Thread by @theneurolander

Polyminimyoclonus!!!

“intermittent, low-amplitude, arrhythmic movements of the hands, with amplitudes just sufficient to produce visible movements of the joints.”

American child neurologist Alfred J. Spiro (1930–2019)

#MedTwitter #neurotwitter #EndNeurophobia #tweetorials

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Features

- Mostly noticed when maintaining a posture (outstretched hands) or during action (initial phase of the movement)

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Pathophysiology @JackyGanguly

Motor cortex
- execution of fractionated muscle activation

Anterior horn cells
- generators of complex fasciculation

Possible role of brainstem, cerebellum, and basal ganglia

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How to clinically differentiate peripheral from central origin?

EEG & EMG

Peripheral: denervation
Central: parkinsonism or epilepsy

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Polyminimyoclonus: Hirayama disease

“low amplitude, intermittent, arrhythmic”

dx.doi.org/10.1136/bcr-20… via: BMJ Case Reports

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Polyminimyoclonus: Hirayama disease

“low amplitude, intermittent, arrhythmic”

dx.doi.org/10.1136/bcr-20… via: BMJ Case Reports

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Polyminimyoclonus: Spinal muscular atrophy type-3 (Kugelberg–Welander disease)

“low amplitude, intermittent, arrhythmic”

doi.org/10.1136%2Fbcr-… via: BMJ Case Reports

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Polyminimyoclonus: Spinal muscular atrophy

“low amplitude, intermittent, arrhythmic”

doi.org/10.1016/j.pedi… via: Pediatric neurology

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Polyminimyoclonus: Chronic Aluminium Toxicity

“low amplitude, intermittent, arrhythmic”

doi.org/10.5334%2Ftohm… via: Tremor Other Hyperkinet Mov (N Y)

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Polyminimyoclonus: Hirayama disease

“low amplitude, intermittent, arrhythmic”

doi.org/10.1007/s13760… via: Acta Neurol Belg

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Polyminimyoclonus: Progressive myoclonic ataxia

“low amplitude, intermittent, arrhythmic”

polymyoclonus and postural tremor

doi.org/10.1016/j.park… via: Parkinsonism Relat Disord

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Polyminimyoclonus

“low amplitude, intermittent, arrhythmic”

youtube.com/shorts/IXvFByD… via: Dr Sudhir Kumar

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Polyminimyoclonus

“low amplitude, intermittent, arrhythmic”

via: Dr. Vijaya Mishra

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Polyminimyoclonus: Myoclonus Renal Failure Syndrome

“low amplitude, intermittent, arrhythmic”

postural tremor, action myoclonus, and polyminimyoclonus

via: JAMA Network

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Polyminimyoclonus: Congenital myoclonus syndrome

“low amplitude, intermittent, arrhythmic”

youtube.com/shorts/Ps9zHOt… via: Daniel Jones

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Polyminimyoclonus: Renal failure syndrome

“low amplitude, intermittent, arrhythmic”

via: Daniel Jones

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Polyminimyoclonus: Hallermann-Streiff syndrome

“low amplitude, intermittent, arrhythmic”

via: Daniel Jones

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Polyminimyoclonus

“low amplitude, intermittent, arrhythmic”

via: Neurozone videos

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Polyminimyoclonus: Hirayama disease

“low amplitude, intermittent, arrhythmic”

via: Neurology Journal

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Polyminimyoclonus

“low amplitude, intermittent, arrhythmic”

youtube.com/shorts/geFfzqo… via: Ndd Workshop

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Polyminimyoclonus

“low amplitude, intermittent, arrhythmic”

postural tremor and polyminimyoclonus

youtube.com/shorts/d5f6tyI… via: Tech, Med & More

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Polyminimyoclonus: Morvan syndrome

“low amplitude, intermittent, arrhythmic”

via: The Lancet

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Polyminimyoclonus

“low amplitude, intermittent, arrhythmic”

youtube.com/shorts/kisJVUd… via: Dr.M. A Aleem

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Polyminimyoclonus: Myoclonus-dystonia syndrome

“low amplitude, intermittent, arrhythmic”

postural tremor, action myoclonus, polyminimyoclonus

youtube.com/shorts/qgcnI0_… via: Hannah Émile

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