Nikki Teran Profile picture
Sep 8 14 tweets 4 min read
If any conference was going to do it right it would be #CHSIAQ2022

I’m super appreciative that I can safely be in person and even sip my coffee!

That lamp kills germs that float above our heads. The building has MERV15 filters. Everyone is masked. Everyone tested this morning. Image
And these little lamps shine low-wavelength light that is safe for people but can kill germs.

Way to go @JHSPH_CHS Image
Fun facts from the speakers:

There’s a linear relationship between co2 levels and cognitive function. More co2 makes it harder to think. The same is true for particulate matter.

Clean air is good for students and employees beyond protecting against infectious disease.
Current building indoor air quality standards are design based, not performance based.

That’s like your landlord ensuring your house has a heater, but not that it still works, much less that it pumps out more warm air when it’s colder outside.
One of congress’s plans for helping to improve IAQ via improved ventilation and filtration would be done through tax credits.

R’s aren’t much in to government spending but they are against taxes, making tax credits a more palatable option.
It’s important to not overfit the improvements to our built environment to COVID.

Children are less vulnerable in this pandemic but that doesn’t mean they will be for the next one. Image
It’d be cool if buildings had an obvious rating for their indoor environment quality like restaurants have letter grades from the health inspector.

Live measurements would be even ideal, but right now we’ve got squat. ImageImage
CFM vs CADR: Cubic feet per minute is total air moved through a device. Clean air deliver rate measures how much clean air comes out of a system.

If all of the air going through the system goes through a filter, CFM=CADR. If air can go around, CFM>CADR.
If you know the size of the room (including ceiling height!) you can calculate the air changes per hour (ACH).

The number of ACH you should have really depends on how many people are in the room. Image
I missed taking a photo of the slide, but the recommended number of ACH has gone down from 30 to 5 due to energy use concerns, but more would be better for preventing indoor disease transmission.
Using something like upper room germicidal UV you can get the equivalent of 100s or even 1000s of ACH equivalents.

But obviously you need to get some good air mixing.

Gotta use those ceiling fans!
“Don’t buy wine in clear bottles… even the fluorescent lights in grocery stores will denature it to some measurable level.”
New speaker is pushing back against the idea of 1000s of ACHe because air doesn’t typically mix that fast. He’s skeptical of anything over ~12 ACHe.

Zhu et al looked at how long exhaled air hung around in a space like a bus. How crowded the bus is makes a big difference. Image
More ACH numbers: supposedly, given how contagious BA.5 is, you’d need 31.8 ACH to (completely?) prevent transmission.

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More from @DrNikkiTeran

Mar 14
The White House asked for $65B for pandemic preparedness.

The Senate released a draft bill that includes less than $2B.

progress.institute/preventing-pan…
Don’t get me wrong, there are great parts and I want it to pass.

It’ll give HHS a lot of authority to expedite EUA.
It will help scientists safely respond to pandemics.

(And potentially could prevent a man-made pandemic.)
Read 7 tweets
Jan 26
Yes, please. I want all the information! I want the FDA to be more liberal with EUA and provide comprehensive information directly to the public.
It would be nice if someone could do something about the sale of fake masks. Early in the pandemic I saw some kn95’s from Amazon that, instead of perforations, clearly had holes in them…
This sounds good in theory. I’m hoping it doesn’t accidentally prevent manufacturers from being able to produce devices because it’s difficult/costly to implement. Also, IDK enough about supply chains, but, even if you have redundant suppliers, couldn’t they share a supplier?
Read 5 tweets
Jan 26
The Prepare for and respond to existing Viruses, Emerging New Threats, and Pandemics Act (PREVENT Pandemics Act) is even better than the name*.

If you want some highlights, hop on and join my read along.

Let's dive in.
[thread]

*and I thoroughly enjoy the name
I'm curious what "full-scale exercises" actually means. Given how well we're doing at distributing things from the SNS right now, two years in to the pandemic, any practice would be useful. It'd be amazing if this could include things like a practice OWS.
There's a bunch of clarification/instruction that ASPR is in charge of things. The PR in ASPR stands for "preparedness and response" so it's great for them to know exactly what they're in charge of.
Read 25 tweets
Feb 4, 2021
Nonsense-mediated decay (NMD) is highly stable across individuals and tissues.
Therefore you can predict whether a nonsense mutation will be degraded and have some confidence that’s what’s actually happening in any person and in any tissue.
biorxiv.org/content/10.110…
Nonsense mutations created a “stop” before the end of the gene. Cells can’t get rid of the bad DNA, but they can get rid of the bad RNA so it doesn’t make a bunch of bad protein nubbins. Nonsense-mediated decay degrades the RNA that have these protein truncating variants (PTVs).
It’s good but not perfect: sometimes the mutations “escape”. Mutations that escape usually follow some “rules”: they’re near the end of the gene (in the last exon or 50-55 nucleotides before the last exon, aka the 50nt rule), near the beginning of the gene, or in a long exon.
Read 14 tweets

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