1/x 🧵Thank you to @bmj_latest for an excellent article doi.org/10.1136/bmj.o2… by @Garethiacobucci "Evusheld: Government is urged to expedite covid antibody treatment for vulnerable patients". It highlights ongoing clinical pressure to protect the #immunocompromised. Pls RT Image
2/x What's the issue......"With covid-19 cases rising 📈 and winter approaching, immunocompromised patients are frustrated at the government’s 🏦 inaction on rolling out the preventive drug" 💉 Image
3/x "The UK government has been urged to re-examine its decision not to purchase a new covid-19 antibody drug for clinically extremely vulnerable people, amid warnings that these patients face renewed risk from the disease this winter."😢 Image
4/x "Evusheld was approved for use in the UK in March 2022 by the Medicines and Regularly Healthcare Products Agency after trial results showed that it reduced the risk of developing symptomatic covid-19 by 77%, with protection lasting at least six months after a single dose." Image
5/x "Evusheld is submitted for approval by the National Institute of Health and Care Excellence. But, because this process is not due to conclude until well into 2023, clinicians & patients have warned that people who could potentially benefit will miss out this winter." Image
6/x What's my take? Well, there are inconsistency between the government’s policy on covid vaccines and its approach to antibody treatments. The window 🪟 for protecting very vulnerable patents this winter was rapidly closing...
7/x Why does this matter? There are half a million immunocompromised people in the UK. Many are still shielding, still in isolation, still unable to work, see friends or hug loved ones. They are #forgotten500k, unheard and calling on us to notice.
8/x Thanks to patients, clinicians @AlexRichter3 @ProfBMT, the clinical community has also sprung into action. Patients, 125 clinicians from 17 medical specialities & 4 nations are united in asking for action and potentially the missing decision maker.
9/x Thanks to @libdemdaisy, there is now a parliamentary debate on 12th of October at 11am. whatson.parliament.uk/event/cal39847. We hear MPs are being swamped by emails from patients and their doctors asking for action on to protect the immunocompromised
10/x And in a unusual twist, patient groups and their 19 charities are now asking relatives, grandchildren and grandparents to sit in parliament square on their behalf. The aim is to get DHSC civil servants to notice them and give them protection. I've not seen patient power like Image
11/x this before. UK patients wish to have the same protection as available in France, US and 32 other countries. There are half a million immunocompromised people in the UK. Many are still shielding, still in isolation, still unable to work, see friends or hug loved ones 😢 Image
12/x They #forgotten500k unheard & calling on us to notice. So many people left behind. From the comments 👇- patients/clinicians are grateful for people like @Garethiacobucci for going the extra mile to share the story & plight for protection +🤞 for a good outcome before xmas. Image

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More from @drlennardlee

May 16
1/x *** New Research ***. 😀What can be done to protect immunocompromised patients? New press release from @AstraZeneca. , and it's about a therapy called Sipavibart, the successor to Evusheld. astrazeneca.com/media-centre/p…
Image
2/x. What is the background? Some individuals in our community are more prone to infections, they are called immunocomromised. There are ~ 500,000-1.5M with these conditions. When they get infections, they can fight it less well. 🙄 And the pandemic hit, this was a problem.
3/x It includes renal transplant patients, primary immunodeficiencies, those with cancer & blood cancers, kidney disease, and those with primary immunodeficiencies. It's a fair number. Most doctors want to protect these patients from infectious diseases by what ever means 😇
Read 11 tweets
Jul 25, 2023
1/x 🧵 ***NEW RESEARCH *** How has #COVID-19 disease evolved in people living with #cancer and who remains at risk? Find out more in our latest publication from @UKCORONACANCER: https://t.co/P9NdBtbCRWnature.com/articles/s4159…
Image
2/x It is relevant as healthcare systems develop strategies for living with SARS-CoV-2 as an endemic disease and informing individual discussions between cancer patients and their oncologists. And to ensure that no one is left behind or forgotten. Image
3/x What was done? They analysed COVID-19 infections in the 🏴󠁧󠁢󠁥󠁮󠁧󠁿 population, assessing rates of COVID-19 related hospitalisation, intensive care admission and mortality. It ran Winter 20-Summer 22 Image
Read 11 tweets
May 21, 2023
1/x #Cancercapacitychallenge @FinancialTimes V. Relevant #cancer. It's interesting with good & also worrying stories.... 😀☹️ From UK professionals @RCRradiologists @BOPACommittee @ACPUK @UKONSmember ft.com/content/b22e21… 👇RT if agree ImageImageImage
2/x What's the issue ? The UK delivers successful cancer care. Year on year, people live longer and better lives. gov.uk/government/new…. 10% improved survival in 15 years. That is by achieved early diagnosis, having better treatment the best cancer staff, research. 😀🏆🇬🇧✊ ImageImage
3/x but.... there's a flipside. Our Cancer leadership quote "Demand for cancer treatment is increasing by approximately 6-8% every year" and "They are being asked to deliver more treatment with the same staffing numbers"
Read 12 tweets
Jan 22, 2023
1/x 🧵This Friday at 10:30am, we're excited to announce the reboot of the #forgotten500K campaign with an update from the podcasts hosted by @claremenglish, @MarkOak04974342, @NikolaBrigden. Here's the message for 2023 in advance. RT. 👇
2/x "The #forgotten500K are a group of immunocompromised patients who have not been prioritized during the pandemic and are experiencing higher ongoing levels of risk. The group started off as individuals asking for help while still in isolation during the pandemic.
3/x They were speaking as individuals trying their best to be heard virtually, as they were not able to leave their homes and re-enter normal life like everyone else. However, the #forgotten500K patient campaign brought them together, providing support and one voice. amazing
Read 18 tweets
Oct 29, 2022
1/x Several months ago, @katebingham2 drove the UK pandemic response. She is incredible 🦸‍♀️- thanks for your insight. But then she finished and something extraordinary happened. The Winter plan to protect the #immunocompromised was quietly dropped....😫 Why does it matter? 🤷🤷‍♂️🤷‍♀️
2/x Because it had widespread clinical & academic backing for our 2022 Winter plan. Cohorts were identified & large teams of clinicians worked around the clock to work out which of #immunocompromised who don't have high levels of protection from vaccination could be protected 👩‍⚕️ Image
3/x This would have put us in line with 32 countries who were protected their #immunocompromised during the Winter months when COVID cases rise. If you don't respond to vaccines 💉, then your risk of hospitalisation, ITU admission & not recovering from COVID is 📈 Image
Read 11 tweets
Oct 26, 2022
1/x 🧵 ***NEW RESEARCH 👨‍🔬 *** About #immunocompromised #forgotten500k #cancer. It's a BIG paper, analysing the global data 🗺️. Answers the question- how big is the issue of absent immune responses following covid vaccines. @BrJCancer by @michaeltilby nature.com/articles/s4141… 💛💚
2/x Why did they do it? Because 1⃣ cancer patients are at high risk from covid 📈 2⃣ Many don't get an immune response to vaccines 💉 3⃣ They wanted to find the scale of the problem 💥. So they decided to go global! 🌐
3/x. The team searched 3065 papers published from the start of vaccination to March 2022. They looked at third dose boosters 💉. They looked across all cancer types. They found 15 studies encompassing 1205 patients🧑‍🤝‍🧑. The largest global review 🌍
Read 11 tweets

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