Teddy Hla Profile picture
Oct 23 18 tweets 6 min read
FINAL day 2 of 2 : WEANING . Lisanne Roesthuis. Weaning definitions starting with WIND study. #LIVES2022
#ventilation
#weaning #WeAreICU #TogetherICU #IntensiveCare #CriticalCare
@ESICM
@ESICM pubmed.ncbi.nlm.nih.gov/27626706/ Successful weaning (or successful separation) - extubation without death or reintubation within next 7 days. same for tracheostomy.
Different groups and trajectories
ABCDE of weaning
1. airway and lung (compliance, resistance and gas exchange)
2. Brain (delirium, cognitive dysfunction)
3. Cardiac (Echo, after load reduction )
4. Diaphragm (Pi max, early mobilisation)
5. Endocrine.(adequate energy intake )
pubmed.ncbi.nlm.nih.gov/21143773/
Very comprehensive. Essentially excellent holistic icu care
Q: How to perform SBT?
a). low PS and PEEP
b). low PS without PEEP
c). using cPAP(i.e., PEEP)
d). T-piece with o2 supply
What would you do ?
PS under-estimates TRUE respiratory effort. but SBT with PS is more successful. pubmed.ncbi.nlm.nih.gov/31184740/
pressure support can mask cardiac failure due to PS reducing LV after load.
Potentially gastric pressure monitoring can also give additional information. Eadi - measure electrical activity of the diaphragm - more commonly known as "NAVA"
NAVA levels set accordingly - e.g., 2cmH20 per micro volt. What is the effect of PS on EA di ? atsjournals.org/doi/pdf/10.116…
in the failure to wean - EA di signal tend to increase significantly.
pubs.asahq.org/anesthesiology…
pubmed.ncbi.nlm.nih.gov/23478659/

There is a correlation between EAdi and Pmusc. but the gold standard is "of course - the oesophageal catheter".
So a lot of info here. Using pressure time curves to calculate WOB. You can see even having an ascites would shift to more wOB
With this we end our 2 day workshop. Now opening ceremony in 2015.

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More from @teddyhla

Oct 25
Mariangela PELLEGRINI
Uppsala- Sweden
"Do we Need a biological definition of ARDS"

- Berlin definition has NO Diffuse alveolar damage .
- the Berlin defn does not capture well
Frohlich - different definitions specificity of 0.63, 0.42, 0.31 even!
#ventilation #ards #LIVES2022
academic.oup.com/bja/article/11…
The BJA article by Frohlich.
Fibrosis only starts after 7 days
Thille article : atsjournals.org/doi/full/10.11…
In essence, different disease processes are happening to the lung at different times in the "ARDS"
pubmed.ncbi.nlm.nih.gov/24429204/
Read 14 tweets
Oct 25
ARDS - new definition or phenotypes by @GicoBellani refreshing with Kigali definition of ARDS - useful not just low resource but during pandemic in supposedly high income settings and only draw back is no PEEp requirement #ards #ventilation #LIVES2022 @ESICM
@GicoBellani @ESICM Resolved versus confirmed ARDS
- prospectively applying Berlin definition did work but if ya wait 24 hrs and re-measure P/F ratio, you end up stratifying much better.
- Better separation of groups

pubmed.ncbi.nlm.nih.gov/29632996/
#ventilation #LIVES2022
@GicoBellani @ESICM Whichever definition - american european consensus or Berlin or Kigali -- all goes back to Ashbaugh original paper in 1967

thelancet.com/journals/lance…

Why are we so confused when it comes to ARDS definition ?

#ards #ventilation #LIVES2022 @ESICM
Read 11 tweets
Oct 25
Next : Mypinder SEKHON on cardiac arrest in COVID-19 era.

Works in Vancouver
COVID 19 era cardiac arrest ARE a lot less sexy with all the PPE. #als #covid19 #resuscitation #LIVES2022
@ESICM
@ESICM Let's look at epidemiology. Northern Italy, Manhattan - COVID hit hard and has impact on other diseases.

e.g., OHCA in Italy during COVID 19 massive spike.
ImageImageImage
Read 9 tweets
Oct 25
NEXT Speaker : VA ecmo for which patients?
Alain COMBES

Severe cardiogenic shock has different phenotypes
1. medical cardiogenic shock(AMI, end stage dilated CM, myocarditis, septic shock)
2. Post cardiotomy refractory CS (post CABG)
#LIVES2022
@ESICM #ecmo #resuscitation #ALS
@ESICM 2022 what do the guidelines say
- ESC recommends short term MCS should be considred in cardiogenic shock.
IABP may be considered but not routinely recommended in post MI
#LIVES2022
Image
Read 18 tweets
Oct 25
what about in refractory cardiac arrest?
ERC - ESICM guidelines 2021
- timing of CAG if no evidence ofr ST segment evaluation.

which means we will end up treating a lot of patients with stent and anticoagulation
TOMAHAWK trial : delayed or early invasive angiography -- no effec.

#LIVES2022
- immediate catheterisation for non ST elevationrr
Read 4 tweets
Oct 25
Updates on Advanced life supprot by Theresa OLASVEENGEN

Vasopressors and Drugs : recent trial outcomes.
#LIVES2022
@ESICM #als #resuscitation
@ESICM 2020 ILCOR consensus : strong recommendation to use "ADRENALINE" in cardiac arrest, if you dont have it "LIDOCAINE".

Adrenaline to placebo comparison is mainly 1 older trial with latest PARAMEDIC 2

pubmed.ncbi.nlm.nih.gov/30980877/
@ESICM PARAMEDIC 2 - big study
8007 pts, adrenaline 4000, placebo 3999
- a lot of discussion post trial
- need a nuanced interpretation.
- 19 "more good" survivors and 5 "more bad" survivors in adrenaline arm.

nejm.org/doi/full/10.10…
Read 19 tweets

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