Antihistamines should be near the top of your list of things to try for #LongCovid.

Yes, allergy and heartburn medication have provided *substantial* relief for many.

How does it work, and how do you get started? 🧵
1/ How does it work?

Histamine is in all of us, and plays a role in:
- Regulating sleep-wake cycles, temperature, and blood pressure
- Stimulating production of mucus and gastric acid
- Inflammation

It's in food, and it's also produced by your body. Too much is bad.
Enter Mast Cell Activation Syndrome (#MCAS).

In an allergic reaction, your immune system alerts your mast cells of an invader, and, among other things, they produce histamine to help clear things out.

Sometimes, they're too easily stimulated and flood the system with histamine.
Some #LongCovid symptoms, including tachycardia, low bp, flushing, shortness of breath, and congestion, overlap heavily with MCAS.

Another hint that MCAS could be at play: antihistamines can provide substantial relief.
2/ How to get started

There are some tangible things you can do today.

As always, this is not medical advice, and check with your doctor before making changes to your care.
2.1/ Avoid Triggers

Some potential culprits:
* Foods and additives (e.g. sausages, sulphites, corn syrup)
* Drinks (e.g. wine, cider)
* Artificial scents

Everyone can have different triggers. Pay close attention to try and identify yours.

More here: mcas.ie/wp-content/upl…
2.2/ Find antihistamines that work for you

Mast cells have H1 and H2 receptors, and you'll need to "block" both. You'll probably need some trial and error to find the right one for each. Based on the latest research, here are good starting points
- Zyrtec for H1
- Pepcid for H2
2.3/ Try a low-histamine diet

It's also important to lower the amount of histamine in your system ingested via food. Here are some to avoid:
- Packaged rice/pasta meals
- Fermented foods
- Strawberries
- Processed meats

More here: mastcell360.com/low-histamine-…
2.4/ Take supplements to improve your histamine processing.

Vitamin C, Zinc, Quercetin, Niacin, and Selenium are all worth considering

More in this great video by @gezmedinger and @DrTinaPeers here:
3/ More resources

A nice talk highlighting treatment strategies, including antihistamines
Antihistamines were among the top treatment in one of @longcovidpharmd's recent surveys (and was one of the most popular treatments, too)

A testimonial from a user that saw benefit (there are tons of these out there!)
4/ If you're thinking of trying antihistamines, you can use Eureka to see how it impacts your congestion, tachycardia, HRV, and more.

Plus, you'll be helping the community learn what works on who.

Click to get started today:
eurekahealth.com/plan/antihista…

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More from @EurekaHealthApp

Oct 12
Why is Brain Fog so common in #LongCovid (+#MECFS)?

Two giants of immunobiology and neuroscience, @virusesimmunity and @michelle_monje, just published a preprint that reviews the latest.

Here’s what you need to know 👇
First, it appears that multiple mechanisms conspire to cause Long Covid, and any given case might have its own particular combination.

Researchers are racing to confirm these mechanisms, so we can start working on cures.
1/ Respiratory inflammation --> central nervous system (CNS) inflammation

Some impacts:
a) Disrupted myelination: electrical impulses don’t fire as well
b) ⬇️ hippocampus cell growth: worse memory and mood
c) ⬆️ astrocyte reactivity: poor blood flow and reduced neurotransmitters
Read 11 tweets
Oct 10
Why is symptom tracking for #LongCovid or #MECFS so hard? 📈

It's invaluable to know how your condition is changing and if new treatments are helping.

But after talking to over 200 patients, almost nobody sticks with it.

Here’s how we could do better 🧵
1/ They don't actually help you get better 🤷

Symptom tracking should help you get better. If the tool isn’t providing insight into how treatments are impacting you and how you can get better, of course you’ll eventually stop using it.
2/ The questions are too vague 😶‍🌫️

“mild, moderate, severe” isn’t enough. Answers drift over time, and it won’t capture important, small changes.

More patient-informed rubrics are needed to track more accurately and consistently.

Here's a good example in our app: Image
Read 11 tweets
Sep 30
🌬 Breathwork is a not-so-hidden secret within the #LongCovid and #MECFS community, and has been described as “game-changing” and “the number 1 intervention I’ve tried”.

But how could it possibly be so helpful? How does it work? Let’s dive in.
1/ How does it work?

First off, this is not just “thinking your symptoms away”. It creates substantial changes to your physiology that can counteract some of the harm caused by Long Covid.
1.1/ Vagus Nerve (VN) Stimulation.

A disrupted VN (e.g. via persistent virus) can contribute to dysautonomia. Breathwork stimulates the VN, activating a “rest and digest” mode, potentially mitigating these symptoms and even decreasing inflammation.
Read 14 tweets
Sep 21
The twittersphere for #LongCovid and #MECFS is an information goldmine, but to get it you need to follow the right people.

Here are the top 9 accounts you should be following to stay up to speed with the latest. 👇
1/ @PutrinoLab

David Putrino runs a research group at Mt. Sinai, is a fierce patient advocate and a great science communicator. He makes sure patients are informed and involved in the latest research.
2/ @microbeminded2

Amy Proal is a tour de force in Long Covid research, and is the CSO of a new @polybioRF initiative focusing on viral persistence. Follow her to stay up to speed on the latest Long Covid research (and we'd recommend her interviews on Youtube as well).
Read 13 tweets

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