’t make any report because nothing worth reporting happened. You are looking only at the people who *did* make a report, who are naturally enriched for those who experienced a bad outcome…
@SwaledaleMutton @AGreenroyd1958 @Amber84280581 @NathanaelYoung @somethingsummit @DavidTYork (Sources for those numbers…)
Read 6 tweets
Viki Male Profile picture
May 22
@JoelCraig1 The meta analysis we’re talking about included 23 studies and 117,552 people vaccinated in pregnancy. So if you are looking for evidence, that’s a good place to start.

Link again since sounds like you haven’t looked at it yet… 1/

nature.com/articles/s4146…
@JoelCraig1 Some studies didn’t meet the strict predefined inclusion criteria for SR/MA. So you can find more in my own review, published in @NatRevImmunol in March. At the time we had studies on 185,309 ppl vaccinated in pregnancy with no problems appearing. 2/

nature.com/articles/s4157…
@JoelCraig1 @NatRevImmunol But of course more has been done since March! @UKHSA has updated their data and there’s been a new study published by Rudermann. So the evidence base now stands at 239,760 ppl vaccinated in pregnancy, in formal studies, with no problem appearing. 3/ Image
Read 5 tweets
Viki Male Profile picture
May 5
@BerryTartlet @DrLoupis Yes, this is quite an old document. A timeline of UK policy on this might help you.

8 - 31 Dec 2020. Vaccines approved, but using the same exclusions as the trials - no-one who is or could be pregnant. That’s the document you’re looking at there. 1/
@BerryTartlet @DrLoupis Also worth noting that even at that point, there’s nothing saying it’s not safe, only pointing out that we don’t have any evidence yet. 2/
@BerryTartlet @DrLoupis 31 Dec 2020 to 18 April 2021. No requirement to prove you are not pregnant in order to be vaccinated, and vaccines offered to those at particularly high risk due to their profession or medical history. 3/
Read 10 tweets

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