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Samer Al Hadidi, MD,MS,FACP Profile picture
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Nov 15 • 6 tweets • 3 min read
#MedTwitter #HemeBoards @HemOncFellows
🧵Summary of erythrocytes inclusion bodies:

1️⃣Howell-Jolly body
➡️composition: DNA
🔬associations: splenectomy, hyposplenism, megaloblastic anemia, hemolytic anemia, sickle cell disease Image
2️⃣Basophilic stippling
➡️composition: RNA
🔬associations: lead intoxication, thalassemia, abnormal heme synthesis Image
3️⃣Pappenheimer bodies
➡️composition: iron
🔬associations: splenectomy, hemolytic anemia, sideroblastic anemia, megaloblastic anemia, hemoglobinopathies Image
4️⃣Cabbot ring
➡️composition: remanent of mitosis spindle
🔬associations: MDS, megaloblastic anemia, AML Image
5️⃣Heinz body
➡️composition: unstable haemoglobin
🔬associations: unstable hemoglobin, G6PD deficiency and other erythrocytes enzyme deficiency, some hemoglobinopathies, alpha thalassemia Image
6️⃣Hemoglobin H
➡️composition: beta chain tetramers
🔬associations: a type of alpha thalassemia
End🧵 Image

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More from @HadidiSamer

Samer Al Hadidi, MD,MS,FACP Profile picture
Jun 26
#mmsm Hematologica published 3 articles for sub-group analysis for Isatuximab recently:
1-IKEMA pts with renal failure-Full article
2- ICARIA-MM elderly pt-letter to editor
3-IKEMA+ICARIA-MM: 1q-letter to editor
🛑All used 1-2 medical writers
Was this all the story ? 🧵
Same medical writers helped in a review of key subgroup analysis of ICARIA-MM 👇

Also in doing another subgroup analysis in high risk cytogenetics
You think we are done: NO

ICARIA-MM subgroup analysis 👇

Expert review article with the help of medical writer 👇
Read 12 tweets
Samer Al Hadidi, MD,MS,FACP Profile picture
Dec 4, 2021
#ASH21 Oral abstract:Ciltacabtagene Autoleucel for Triple-Class Exposed MM:Adjusted Comparisons of CARTITUDE-1 Patient Outcomes Versus Therapies from Real-World Clinical Practice from the LocoMMotion Prospective Study #mmsm 🧵
➡️ash.confex.com/ash/2021/webpr…
🛑some important issues👇
#ASH21 #mmsm
➡️Cilta Cel is effective in difficult to ttt pts, this is not the aim of the discussion
➡️In this abstract,authors compared a prospectively matched triple class ref MM pts who received diff ttt vs Cilta cel
➡️ what did they find? 👇 (Cilta Cel better) but wait🛑 Image
➡️Read results 👇
1️⃣countries:only 9% RWCP in US vs. 100% of pts who got Cilta Cel in CARTITUDE-1 were in US (16 Center) ➡️study compared pts across the ocean with diff access to ttt🙈
2️⃣>90 ttt options😅
3️⃣2 of the most frequently used regimens were doublet 🙈Kd (~14%),Pd (11%) Image
Read 6 tweets
Samer Al Hadidi, MD,MS,FACP Profile picture
Apr 30, 2021
Analyzing this study of defibrotide in VOD after transplant from Spain @amarkelkar @AkshaySharmaMD @hmgcoa2
➡️Link:tandfonline.com/doi/full/10.10… (accepted, not final)
➡️ Price data from Spain with €2019
➡️ FDA approved (March 30, 2016): fda.gov/drugs/resource…
➡️ VOD (~15% ,all types): a bad complication with high mortality (severe type, historically >80%)
➡️ Diagnosis &grading(see tables👇) (nature.com/articles/bmt20…)
➡️Authors question: is defibrotide cost-effective using price input from Spain (note this is likely different from US)
➡️ Simplified definitions:
1⃣ Cost-effectiveness analysis(CEA) is usually measured by incremental cost-effectiveness ratio (ICER) and it establishes how much extra has to be paid for extra benefit.
Read 14 tweets
Samer Al Hadidi, MD,MS,FACP Profile picture
Apr 3, 2021
Summary of cytoplasm/nucleus changes in leukocytes:
1️⃣ Hyposegmentation of neutrophils(peanut shaped, bilobed,or non-segmented nucleus with coarse chromatin)
🔬associations: Pelger–Huët anomaly(inherited) or pseudo-Pelger–Huët anomaly(acquired)

#MedTwitter @ASH_hematology #Heme ImageImageImage
➡️Pelger–Huët anomaly(inherited):affect majority of granulocytes: autosomal dominant- mutations in the lamin B receptor gene
➡️Pseudo-Pelger–Huët anomaly(acquired): <50% of granulocytes: usually occurs with other morphological changes of malignancy: can see in MPNs or MDS
#Heme Image
2️⃣Hypersegmentation of neutrophils
➡️≥ 6 lobes in granulocyte nucleus
🔬associations: megaloblastic anemia, chronic infections, MDS, familial(rare)
#Heme ImageImage
Read 8 tweets

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