Thread by @dbdugger

#LongCovid #Truvada #PorscheVsPinto #DoubleNukeIt
@BradyDale311 was kind enough to send over a journal article that just hit the news today and it appears to offer a great deal of promise. aidsmap.com/news/oct-2022/…

@BradyDale311 As someone intimately familiar with the concepts of reservoir seeding, estimated date of seroconversion, and one who has observed haunting parallels between the pathophysiology of chronic HIV and SARS-Cov-2 infections, I knew repurposing was necessary and have written about it.

@BradyDale311 Molecular docking studies have proven that a number of first line HIV antivirals proved the ability to do so. While there have been studies investigating the use of Truvada as PreP and treatment, the results have been mixed.

@BradyDale311 One would expect the results to be mixed when we have no viral load test to confirm a drop in log copies for those instances where it is used in treatment. How can you say it is not effective, lmao.

@BradyDale311 I had suggested in one Tweet that it made sense to look at the rates of SARS-Cov-2 infection among a population that is made up of varying degrees of immune competence and that is exactly what this study did.

@BradyDale311 For those individuals on a Tenofovir Disoproxil Fumarate/Emtricitabine regimen, Stribild, only 28 individuals contracted SARS-Cov-2. Only 5 individuals who were on the same regimen required hospitalization.

@BradyDale311 For those on a Tenofovir Alafenamide Fumarate/ Emtricitabine regimen, which could either be Genvoya or Biktarvy, 621 individuals contracted SARS-Cov-2 and 156 were hospitalized.

@BradyDale311 Why the difference in TDF vs. TAF? Less TAF is required to exert the same degree of virologic control and is less toxic to the body.

@BradyDale311 So, now we can start to investigate further. Is Elvitegravir or Bictegravir efficacious? What would be the results if cobicistat was added as a separate pill.

@BradyDale311 My hypothesis as to why we haven't seen favorable results with PreP in the past is due to the possibility of Nasal Associated Lymphoid Tissue concentrations not being great enough as that of the Gut Associated Lymphoid Tissues.

@BradyDale311 While the length of suppression is not mentioned, I do know that it takes 6 months of having 200 copies of HIV in your semen before deemed unable to transmit.

@BradyDale311 If you are an individual suffering from a chronic SARS-Cov-2 infection and would like for me to discuss possible antiviral strategies based upon these findings, please reach out.