Thread by @rheum_cat

#ACR22 infection (COVID) posters

Abs 0784 @CCalabreseDO

Cleveland Clinic breakthrough infections, including data on n=21 who received Evusheld

📌Publication here: pubmed.ncbi.nlm.nih.gov/35791921/

#ACR22

@CCalabreseDO Abs 0779 @CCalabreseDO

Experience with evusheld PrEP with IMID on BCDT at Cleveland Clinic

📌Publication here: pubmed.ncbi.nlm.nih.gov/36123015/

#ACR22

@CCalabreseDO Abs 0783 @Yuz6Yusof

breakthrough infection in ARDs on RTX n=365

factors a/w time to infx:
number of comorbidities
low IgG levels

💉reaffirms that vaccination = protective

#ACR22

@CCalabreseDO @Yuz6Yusof Abs 0797 Frey, et al. @JuliePaikMD

n=220 on MMF
>no hold: 177
>hold <10 days: 21
>hold >=10 days: 22

longer MMF hold a/w ⬆Ab response; no diff in flares

Simple stats, no MVA, clear message 👍

#ACR22

@CCalabreseDO @Yuz6Yusof @JuliePaikMD Abs 0797 cont'd

📌See the prior data from Hopkins on MMF hold & immunogenicity here:pubmed.ncbi.nlm.nih.gov/34556484/

#ACR22

@CCalabreseDO @Yuz6Yusof @JuliePaikMD Abs 0796 Saad, et al
💉Brazilian study of 3rd dose of Coronavac in n=196 SpA pts + n=183 controls

TNFi use: ⬇Ab response (we've seen this repeatedly)

#ACR22

@CCalabreseDO @Yuz6Yusof @JuliePaikMD Abs 0796 cont'd

But,
SSZ use: ⬆Ab response
SSZ+TNFi combo: similar Ab response to controls

👉The authors infer that SSZ use may counteract the decreased immunogenicity of TNFi following COVID vaccination
🤔MoA?

#ACR22

@CCalabreseDO @Yuz6Yusof @JuliePaikMD Abs 0794 @NaomiRheumMD
vaccination & PASC (defined as sx>28 days after COVID)

n=251 SARD + COVID

📊They looked at % of PASC in those with/without breakthrough infx (defined as infx after 2 doses)

#ACR22

@CCalabreseDO @Yuz6Yusof @JuliePaikMD @NaomiRheumMD Abs 0794 cont'd

👉They found that those vaccinated had numerically lower % with PASC
Larger sample needed to confirm

📌For other work on PASC: pubmed.ncbi.nlm.nih.gov/36104117/

#ACR22

@CCalabreseDO @Yuz6Yusof @JuliePaikMD @NaomiRheumMD Abs 0795 Mukherjee, et al.
2 prospective cohorts from McMaster:

1️⃣n=58 PCR+ SARS-CoV-2. In these 30% snRNP+, 21% SSB+ and serologies correlated with persistent sxs

#ACR22

@CCalabreseDO @Yuz6Yusof @JuliePaikMD @NaomiRheumMD Abs 0795 cont'd

2️⃣n=58 PASC, with 6 having new rheum diagnoses

On the lookout for data from other prospective cohorts of this nature 🔎 -- do we have concordant or discordant results?

#ACR22

@CCalabreseDO @Yuz6Yusof @JuliePaikMD @NaomiRheumMD Abs 0791 Jyssum, et al.
Norvac study, 3rd dose of vaccine 💉💉💉
n=1100 IMID

factors a/w ⬆Ab response:
>med holding
>MTX use (!)

#ACR22