Thread by @TuckerGoodrich

1/ "Only a few previous studies have examined head-to-head the extent of excess risk explained through high concentrations of remnant cholesterol or triglycerides (substitute markers for high VLDL cholesterol) and high concentrations of LDL cholesterol separately...

2/ "...(18, 19), and none have used directly measured concentrations of both VLDL cholesterol and LDL cholesterol. Consequently, it is presently unknown to what extent directly measured cholesterol in large and small VLDLs, in IDL, and in LDL in head-to-head comparison...

3/ "...each explain excess risk of myocardial infarction in individuals with obesity."

This is from 2021, mind you. 🙄

4/ "...Cholesterol in large and small VLDLs combined explained 40%... of the excess risk of myocardial infarction associated with higher BMI. In contrast, IDL and LDL cholesterol did not explain excess risk of myocardial infarction,...

So LDL doesn't do anything? 😱🙄

5/ "...whereas systolic blood pressure explained 17% (11%–23%) and diabetes mellitus explained 8.6% (3.2%–14%)."

6/ It's important to note they're including chylomicron remnants in VLDL, and thus dietary fat, although the authors seem to be unaware of this.

7/7 "Very Low-Density Lipoprotein Cholesterol May Mediate a Substantial Component of the Effect of Obesity on Myocardial Infarction Risk: The Copenhagen General Population Study"

doi.org/10.1093/clinch…

#lcl6 @FatEmperor