Dr Emma Hodcroft Profile picture
Aug 26 β€’ 8 tweets β€’ 7 min read
Our paper on relabelling the internal clades of the #monkeypox to be non-geographical, & proposing a new lineage naming system within Clade IIb, is now out in @PLOSBiology πŸ™ŒπŸ»
This has been an international effort I'm humbled to be part of.

journals.plos.org/plosbiology/ar…

1/8
Because it seems like there's a lot of misunderstanding around this paper/proposal - our paper does *not* touch on renaming the #monkeypox virus itself.
We focus on switching to more structured, non-stigmatizing & standardized naming within the virus phylogeny.

2/8
Contrary to what many people believe, there are long-standing efforts to name new viruses, & re-label old virus-related terms (like clades/lineages/strains), to avoid potentially stigmatizing & often inaccurate names. But previously, you didn't hear of it in the media! 😁

3/8
Names are powerful, & they matter. Many people still believe the 1918 pandemic flu started in Spain due to the nickname 'Spanish flu' - over 100 years later!

By being more conscientious in our naming, we can give better, more accurate, & more useful names.

4/8
And we scientists are also great at multitasking: while we consider the clade/lineage names in #monkeypox, we can also lobby for equity in vaccines/treatment & raise awareness that MPX has previously not gotten the scientific attention it deserved. It's not either-or!

5/8
It's been an honour to be part of the group working on this, in particular, Andrew Rambaut @borges__vitor @richardneher @Tuliodna @trvrb @CorneliusRoemer @NikitaSitharam @CrystalGigante @christian_happi @IfedayoTiffy @GeraldGmboowa @laktarr001 @sofoniaskt @houzhou

6/8
@EvolveDotZoo @AineToole @AngieHinrichs @MOUGK @EduanWilkinson, and coordination with
@WHO, @acegid & @AfricaCDC & the Africa-based contributors Placide Mbala, Richard Njouom, Emmanuel Nakoune, Anise Happi, Nnaemeka Ndodo, & Oyeronke Ayansola

7/8
These new clades/lineages are only a small step, but I hope one that is helpful in raising awareness & decreasing stigma, as we all continue to work hard to advance our scientific understanding of #monkeypox & advocate for a better & more equitable global #MPX strategy.

8/8

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More from @firefoxx66

Aug 12
πŸ“£CoVariants.org Update!πŸ“£

To help your Friday be fantastic 😎, I'm happy to say that we've updated CoVariants with awesome new graphs that load on-demand, speeding up the browsing experience!

HUGE thanks to @richgoater for implementing! πŸŽ‰πŸ™πŸ»

1/3
With this new addition, graphs now load dynamically as you scroll, speeding up overall loading time & reducing the overhead (especially on older mobile devices πŸ“±).
Check it out on covariants.org/per-country, or the Per Variant or Cases pages!

2/3
As we try to graph more data from more places over longer times, we're always interested in improving our graphs & website!
If you'd like to help, check out the issues on our Github or reach out with an idea - we love contributions! πŸ₯°

3/3

github.com/hodcroftlab/co…
Read 4 tweets
Aug 5
Monkeypox:
- We've had warnings about it for years
- We have a vaccine
- We have antivirals
- We have experience w poxviruses

Pandemic Preparedness is a buzzword right now, but if we don't seem to be prepared to effectively combat #monkeypox... Is that what we want?

1/
I am not implying that combatting #monkeypox is easy - & the current outbreak has plenty new to figure out (cryptic transmission, new presentation & lesion locations, MSM spread, ABOBEC mutations).

But we've had so much opportunity to be better prepared than we seem to be.

2/
Very few viruses arrive with the headlines they do in movies.
But #monkeypox really did send heralds for years before the current outbreaks. πŸ“£ The waning of smallpox vaccines. The signs of ongoing transmission.

So what should we be doing better?

3/
Read 6 tweets
Jul 27
πŸŽ‰CoVariants.org Update!πŸŽ‰

22D (BA.2.75) is now available on CoVariants! It's visible as part of Per Country & Per Variant plots, on the shared mutation page - and of course, has a page of its own!

1/8

#BA275 #centaurus

covariants.org/variants/22D.O…
This is in line with the recent addition of 22D (BA.2.75) as a @nextstrain clade - read more on that below! πŸ‘‡πŸ»

2/8

On the 22D page, you can read about some initial 22D / BA.2.75 work on things like immune-evasion, see a list of defining mutations, a plot of the variant growth, link to Aquaria protein viz, & see a list of other mutations present in the variant.

3/8

covariants.org/variants/22D.O…
Read 8 tweets
Jul 22
πŸ“―CoVariants.org UpdateπŸ“―

As I mentioned yesterday, from today we switch the Per Variants page to 2-week intervals without smoothing & fixed the "New Year bug" - making interpretation clearer & cleaner! πŸŽ‰

covariants.org/per-variant

1/7
HUGE thanks to @MoiraZuber & @ivan_aksamentov for their work on this! πŸ™πŸ»

Previously, Per Country was by 2-weeks (unsmoothed) & Per Variant was 1-week (smoothed) - this made reconciling numbers confusing & unintuitive. The change makes all of that easier!

2/7
As part of this, you'll notice the graphs look a little more jumpy & angular πŸ“. That's what happens when smoothing turns off!
But, it more closely represents the real data - I think this is a worthy trade-off!

3/7
Read 7 tweets
Jul 21
So far, #monkeypox seems generally mild (if sometimes very painful & physically scarring) - but is that enough not to worry?
I still think we need to consider our response carefully.

If it continues to be hard to contain, what are the medical *and* social risks?

1/14
At the moment, the #monkeypox outbreak impacts some parts of our world & society more than others - this is always dangerous as it makes dismissal easier. It's not threatening 'most of us' - at least not right now.



2/14
But if #monkeypox becomes widely endemic in MSM (men who have sex with men) populations, what might this mean?

1st, wider spread == more chance of spillover into other groups. Vulnerable, elderly, children - where outcomes may be different/worse.

3/14
Read 15 tweets
Jul 21
πŸ—’οΈCoVariants.org announcementπŸ—’οΈ
Currently on the Per Variants page, we use 1-week counts + smoothing. We're hoping to move away from this in the near future, & change to 2-week unsmoothed (same as we do for Per Country) for consistency.

1/2

covariants.org/per-variant
If you regularly use the Per Variant data & are concerned about any impacts from this change, please feel free to reach out on our Github Discussions page!

2/2

github.com/hodcroftlab/co…
As an update, this'll probably get merged in tomorrow morning (CET), so please do shout soon! File format will *not* change, but the interpretation will change slightly - and be closer to the raw numbers (thanks to getting rid of smoothing).
Read 5 tweets

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