Dr Lennard Lee (Oxford University) Profile picture
Oct 18, 2022 โ€ข 13 tweets โ€ข 8 min read โ€ข Read on X
1/x ๐Ÿงต ***NEW RESEARCH *** from @EdinburghUni. The paper is relevant for the #immunocompromised and #evusheld and #forgotten500k. It really acts as a WAKE UP & ACT call. It a good paper. thelancet.com/journals/lanceโ€ฆ Image
2/x What's the background? The pandemic continues. ๐Ÿ‘พSome people are at excess risk and can't hug loved ones, see family or enter normal life ๐Ÿ˜ข. We all believe they are the #immunocompromised, but what does the data show? ๐Ÿ’ป Image
3/x This data looked at 16โ€ˆ208โ€ˆ600 vaccined individuals across England๐Ÿด๓ ง๓ ข๓ ฅ๓ ฎ๓ ง๓ ฟ, Scotland๐Ÿด๓ ง๓ ข๓ ณ๓ ฃ๓ ด๓ ฟ, Ireland ๐Ÿ‡ฎ๐Ÿ‡ช and Wales ๐Ÿด๓ ง๓ ข๓ ท๓ ฌ๓ ณ๓ ฟ. i.e. EVERYONE. From Dec 8, 2020, and Feb 28, 2022, so it includes the OMICRON ERA, so relevant. Risk was very carefully defined.
4/x What did they find? ๐Ÿ‘‡๐Ÿซข. For a few significantly higher risk. nearly 6x for the immunocompromised. Also risk for those with more comorbidies, and this includes those with immunocompromised disease. But if you survive, you are proteted for 9ms... Image
5/x More detail now. Here's the risk table. we call it a forest plot. The red dot represents risk ๐Ÿ”ด. The lines represents uncertainty. Adjusted risk is at the bottom, 0-25x. I've added orange boxes- ๐ŸŸง , for the #immunocompromised. Image
6/x. What do they say? ๐Ÿ‘‡ Image
7/x Anything else they found? If you add in age, particularly above 70, then the risk climbs. Previous risk factors like ethnicity, deprivation, BMI, urban/rural no longer drive risk. #immunocompromised DOES! @SGriffin_Lab Image
8/x Why does this matter? There are half a million immunocompromised people in the UK. Many are still shielding, still in isolation, still unable to work, see friends or hug loved ones. They are #forgotten500k, unheard and calling on us to notice. Image
9/x Prophylactic antibody therapies like #evusheld give back an โ€œimmuneโ€ system to those who are immunocompromised. It is given in a similar way to a vaccine and it prevents infections. Studies from Israel/France/US show it is working well, even against omicron Image
10/x 32 countries are delivering additional levels of protection this winter to protect immunocompromised patients who have not responded to the coronavirus vaccine, using new therapies, not available in the UK- prophylactic antibody therapies. Image
11/x Thanks to patients, clinicians @AlexRichter3 @ProfBMT + myself as champions, the clinical community has also sprung into action. Patients, 125 clinicians from 17 medical specialities & 4 nations are bringing online professional organisations/charities for a call to action.
12/x No one is sure if DHSC will offer protection or consider a pilot to protect #immunocompromised patients with #evusheld this Winter. Budgets might be an issue. However, patient power has seemingly swung into action. They are asking in mass about what they need. @hughesthenews Image
13/x We are yet to know if the data will be actioned, or levers pulled by @DHSCgovuk. Thank you to @EdinburghUni for another amazing hard hitting article putting a microscope to the risk to the population from COVID-19 and #immunocompromised. #Tourdeforce.

