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Nikki Teran Profile picture
Nikki Teran
@DrNikkiTeran
Yes, I would love to explain that bio thing to you.
Oct 30, 2023 • 5 tweets • 3 min read
Will releasing the weights of large language models grant widespread access to pandemic agents?

Turns out, yes, probably.

1/5 Image The MIT group used virology-specific papers to fine-tune two open-source LLMs.

One model came pre-prepped with its safeguards already trained out, making it “spicy” 🌶️

The base model Llama-2-70B cost ~$5M to train, but the virology-specific fine-tuning only cost about $20.

2/5
Sep 8, 2022 • 14 tweets • 4 min read
If any conference was going to do it right it would be #CHSIAQ2022

I’m super appreciative that I can safely be in person and even sip my coffee!

That lamp kills germs that float above our heads. The building has MERV15 filters. Everyone is masked. Everyone tested this morning. Image And these little lamps shine low-wavelength light that is safe for people but can kill germs.

Way to go @JHSPH_CHS Image
Mar 14, 2022 • 7 tweets • 4 min read
The White House asked for $65B for pandemic preparedness.

The Senate released a draft bill that includes less than $2B.

progress.institute/preventing-pan… Don’t get me wrong, there are great parts and I want it to pass.

It’ll give HHS a lot of authority to expedite EUA.
Jan 26, 2022 • 5 tweets • 2 min read
Yes, please. I want all the information! I want the FDA to be more liberal with EUA and provide comprehensive information directly to the public. It would be nice if someone could do something about the sale of fake masks. Early in the pandemic I saw some kn95’s from Amazon that, instead of perforations, clearly had holes in them…
Jan 26, 2022 • 25 tweets • 10 min read
The Prepare for and respond to existing Viruses, Emerging New Threats, and Pandemics Act (PREVENT Pandemics Act) is even better than the name*.

If you want some highlights, hop on and join my read along.

Let's dive in.
[thread]

*and I thoroughly enjoy the name I'm curious what "full-scale exercises" actually means. Given how well we're doing at distributing things from the SNS right now, two years in to the pandemic, any practice would be useful. It'd be amazing if this could include things like a practice OWS.
Feb 4, 2021 • 14 tweets • 6 min read
Nonsense-mediated decay (NMD) is highly stable across individuals and tissues.
Therefore you can predict whether a nonsense mutation will be degraded and have some confidence that’s what’s actually happening in any person and in any tissue.
biorxiv.org/content/10.110… Nonsense mutations created a “stop” before the end of the gene. Cells can’t get rid of the bad DNA, but they can get rid of the bad RNA so it doesn’t make a bunch of bad protein nubbins. Nonsense-mediated decay degrades the RNA that have these protein truncating variants (PTVs).