Dr Noor Bari Profile picture
Dec 2 12 tweets 2 min read
Case study of one family caught in the Strep outbreak on #PlagueIsland.

TL;DR

Asymptomatic carriage in kids.

Antibiotic shortage.

Adults symptomatic.
I have obtained permission to share these details. They are my extended family.
Case 1 ex prem. Started school this year. Fever. Malaise. No sore throat.

Focus of fever found by accident. There is a simple cure if you catch it in time. We didn’t
Case 2 otherwise healthy child, also started school this year but in the year above.

No fever, no sore throat, purulent tonsils found by GP on examination due to being a contact of case 1.
Case 3. Mum. Aching all over, feeling feverish, diarrhoea, no sore throat, some headaches. Not treated as yet. Still up and about looking after sick kids.
Case 4. Dad. Has been in bed for a couple of days feeling very unwell. Sore throat and “chills”(likely fever). GP said no need for antibiotics but deteriorating.
Forgot. Important detail. Case 3 has had a tonsillectomy in the past. Probably explains systemic infection without sore throat.
COVID tests have been ordered (for home delivery) but not arrived yet.

When I asked about antibiotics, the local chemist at the supermarket had run out. Tesco has run out of antibiotics.
No one in this cluster has had a rash (yet).
So, to summarise, there is a Strep bacterial outbreak. It’s likely it can be carried and spread asymptomatically. Could have atypical presentations. Can be serious.

Treatment shortage may be present.

Co-infection with COVID? A possibility.
Family believe Case 1 brought this latest plague home from school.

What a let down.
Considering strep is carried in the throat, I fully expect masks to help slow transmission together with hand hygiene.

Any reason why masks in schools have not been recommended to help slow strep outbreak? @UKHSA

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More from @NjbBari3

Dec 4
@DrKate_Miller Well… due to having a long career in emergency medicine… I think I have seen all the medical emergencies that don’t have immediately visible external signs diagnosed as anxiety, including physical trauma with internal bleeding.

Predominantly in women…
@DrKate_Miller In kids it’s not called “anxiety”… it’s labelled “faking it for attention”…

Nice, aren’t we…?
@DrKate_Miller Heart attacks, Guillaine Barre, MS, TB, sepsis (after which the patient died due to delay to treatment), ruptured spleen, perforated viscus, phaechromocytoma, subarachnoid haemorrhage… everything. Just all of it…
Read 5 tweets
Dec 4
There are 50 or more species of streptococcus. sciencedirect.com/topics/medicin…
Many Strep species live on or in us *all the time*.
Our immune systems will be familiar with common Streps and lockdown absolutely could not have stopped that process.

We would have to be gamma irradiated and in outer space to avoid Strep species. (Survival not guaranteed.)
Read 19 tweets
Dec 3
@1goodtern It’s not flawed, but it is one of many mechanisms I expect. This particular strep is invasive, so I expect it will produce toxin. The toxin has super-antigens, just like COVID. Can’t be a good thing to shake up that cocktail.
@1goodtern The cytokines are off too. Not sure how this will play into things. ncbi.nlm.nih.gov/pmc/articles/P…
Read 8 tweets
Dec 3
I don’t know how to explain it clearly enough.

There is a limit to what the human immune system can do.

Some bacteria and viruses *tend to be pathological*. They tend to kill. The risk benefit of exposure is weighted very unfavourably.
Group A streps come in many types. It has been difficult to work out why sometimes a patient gets invasive disease, and at other times not.

Both host and pathogen factors are being investigated.
On the pathogen side some work has been done to propose potential virulence associated antigens/gene activity. ncbi.nlm.nih.gov/pmc/articles/P…
Read 15 tweets
Dec 2
Somebody earned themselves an unfollow today…

It’s highly unlikely that anyone will be able to push me into unsafe working environments (at least not while I’m conscious and can run), but I really get annoyed by scientists that say sloppy OH&S is a“real world scenario”.
The real world, is what we make it. My real world was far, far better than that described in the mask RCT. It was made that way by responsive management. The results were really good.
I tweeted an article (non scientific) on it a while back, I will try to dig it up. We saw many COVID patients during those recurrent small outbreaks in Western Sydney in 2020 and 2021 and the rate of HCW infections and department closures was remarkably low.
Read 10 tweets
Dec 2
Smooth FM broadcast right now that this study will check various types of strength and aerobic exercise out to see if they help long COVID.

Well, they have ghost capillaries, mitochondria were stuffed up, and there is inflammation going on…

baker.edu.au/news/in-the-me…
Hard to exercise when your mitochondria are stuffed up.

Literally, you can’t make energy.

ifm.org/news-insights/…
Can exercise help regrow capillaries?

Yes.

Can exercise exercise suppress inflammation?

Yes, in moderation in *other conditions*.

BUT if something else is driving ongoing damage/inflammation, or if organs are already to damaged to regain function then you have a brick wall.
Read 7 tweets

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