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Helmi Sulaiman Profile picture
@edenhelmi
Nov 2, 2022 • 7 tweets • 7 min read • Read on X
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Myth: Bactericidal Agents Are Necessary for the Treatment of BSI at #idweek2022

A nice and easy-to-follow account of bactericidal vs. bacteriostatic agents and activity
@SyamhaninA @fikreeahmad @adammashraff @shaharudeen @andrewchangID @Rasidah @suraya_sudenia @cllau888
@SyamhaninA @fikreeahmad @adammashraff @shaharudeen @andrewchangID @Rasidah @suraya_sudenia @cllau888 Cidality is NOT an intrinsic property of an antibiotic
e.g., for the same drug (TMP-SMX), we have 2 different properties against 2 different organisms:
1) Static against Steno
2) Cidal against E. coli
@SyamhaninA @fikreeahmad @adammashraff @shaharudeen @andrewchangID @Rasidah @suraya_sudenia @cllau888 Here's the link to the slides:
dropbox.com/s/p6l8g4irl2dh…
And in a subgroup analysis of LNZ (a bacteriostatic agent), the data favors it over the bacteriocidal agents!

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More from @edenhelmi

Helmi Sulaiman Profile picture
Apr 28
SAB management updates by IDSA/ESCMID
#ESCMIDGlobal2024
The term “complicated” SAB varies and does not always suggest longer treatment
Solution: low vs. high-risk populations for SAB Image
How do we risk stratify SAB into the two levels? Image
How many sets of BC should be repeated?
1 or 2 sets
24 or 48 hours later Image
Read 13 tweets
Helmi Sulaiman Profile picture
Apr 10
A very enlightening talk by Angela Hutner on simple vs complicated UTI definitions
Simplicity wins
Anything that is beyond the bladder = complicated UTI (including prostatitis)

This will be updated in 2024 by both the IDSA and ESCMID

#IDTwitter #IDXposts
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IDSA/ESCMID new guidelines: Image
Gupta has updated this on UpToDate too Image
Read 32 tweets
Helmi Sulaiman Profile picture
Apr 17, 2023
New drugs against GNB by Ursula Theuretzbacher #ECCMID2023

In Malaysia, we only have Cefta-avi for resistant GNB infections!
We hope @SHIONOGI_JP will include Malaysia in the list of countries for generic cefiderocol- a project by @gardp_amr

@KKMPutrajaya @DrZalihaMustafa Image
These are the drugs that are recently approved and we have none of these locally
We can only use Fe-troja(n)/Cefiderocol by @SHIONOGI_JP under the compassionate use program, and the drug is flown all the way from Europe

The cost is huge and our patients can rarely afford it Image
Again, the same table:
The red ones are called DBO/Diazabicyclooctanes. They have an added PBP activity in addition to BLI activity
Boronates have extended BLI activity (MBL)
The green one is the Tazobactam analogue

Here is an excellent podcast on these: asm.org/Podcasts/Edito… Image
Read 17 tweets
Helmi Sulaiman Profile picture
Apr 16, 2023
Fairytales or reality, checking some eminence paradigms for treatment of severe infections

#ECCMID2023 Image
Kill fast! These infections must be treated with a "bactericidal" antibiotic
Beatrice Grabein, Germany

Clindamycin is bad for invasive MRSA infection
journals.asm.org/doi/full/10.11… Image
Tolerance to oxacillin is bad
ncbi.nlm.nih.gov/pmc/articles/P… Image
Read 29 tweets
Helmi Sulaiman Profile picture
Apr 15, 2023
Polymyxins and carbapenems: their place in the treatment of MDR Gram-negative infection today
#ECCMID2023

This a very relevant talk for us in Southeast Asia (exc Singapore)

@alif82 @SyamhaninA @fikreeahmad @shaharudeen @GSRajahram @stevenlimcl @SazaliBasri @HanzHc
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Read 19 tweets
Helmi Sulaiman Profile picture
Apr 15, 2023
Evolution of CM/ID Specialties by Dr. Rama
#ECCMID2023 Image
He talked about his evolution when he came back from the US and the UK
He needed to learn about the cultures in India

This includes antibiotics as a one-size-fits-all remedy

He captured the issues of empiric therapies - one empiric regimen after another. Image
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Read 9 tweets

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