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More from @drlennardlee

May 16
1/x *** New Research ***. ๐Ÿ˜€What can be done to protect immunocompromised patients? New press release from @AstraZeneca. , and it's about a therapy called Sipavibart, the successor to Evusheld. astrazeneca.com/media-centre/pโ€ฆ
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2/x. What is the background? Some individuals in our community are more prone to infections, they are called immunocomromised. There are ~ 500,000-1.5M with these conditions. When they get infections, they can fight it less well. ๐Ÿ™„ And the pandemic hit, this was a problem.
3/x It includes renal transplant patients, primary immunodeficiencies, those with cancer & blood cancers, kidney disease, and those with primary immunodeficiencies. It's a fair number. Most doctors want to protect these patients from infectious diseases by what ever means ๐Ÿ˜‡
Read 11 tweets
Jul 25, 2023
1/x ๐Ÿงต ***NEW RESEARCH *** How has #COVID-19 disease evolved in people living with #cancer and who remains at risk? Find out more in our latest publication from @UKCORONACANCER: https://t.co/P9NdBtbCRWnature.com/articles/s4159โ€ฆ
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2/x It is relevant as healthcare systems develop strategies for living with SARS-CoV-2 as an endemic disease and informing individual discussions between cancer patients and their oncologists. And to ensure that no one is left behind or forgotten. Image
3/x What was done? They analysed COVID-19 infections in the ๐Ÿด๓ ง๓ ข๓ ฅ๓ ฎ๓ ง๓ ฟ population, assessing rates of COVID-19 related hospitalisation, intensive care admission and mortality. It ran Winter 20-Summer 22 Image
Read 11 tweets
May 21, 2023
1/x #Cancercapacitychallenge @FinancialTimes V. Relevant #cancer. It's interesting with good & also worrying stories.... ๐Ÿ˜€โ˜น๏ธ From UK professionals @RCRradiologists @BOPACommittee @ACPUK @UKONSmember ft.com/content/b22e21โ€ฆ ๐Ÿ‘‡RT if agree ImageImageImage
2/x What's the issue ? The UK delivers successful cancer care. Year on year, people live longer and better lives. gov.uk/government/newโ€ฆ. 10% improved survival in 15 years. That is by achieved early diagnosis, having better treatment the best cancer staff, research. ๐Ÿ˜€๐Ÿ†๐Ÿ‡ฌ๐Ÿ‡งโœŠ ImageImage
3/x but.... there's a flipside. Our Cancer leadership quote "Demand for cancer treatment is increasing by approximately 6-8% every year" and "They are being asked to deliver more treatment with the same staffing numbers"
Read 12 tweets
Jan 22, 2023
1/x ๐ŸงตThis Friday at 10:30am, we're excited to announce the reboot of the #forgotten500K campaign with an update from the podcasts hosted by @claremenglish, @MarkOak04974342, @NikolaBrigden. Here's the message for 2023 in advance. RT. ๐Ÿ‘‡
2/x "The #forgotten500K are a group of immunocompromised patients who have not been prioritized during the pandemic and are experiencing higher ongoing levels of risk. The group started off as individuals asking for help while still in isolation during the pandemic.
3/x They were speaking as individuals trying their best to be heard virtually, as they were not able to leave their homes and re-enter normal life like everyone else. However, the #forgotten500K patient campaign brought them together, providing support and one voice. amazing
Read 18 tweets
Oct 29, 2022
1/x Several months ago, @katebingham2 drove the UK pandemic response. She is incredible ๐Ÿฆธโ€โ™€๏ธ- thanks for your insight. But then she finished and something extraordinary happened. The Winter plan to protect the #immunocompromised was quietly dropped....๐Ÿ˜ซ Why does it matter? ๐Ÿคท๐Ÿคทโ€โ™‚๏ธ๐Ÿคทโ€โ™€๏ธ
2/x Because it had widespread clinical & academic backing for our 2022 Winter plan. Cohorts were identified & large teams of clinicians worked around the clock to work out which of #immunocompromised who don't have high levels of protection from vaccination could be protected ๐Ÿ‘ฉโ€โš•๏ธ Image
3/x This would have put us in line with 32 countries who were protected their #immunocompromised during the Winter months when COVID cases rise. If you don't respond to vaccines ๐Ÿ’‰, then your risk of hospitalisation, ITU admission & not recovering from COVID is ๐Ÿ“ˆ Image
Read 11 tweets
Oct 26, 2022
1/x ๐Ÿงต ***NEW RESEARCH ๐Ÿ‘จโ€๐Ÿ”ฌ *** About #immunocompromised #forgotten500k #cancer. It's a BIG paper, analysing the global data ๐Ÿ—บ๏ธ. Answers the question- how big is the issue of absent immune responses following covid vaccines. @BrJCancer by @michaeltilby nature.com/articles/s4141โ€ฆ ๐Ÿ’›๐Ÿ’š
2/x Why did they do it? Because 1โƒฃ cancer patients are at high risk from covid ๐Ÿ“ˆ 2โƒฃ Many don't get an immune response to vaccines ๐Ÿ’‰ 3โƒฃ They wanted to find the scale of the problem ๐Ÿ’ฅ. So they decided to go global! ๐ŸŒ
3/x. The team searched 3065 papers published from the start of vaccination to March 2022. They looked at third dose boosters ๐Ÿ’‰. They looked across all cancer types. They found 15 studies encompassing 1205 patients๐Ÿง‘โ€๐Ÿคโ€๐Ÿง‘. The largest global review ๐ŸŒ
Read 11 tweets

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