If you have interest in how we wrestle with competing issues, trial designs, endpoints, and the type of difficult decisions that are made in drug development balancing the needs of the patient, efficacy, safety, etc this workshop will be educational.
The topics discussed will be relevant to all cancers and so those who are in other related fields of oncology will also find the workshop helpful.
MGUS shows up on a serum protein electrophoresis (PEL) as a spike. See figure. The spike is called an M spike.
It can be typed on immunofixation (IFE) to determine if it’s IgG or IgM or IgA; kappa or lambda. See below. 2/
MGUS was a term coined by Dr. Kyle.
He called It MGUS because prior to that it was called benign monoclonal gammopathy. Since he found a 1% per year risk of progression to myeloma he felt it the word “benign” may not capture the clinical implications adequately. 2/
We know COVID vaccine efficacy wanes over time. Even though protection is excellent against severe illness, you really don’t want to get COVID multiple times.
We know that new variants keep coming up. This bivalent booster targets omicron variants. Get the new booster. Please.
Really inexplicable why there are restrictions on why only those who have completed original series can get the bivalent vaccine.
Even I don’t know how people who haven’t completed the primary vaccine series get the original series or the new booster. Muddled messaging indeed.
After seeing vorinostat, panobinostat, elotuzumab, belantamab, venetoclax, melflufen, selinexor, ixazomib falter in myeloma, my thoughts on cancer drug development for investigators and Pharma. Simple. But simple is hard. 1/ #MedTwitter
Make sure as a company or investigator you are convinced of the single agent efficacy of your drug in phase II trials. If a drug is weak, needs steroids or something else to take it over the hump, even if it is approved, its likely to be a marginal drug that’s marginally used.
2/
Make sure the dosing schedule is realistic. If a drug is so weak that you think you have to give the most frequent dosing schedule possible so that you won’t miss efficacy benchmark on Phase III, the drug will not fare well in real life.
3/
Sept 25. 2 years since India lost one of the greatest singers ever: SPB
What can you do in 2 mins to highlight the divine talent of a man who recorded >40,000 songs? I made this video collage in memory of the legend. A dear friend. #SPBLivesOn@rameshlaus@PSampathkumarMD
Ilaya Nila. Made this by using original recording sound with live performances. The change from C#m (original recording) to Dm (live shows) gives the song a different flavor. I made this video to celebrate the original recording.