Thread by @rheum_cat

#ACR22 #IgniteTalks 6C
Will be presented live Sun Nov 13 at 2pm

🌟Abs 1785 Bartlett, et al.
❓Research Q: Among individuals with RA with depression, where there distinct groups with clear trajectories in terms of their PROs?

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Abs 1785 used:
🔹the Canadian Early Arthritis Cohort (RA)
🔹group-based trajectory modeling (GBTM) to identify clusters with similar trajectories in terms of PROs before & during the pandemic

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Abs 1785, results

4 latent groups identified:
1️⃣resilient
2️⃣worsening
3️⃣improving
4️⃣persistent

The group with worsening PROs had a higher % of women, higher BMI, higher disease activity at baseline

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🌟Abs 1195 Chung, et al.
❓Research Q: Is duloxetine use a/w ⬆MACE among those with non-cancer chronic pain?

Data from Medicare 2015-2018
💔MACE = AMI and/or CVA

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Abs 1195, cont'd

They used a new user, active comparator design: new users of duloxetine compared with new users of gabapentin
📌pubmed.ncbi.nlm.nih.gov/25800216/

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Abs 1195, cont'd

📌They also used time-dependent propensity scores, which can account for depletion of susceptibles
They used these propensity scores to calculate IPWs

👉they found a null association between new duloxetine use (vs gabapentin use) & MACE risk
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🌟Abs 0711 Soussi, et al.
Danish pop-based matched cohort study
❓Research Q: Has the 5-yr mortality risk in individuals with RA improved over time?

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Abs 0711 cont'd

📈RA matched to non-RA comparators
RD & RR calculated for age-adjusted all-cause mortality

RA mortality (vs non RA): ⬆
RD & RR both ⬇over time - likely w improved RA tx

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🌟Abs 0707 Galvao, et al.
❓Research Q: Are glucocorticoid claims data accurate?

Data: 🔗Medicare claims 2006-2015 linked with CorEvitas

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Abs 0707 cont'd

📌The other interesting part of this abstract is their deterministic sensitivity analysis, to reanalyze GC exposure & infx risk, but to determine how the results change with misclassification of GC exposure

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🌟Abs 0713 @zach_wallace_md
epidemiology of IgG4RD in Optum 2015-2019

n=524 + matched comparators
IgG4: ⬆ comorbidities, ⬆ healthcare utilization

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@zach_wallace_md Abs 0713, cont'd

Organ involvement: pancreas > biliary tree > salivary glands

💊Treatment: steroids >> AZA, RTX > others

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@zach_wallace_md 🌟Abs 1774 @xbaraliakos
descriptive study of an early triage system for rheumatology

1️⃣health professional contact
2️⃣10 min rheum eval
3️⃣eval for final dx

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@zach_wallace_md @XBaraliakos Abs 1774 cont'd

📊n=972 seen in this triage pathway
13% dx RA, 7% dx SpA including PsA

#ACR22