Some classic genetic stories, and some more recent ones… #TLM22 
Samer Gawrieh now on interaction of #ALD and #NAFLD - HOMA-IR strongest risk for incr histological severity of ALD #TLM22
* in that analysis
@NoureddinMD now on the rapidly shifting landscape of noninvasive biomarkers for #NASH #NAFLD, complete with a health warning for the number of slides #TLM22
NIS4 and FAST scores for identifying at risk NASH, read the studies here: thelancet.com/journals/langa… thelancet.com/journals/langa… #TLM22
How to put it all together? Perhaps like this #TLM22
@MajaThiele now gives the #ALD noninvasive test perspective, beginning with a summary of biomarkers for severe fibrosis - good TE and ELF performance #TLM22
Optimal TE cutoffs vary markedly by study, perhaps due to spectrum bias and active inflammation - data from this 2018 IPD-MA thelancet.com/journals/langa… #TLM22
So what cutoff to use? Thiele suggests rule of five #TLM22
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