1/ "Only a few previous studies have examined head-to-head the extent of excess risk explained through high concentrations of remnant cholesterol or triglycerides (substitute markers for high VLDL cholesterol) and high concentrations of LDL cholesterol separately...
2/ "...(18, 19), and none have used directly measured concentrations of both VLDL cholesterol and LDL cholesterol. Consequently, it is presently unknown to what extent directly measured cholesterol in large and small VLDLs, in IDL, and in LDL in head-to-head comparison...
3/ "...each explain excess risk of myocardial infarction in individuals with obesity."

This is from 2021, mind you. 🙄
4/ "...Cholesterol in large and small VLDLs combined explained 40%... of the excess risk of myocardial infarction associated with higher BMI. In contrast, IDL and LDL cholesterol did not explain excess risk of myocardial infarction,...

So LDL doesn't do anything? 😱🙄
5/ "...whereas systolic blood pressure explained 17% (11%–23%) and diabetes mellitus explained 8.6% (3.2%–14%)."
6/ It's important to note they're including chylomicron remnants in VLDL, and thus dietary fat, although the authors seem to be unaware of this.
7/7 "Very Low-Density Lipoprotein Cholesterol May Mediate a Substantial Component of the Effect of Obesity on Myocardial Infarction Risk: The Copenhagen General Population Study"

doi.org/10.1093/clinch…

#lcl6 @FatEmperor

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More from @TuckerGoodrich

Nov 6
Can we trust PhDs?

1/ Claim: "No upper limit (UL) has been set for linoleic acid because of a lack of a defined intake establishing adverse affects (2)."

Reference 2: “An upper boundary for linoleic acid is set at 10 percent of energy for three reasons: ...(3) high intakes
2/ "...of linoleic acid create a pro-oxidant state that may predispose to several chronic diseases, such as CHD and cancer."

Read both snapshots.

Hat tip to @MDVilntfluid for getting me to take another look at Whelan.

#lcl6
3/3 Claim in: "Linoleic Acid" doi.org/10.3945/an.113…

Ref 2: "Dietary Reference Intakes for ...Fat, Fatty Acids..." nap.edu/catalog/10490/…
Read 5 tweets
Oct 17
#COVID19 wasn't bad enough. This is #Fauci's parting gift...

1/ "We generated chimeric recombinant SARS-CoV-2 encoding the S gene of Omicron in the backbone of an ancestral SARS-CoV-2 isolate and compared this virus with the naturally circulating Omicron variant..."
2/ "The Omicron S-bearing virus robustly escapes vaccine-induced humoral immunity, mainly due to mutations in the receptor-binding motif (RBM), yet unlike naturally occurring Omicron, efficiently replicates in cell lines and primary-like distal lung cells."
3/ "In K18-hACE2 mice, while Omicron causes mild, non-fatal infection, the Omicron S-carrying virus inflicts severe disease with a mortality rate of 80%."
Read 6 tweets
Oct 5
1/ So apparently one thing folks didn't like about my discussion with @haidut was my bringing up the subject of organ failure with a low-fat, low-calorie, high-carb diet. (according to the Youtube comments, anyway.)
2/ So:

"After 8 weeks of dieting sludge was detected in 3 subjects and gallstones in 13(25.5%). In contrast, none of the nondieting subjects developed any detectable gallbladder abnormalities.
3/ "We conclude that this form of weight-reduction dieting predisposes to the development of gallstones and that gallstone formation is a risk of this type of prolonged calorie restriction.
Read 8 tweets
Oct 5
1/4 Canola (rapeseed) oil is one of the better seed oils, it's ~20% linoleic acid.

But it still goes rancid (toxic), because it contains linoleic acid.

Safest and healthiest fats/oils to eat are low in linoleic acid!

@ZeroAcreFarms #lcl6 Image
2/4 "Triacylglycerol (TG), the main component of edible oil, is oxidized by thermal- or photo- oxidation to form TG hydroperoxide (TGOOH) as the primary oxidation product.
3/4 "Since TGOOH and its subsequent oxidation products cause not only the deterioration of oil quality but also various toxicities, preventing the oxidation of edible oils is essential."
Read 4 tweets
May 9
1/ Why do CETP inhibitors fail to improve CVD outcomes?

en.wikipedia.org/wiki/CETP_inhi…

@ethanweiss #lcl6 @FatEmperor @LDLSkeptic
2/ (They work by increasing HDL in the blood. HDL is supposed to be the "good" cholesterol.)
3/ But HDL is "good" because it uses CETP to remove the "bad" fats from LDL. These bad fats are overwhelmingly oxidized LA-cholesterol esters.

#lcl6
Read 10 tweets
Feb 24
1/4 So what change is the likely cause of our dietary woes?

"From 1909 to 2010, total availability per capita for animal-based fats (including butter, lard, edible tallow) decreased 58% (21.2–8.8 lbs.) and vegetable-based fats and oils (margarine, shortening, salad, and...
2/4 "...cooking oils (included only after 1965), and edible fats and oils found in confectionery products and non-dairy creamers) increased 159% (31.7–82.2 lbs.)."
3/4 "As observed... processed and ultra-processed foods dramatically increased over the past two centuries, especially sugar, white flour, white rice, vegetable oils... These changes paralleled the rising incidence of NCDs, while animal fat consumption was inversely correlated."
Read 4 tweets

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