Thread by @GourlaySyd

“Never-ending waves of severe #COVID19 disease”

How do we get out of this mess? Physical measures (masks, ventilation, HEPA filters …)

PLUS: ‘#NasalSpray’ strategies:
1️⃣ disable virus
2️⃣ disable host entry point (nasal ACE2 receptors)
3️⃣ boost nasal antibodies (secretary IgA)

1️⃣ Melbourne trial of nasal Heparin spray to disable virus spikes (necessary for access yo host cells):

premier.vic.gov.au/covid-nasal-sp…

2️⃣ Cold Atmospheric Plasma (CAP) ions disable host entry point (nasal ACE2 receptors):

tri.edu.au/news/could-the…

3️⃣ Although it sounds promising, there’s not much success yet with nasal-administered vaccines to boost nasal mucosal antibodies (secretary IgA or SIgA). Study using Oxford University ChAdOx1 (also used in original Astrazeneva vaccine):

nature.com/articles/d4159…

*to* host cells