Can we trust PhDs?

1/ Claim: "No upper limit (UL) has been set for linoleic acid because of a lack of a defined intake establishing adverse affects (2)."

Reference 2: “An upper boundary for linoleic acid is set at 10 percent of energy for three reasons: ...(3) high intakes
2/ "...of linoleic acid create a pro-oxidant state that may predispose to several chronic diseases, such as CHD and cancer."

Read both snapshots.

Hat tip to @MDVilntfluid for getting me to take another look at Whelan.

#lcl6
3/3 Claim in: "Linoleic Acid" doi.org/10.3945/an.113…

Ref 2: "Dietary Reference Intakes for ...Fat, Fatty Acids..." nap.edu/catalog/10490/…
More. From same authors:

"The consumption of linoleic acid in the US diet began to increase around 1969 and paralleled the introduction of soybean oil as the major commercial additive to many processed foods (4)."

1909-1969 +100% increase.
After 1969 +25% increase.

Ref. 4.
What the heck turns you into a pro-seed oil propagandist?

nutrition.utk.edu/people/jay-whe…

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More from @TuckerGoodrich

Oct 17
#COVID19 wasn't bad enough. This is #Fauci's parting gift...

1/ "We generated chimeric recombinant SARS-CoV-2 encoding the S gene of Omicron in the backbone of an ancestral SARS-CoV-2 isolate and compared this virus with the naturally circulating Omicron variant..."
2/ "The Omicron S-bearing virus robustly escapes vaccine-induced humoral immunity, mainly due to mutations in the receptor-binding motif (RBM), yet unlike naturally occurring Omicron, efficiently replicates in cell lines and primary-like distal lung cells."
3/ "In K18-hACE2 mice, while Omicron causes mild, non-fatal infection, the Omicron S-carrying virus inflicts severe disease with a mortality rate of 80%."
Read 6 tweets
Oct 5
1/ So apparently one thing folks didn't like about my discussion with @haidut was my bringing up the subject of organ failure with a low-fat, low-calorie, high-carb diet. (according to the Youtube comments, anyway.)
2/ So:

"After 8 weeks of dieting sludge was detected in 3 subjects and gallstones in 13(25.5%). In contrast, none of the nondieting subjects developed any detectable gallbladder abnormalities.
3/ "We conclude that this form of weight-reduction dieting predisposes to the development of gallstones and that gallstone formation is a risk of this type of prolonged calorie restriction.
Read 8 tweets
Oct 5
1/4 Canola (rapeseed) oil is one of the better seed oils, it's ~20% linoleic acid.

But it still goes rancid (toxic), because it contains linoleic acid.

Safest and healthiest fats/oils to eat are low in linoleic acid!

@ZeroAcreFarms #lcl6 Image
2/4 "Triacylglycerol (TG), the main component of edible oil, is oxidized by thermal- or photo- oxidation to form TG hydroperoxide (TGOOH) as the primary oxidation product.
3/4 "Since TGOOH and its subsequent oxidation products cause not only the deterioration of oil quality but also various toxicities, preventing the oxidation of edible oils is essential."
Read 4 tweets
May 9
1/ Why do CETP inhibitors fail to improve CVD outcomes?

en.wikipedia.org/wiki/CETP_inhi…

@ethanweiss #lcl6 @FatEmperor @LDLSkeptic
2/ (They work by increasing HDL in the blood. HDL is supposed to be the "good" cholesterol.)
3/ But HDL is "good" because it uses CETP to remove the "bad" fats from LDL. These bad fats are overwhelmingly oxidized LA-cholesterol esters.

#lcl6
Read 10 tweets
Feb 24
1/4 So what change is the likely cause of our dietary woes?

"From 1909 to 2010, total availability per capita for animal-based fats (including butter, lard, edible tallow) decreased 58% (21.2–8.8 lbs.) and vegetable-based fats and oils (margarine, shortening, salad, and...
2/4 "...cooking oils (included only after 1965), and edible fats and oils found in confectionery products and non-dairy creamers) increased 159% (31.7–82.2 lbs.)."
3/4 "As observed... processed and ultra-processed foods dramatically increased over the past two centuries, especially sugar, white flour, white rice, vegetable oils... These changes paralleled the rising incidence of NCDs, while animal fat consumption was inversely correlated."
Read 4 tweets
Dec 23, 2021
1/4 Paradox!

CVD & CHD Mortality by CAC, Statins vs No Statins.

'Surprising' is an understatement...

@realDaveFeldman @FatEmperor @nicknorwitz @DoctorTro @LDLSkeptic @DrAseemMalhotra
2/4 "Prognostic value of coronary artery calcium score, area, and density among individuals on statin therapy vs. non-users: The coronary artery calcium consortium"

atherosclerosis-journal.com/article/S0021-…
3/4 "Complicating interpretation is the inclusion of only fatal events and the relatively elevated, but still low, mortality rate in statin users versus non-users with a zero CAC score."
Read 5 tweets

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