Thread by @rheum_cat

.@DPatWCorrigan with #MOST data @kecostello @ProfCaraLewis @MikeLaValley8 @tuhina_neogi @patellaprof @BU_BMC_Rheum

oral in the LBP/ortho/rehab session

#ACR22

@DPatWCorrigan @kecostello @ProfCaraLewis @MikeLaValley8 @Tuhina_Neogi @patellaprof @BU_BMC_Rheum Individuals with unilateral symptomatic knee OA commonly walk in a way that unloads their knee with OA

This unloading can relieve pain, but may shift the load in such a way to increase risk of OA in the contralateral knee

#ACR22

@DPatWCorrigan @kecostello @ProfCaraLewis @MikeLaValley8 @Tuhina_Neogi @patellaprof @BU_BMC_Rheum This study aimed to explore relations between *ground reaction force symmetry metrics* and *cartilage worsening in the contralateral knee* in persons with unilateral knee OA

#ACR22

Data from #MOST

Included participants with unilateral KOA with available gait data

Gait data (exposure) at 144m visit
MRI data from 144m and 168m visits

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For those unfamiliar, this was how gait data were collected in #MOST

🚶‍♀️3D ground reaction forces were acquired with a force plate

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More detail on gait assessment parameters of interest (the exposure)

To quantify symmetry metrics for each variable, calculated symmetry angles

0 = perfect symmetry
100 = equal & opposite between limbs

negative values indicate greater force on the limb with knee OA

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Outcome: cartilage worsening by MOAKS on knee MRI

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for n=100

Overall, forces were symmetric and similar between outcome groups

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In MVA, a 1 SD increase in medial impulse symmetry angle was significantly a/w 42% decreased odds of cartilage worsening in the contralateral knee

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In conclusion

👉ground reaction force symmetry metrics are NOT associated with ⬆️ cartilage worsening in the contralateral knee for those with unilateral knee OA

#ACR22