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Nov 12, 2022 10 tweets 10 min read Read on X
@DPatWCorrigan @kecostello @ProfCaraLewis @MikeLaValley8 @Tuhina_Neogi @patellaprof @BU_BMC_Rheum Individuals with unilateral symptomatic knee OA commonly walk in a way that unloads their knee with OA

This unloading can relieve pain, but may shift the load in such a way to increase risk of OA in the contralateral knee

#ACR22
@DPatWCorrigan @kecostello @ProfCaraLewis @MikeLaValley8 @Tuhina_Neogi @patellaprof @BU_BMC_Rheum This study aimed to explore relations between *ground reaction force symmetry metrics* and *cartilage worsening in the contralateral knee* in persons with unilateral knee OA

#ACR22
Data from #MOST

Included participants with unilateral KOA with available gait data

Gait data (exposure) at 144m visit
MRI data from 144m and 168m visits

#ACR22
For those unfamiliar, this was how gait data were collected in #MOST

🚶‍♀️3D ground reaction forces were acquired with a force plate

#ACR22
More detail on gait assessment parameters of interest (the exposure)

To quantify symmetry metrics for each variable, calculated symmetry angles

0 = perfect symmetry
100 = equal & opposite between limbs

negative values indicate greater force on the limb with knee OA

#ACR22
Outcome: cartilage worsening by MOAKS on knee MRI

#ACR22
for n=100

Overall, forces were symmetric and similar between outcome groups

#ACR22
In MVA, a 1 SD increase in medial impulse symmetry angle was significantly a/w 42% decreased odds of cartilage worsening in the contralateral knee

#ACR22
In conclusion

👉ground reaction force symmetry metrics are NOT associated with ⬆️ cartilage worsening in the contralateral knee for those with unilateral knee OA

#ACR22

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More from @rheum_cat

Nov 13, 2022
#ACR22 social media talk, very meta
Part 1️⃣: optimize your conference tweeting
If you're reading this you probably know all of this!

The first pro-tip was figure out the conference hashtag
The second? Engage with others in rheum
#ACR22
What else?

👉amplify your group
👉amplify speakers and sessions of interest
👉amplify your colleagues so they will amplify you in turn

#ACR22
Read 10 tweets
Nov 13, 2022
#ACR22 infection (COVID) posters Image
Abs 0784 @CCalabreseDO

Cleveland Clinic breakthrough infections, including data on n=21 who received Evusheld

📌Publication here: pubmed.ncbi.nlm.nih.gov/35791921/

#ACR22
@CCalabreseDO Abs 0779 @CCalabreseDO

Experience with evusheld PrEP with IMID on BCDT at Cleveland Clinic

📌Publication here: pubmed.ncbi.nlm.nih.gov/36123015/

#ACR22
Read 13 tweets
Nov 13, 2022
The EULAR e posters were tiny (bad) but speakers could zoom in and out (good)

That would have been nice for #IgniteTalks #ACR22
The sound is adequate though. EULAR issue was that the sound was poor in their (smaller) poster tour stages #ACR22 #IgniteTalk
Read 4 tweets
Nov 13, 2022
#ACR22 epidemiology posters Image
Abs 0700 @zach_wallace_md
💻Using NLP, ML algorithms to identify ANCA vasculitis cases

They also looked at the difference in performance metrics with/without filtering keywords

An explosion of NLP studies in rheum! #ACR22
@zach_wallace_md Abs 0732 Ho, et al. @JYazdanyMD @MilenaGianfran
💻Part of the explosion of NLP studies in rheum

Here the UCSF group aimed to capture VZV cases (differentiate from vaccination); and to capture active vs historical cases

See their diagrams explaining the steps!
#ACR22
Read 13 tweets
Nov 13, 2022
We have learned quite quickly that a virtual ONLY poster hall mixed into a hybrid meeting doesn't work well.

Poor wifi and the crashing platform compound the problem

And if it's online ONLY, is that truly hybrid?

#ACR22
This is not a complaint thread. I am hoping we can have discussion about what works/doesn't work, and what could be done next year for #ACR23
It goes without saying that an in-person poster hall is the most requested item on the wishlist for #ACR23

@GrantSchulert @Tuhina_Neogi
Read 5 tweets
Nov 13, 2022
Biostatician @MikeLaValley8 @BU_BMC_Rheum presents a quick overview on how to appropriately interpret results from studies #ACR22

Of course this is not an exhaustive deep dive, but covers some common errors of interpretation Image
@MikeLaValley8 @BU_BMC_Rheum First, what is your research question? What is the question you are trying to answer with t he study?

👉Does this exposure CAUSE this outcome?

#ACR22 Image
@MikeLaValley8 @BU_BMC_Rheum What are common observational study designs and what are big issues to watch out for?

These are issues that can affect the validity of their results.

There are more potential issues within these study designs that is beyond the scope of this table

#ACR22 Image
Read 15 tweets

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