Excited to share our publication in @CellRepMed highlighting #neutrophil activation in #PostCovid #MISC!
Led by @bpboribong and Tom LaSalle (@harvardmed), plus coauthors @D__Irimia, @EdlowLab and more
cell.com/cell-reports-m…
@MGH_RI @MGH_Mucosalists @ragoninstitute @MassCPR
Led by @bpboribong and Tom LaSalle (@harvardmed), plus coauthors @D__Irimia, @EdlowLab and more
cell.com/cell-reports-m…
@MGH_RI @MGH_Mucosalists @ragoninstitute @MassCPR
Key points:
-even in mild Pedi COVID, neutrophils display IFN signaling
-Neutrophils in MISC show sepsis-like gene expression: high degranulation, TNF and IL-1 signaling
-Neutrophils in MISC *spontaneously* form #NETS intravascularly (can’t be good…)
(Read on…)
-even in mild Pedi COVID, neutrophils display IFN signaling
-Neutrophils in MISC show sepsis-like gene expression: high degranulation, TNF and IL-1 signaling
-Neutrophils in MISC *spontaneously* form #NETS intravascularly (can’t be good…)
(Read on…)
Key points (#2)
- in MISC, Spike enters the blood (from the zonulin-mediated leak of GI reservoirs) —> spike:antibody complexes trigger #NET formation.
-IgA Spike immune complexes are most inflammatory.
-addressing GI Spike leak will be important for treatment for #MISC
- in MISC, Spike enters the blood (from the zonulin-mediated leak of GI reservoirs) —> spike:antibody complexes trigger #NET formation.
-IgA Spike immune complexes are most inflammatory.
-addressing GI Spike leak will be important for treatment for #MISC
• • •
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