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Lazarus Long Profile picture
@LazarusLong13
Aug 18, 2022 • 6 tweets • 3 min read • Read on X
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Oral and anal swabs could be useful for detecting monkeypox before lesions appear.

If oral and anal swabs are positive? You know they come with airborne aerosols. But this thread is about another study.
Which you might recognize from these graphs showing positive upper respiratory tract swabs.

sciencedirect.com/science/articl… Image
"The infection control implications of upper respiratory tract viral shedding should be considered in future outbreaks."

That means they think #MonkeypoxIsAirborne.

Period. Image
3 weeks breathing out Monkeypox. And more, because they didn't start measuring until lesions appeared.

As my quote tweet in the first tweet said ... Oral swabs were positive BEFORE lesions appeared. Image
Here's the study Ms. Bransell was reviewing.

eurosurveillance.org/content/table/…

You'll notice that NO MATTER THE SYMPTOMS, the oropharyngeal swabs were positive. Image
BTW, If you have Monkeypox and get any symptoms again?

You are contagious again. Image

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More from @LazarusLong13

Lazarus Long Profile picture
Jul 27
Repeated infections.

A thread of why it's a bad idea. Image
Let's start with the newest.

The more hits your immune system takes, the more it primes you for "increasingly profound and protracted #neuroinflammation"

And "multiple inflammatory challenges can add up to be greater than the sum of their parts."

That's not just SARS2.

All disease-causing pathogens like bacteria, viruses, fungi, or parasites. 1st 3 are generally airborne.

Not discussed by their study, but alcohol, heat, processed food, alcohol, smoking - all hit your immune system.

And all have hammered LongHaulers.
Read 9 tweets
Lazarus Long Profile picture
Jul 24
Hypothesis: reducing the inoculum you are exposed to will result in a less severe infection.

Follow-up Hypothesis: wearing a respirator will result in less severity than cleaning the air with a HEPA.

Been thinking on this for a long while. Here are the underpinnings.
🧵
On the first, this is a pretty common theory. Here's a good quick overview of the idea 👇.

Greater the inoculum, the worse the outcome.

A dose-response relationship between viral load and outcome, to use the more scientific parlance.

thelancet.com/journals/lanin…

The influence of the inoculum on disease severity is more challenging to study in humans, given that some viruses only cause mild clinical manifestations in immunocompetent human hosts. Viruses that cause severe disease symptoms are too dangerous to study experimentally in humans, and disease severity is more challenging to measure than is infection itself. However, in one controlled experiment with respiratory syncytial virus, five of the seven human participants who were successfully infected with undiluted, higher dose virus inoculum (105 plaque-forming units) administered intranasally, ...
Given the severity of illness associated with SARS-CoV-2 infection, human challenge studies are controversial.31 However, in an animal model of SARS-CoV-2 infection, Syrian hamsters were successfully infected with two different doses of SARS-CoV-2, intranasally and intraocularly, and the higher dose was associated with greater weight loss and more severe lung abnormalities on chest imaging.32 In another experiment, when a surgical mask partition was placed between the cages of infected and uninfected Syrian hamsters, only six (25%) of 24 hamsters protected by the surgical mask partition wer...
Here's an epi example of two groups of soldiers spatially separated, but very similar in make-up.

Group after masking and social distancing
13 (15%) of 88 asymptomatic.

Group before masking
102 (47%) of the 215 soldiers who tested positive were symptomatic. Some epidemiological data1, 2, 3, 4, 5, 37 suggestive of the viral inoculum effect with SARS-CoV-2 are also worthy of notice. A natural experiment of sorts occurred in the Swiss Alps between March 25, 2020, and April 14, 2020, in two spatially separated homogenous cohorts of soldiers of similar age (median age 21) and without substantial comorbidities.4 After a COVID-19 outbreak occurred in one of the cohorts, physical distancing and surgical mask-wearing was implemented in both cohorts. An outbreak of COVID-19 in the previously unaffected cohort occurred after the implementation of th...
Read 16 tweets
Lazarus Long Profile picture
Jul 22
🔥 Wildfire season, folks! 🔥

Got a smoky or smokey house from a fire or a BLT sandwich gone wrong?

TLDR;
Make a #CorsiRosenthalBox with activated carbon filters

AND CLEAN SURFACES:
By vacuuming, dusting; then wiping and mopping with a commercial, non-bleach solution. Pic of smoke and fire - hopefully not headed your way.
Huge caveat. The carbon filters will fill up quickly with particulate matter.

While the smoke is ongoing? Regular filters.

After the smoke is over, while cleaning up? The activated carbon filters (ACF).

Someone is working on a variation of the CR Box w/ 3 regular panels,
1 ACF panel. Numbers are still being run. No ETA, so I am going forward with this thread, as is.

⚠️ACFs are also great for paint fumes.⚠️

BTW, this thread will get a fair amount of useful clarifications, so check the end of the thread, in a couple of days.
Read 21 tweets
Lazarus Long Profile picture
Jul 22
A new strategy.

I used this new study, that points to C0vid co-infection with StaphA, worsening StaphA, to write the HICPAC.

The patient safety pages do not recommend N95s.

This allows me to avoid the quarrel of StaphA OR C0vid being airborne.

Image
Image
And allows me to use their words on N95s being best for C0vid against them.

Soft-copy email below.

hicpac @ - just join these together.

This strategy can be used on every safety page for every disease.

cdc.gov
docs.google.com/document/d/12y…


Image
Image
Image
- SARS-COV-2
hastens
worsens
X

Find the X CDC safety page. Confirm no N95s recommended. They never are.

And you are off to the races.

Some will think, "this is just some weird internet trick."

This is just us using their system against them.Scholar.google.com
Read 4 tweets
Lazarus Long Profile picture
Jul 19
A NEW Colorado Chicken farm outbreak with 1.34 million.

The one with 5 people confirmed infected, 64 pending, has 1.8 million, 10-14 days of work.

CDC team of 10 has just been dispatched for the 1.8 million.

The farms are about 35 minutes apart (thank you @0bFuSc8!)

Image
Image
Read 5 tweets
Lazarus Long Profile picture
Jul 16
Holy airborne H5N1.

69 symptomatic workers, 5 positive so far?

150 on antivirals?
It's always been airborne.

This means that it is more transmissible to the humans than before.

Not Covid levels. Probably not even original WT level.

But more transmissible to the humans than before.
Homeland Security moved to Level 2.

Read 8 tweets

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