Vancomycin is primarily effective against Gram positive bacteria ✅

No/clinically insignificant activity against most of the gram negative bacteria.🦠

Because of the large molecular size, vancomycin cannot penetrate the outer membrane of gram negative organisms. ❌
Exceptions:

📍In vitro activity against certain nongonococcal Neisseria species 🧫

📍Elizabethkingia meningoseptica that causes meningitis in newborn and immunosupressed. Evidence regarding the use is not clear though. 💉

#pharmacology #MedStudentTwitter #MedTwitter
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