Discover and read the best of Twitter Threads about #pharmacology

Most recents (15)

Yesterday, I completed my months-long quest to accurately identify all sci-fields emerging in WW other than the well-established Neuro ⬇️
For, it's been long since we noticed emerging scientific tangents that span diverse fields like: #ML, #Materials_Science, #Pharmacology, #Genomics, #Open_Hardware, etc
Awesome -- But, how does one possibly map all these frontiers without employing actual people to read and annotate dozens of hundreds of abstracts at a time?
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I'll be adding short important points which would hopefully help in remembering certain concepts during #PLAB preparation, to this thread🧵every now and then as I take them out from my scattered notes. Feel free to comment your tips and tricks which would help others, as well 👇
Please don't take any of these as medical advice 😂🙏. Real life stuff is much more nuanced. These are just clinchers for the sake of the exam.
1. Drug contraindications...
-Avoid BAN drugs in Asthma (Beta blockers, aspirin, NSAIDS) &
-DAMN drugs in diarrhoea (Diuretics, ACEIs, Metformin, NSAIDs)
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Rationale for #TDM

All TDM should be performed in the context of the clinical disease activity and severity -@IBDMD
Philosophy of #TDM
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SNEAK PREVIEW: Complete Path Enumeration (CPE) for CRM #dosefinding designs

Featuring a vignette for #Rstats package #precautionary update v0.2-3, currently under review by CRAN. 1/…
This demonstrates the feasibility of a programme I’ve set forth, for the ‘exact’ simulation of ANY dose-escalation design.

Influenced by @MarkusTriska‘s exacting perspective on ’exactness’, however, I now use the more precise term ‘MCSE-free’. 2/
@MarkusTriska ‘MCSE-free’ in turn alludes to the title of recent work by Thomas M. Braun, from which I adapt my application.

(Braun’s mean-field approach truly can be called ‘simulation-free’, whereas I DO simulate the trials—just without Monte Carlo error.) 3/
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Had a chance to read in detail this morning, and oh boy do I love this paper! While depression research and MOA of antidepressants are not really my thing now, the whole paradox of how the so-called SSRIs work is a major reason that I got into neuroscience to begin with.
First learned about this in neuropharmacology class as an undergrad @UT_Dallas in 1996 or so from a chapter in Basic Neurochemistry written by Alan Frazer and Julie Hensler. I was captivated by this paradox and decided to apply to @UTHealthSA #Pharmacology for grad school.
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For those interested in #cannabis #pharmacology review:… “in this short review we tried to shed light on the potential drug interactions of medicinal cannabis” 1/4 @division_55
“potential outcome of a drug interaction can be additive (1 + 1 = 2), synergistic (1 + 1 > 2), or antagonistic (1 + 1 < 2). Therefore, a drug interaction may lead to an enhanced drug response or modified or unexpected adverse reactions” 2/4
“Cannabis has been used in various forms as crude extracts or purified ingredients (different THC/cannabinoids ratios); therefore, drug interactions caused by cannabis depend not only on drugs involved but also chemical components/profiles of the cannabis preparations used” 3/4
Read 5 tweets
NEW #DTAT paper: What Were They Thinking? Pharmacologic priors implicit in a choice of 3+3 dose-escalation design

“The unexamined trial is not worth conducting.”

— Socrates 1/

This latest #DTAT paper @arXiv sets out to reverse-engineer the unstated (∴ unexamined!) pharmacologic intuitions that underlie the #trialsafety claim implicit in the decision to conduct a dose-escalation trial. 2/
Prior elicitation from doctors has never been easy, especially about #pharmacology or the future of the #Daleks: 3/

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ATTN #CBD stakeholders: @US_FDA today holding scientific conf. on CBD/other #cannabinoids. I'll be live tweeting throughout. Not sure we'll get much insight on immediate path forward for consumer products but I'll share noteworthy observations. Agenda:
I'll be paying particular attention to @DrAbernethyFDA's remarks at 9:05a (head of #FDA's #CBD Policy Working Group) and @DThrockmortonMD's keynote at 9:15a (one of Agency's principals for regulating R&D, manufacture & marketing of #cannabis & cannabis-derived #drug products).
And we're underway! First up is Kaveeta Vasisht, MD, PharmD. Associate Commissioner for Women’s
Health and Director, Office of Women’s Health, FDA. She's noting ubiquity of #CBD products in marketplace, many of which are targeted to #women.
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My journey to my #PhD program was an absolute #strugglebus. I graduated with a 2.75 GPA from @GeorgiaTech. Most grad applicants have a 3.5 or higher. #Yikes

I applied anyway 🤷🏾‍♀️🤷🏾‍♀️🤷🏾‍♀️ (I didn't get admitted into any programs - post bacc, M.S., or PhD) #AcademicChatter
Fortunately, my mentor @RaquelLieberman gave me the opportunity to work as a #research technician in her lab for 2 yrs to gain the experience I needed for grad school.

This is when I first started studying essential pathways that we could disrupt to kill disease causing bacteria
After working in her lab for almost 2 years..I reapplied again. This time I felt VERY confident I was ready for the #PhD.

I was denied admission to every single grad program I applied to (including the one I'm in now).
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What does getting a #PhD actually mean for me?

Here's a video I made last year for a general audience.
"Black Women in #STEM: What I do as a #PhD Student in #Pharmacology"

#GOBLUE @StemNoire @BlackInCardio @BlackInPhysio @BlackAFinSTEM

TLDR: Your ♥️ is regulated by an electrical impulse that travels throughout the ♥️. When this electrical signal is disrupted, this causes your ♥️ to beat irregularly (arrhythmia) & ineffectively pump blood throughout your can imagine that this isn't good 😬.
This irregular heart beat can cause your ♥️ to stop beating entirely = #suddencardiacdeath 🪦! In @EphysWiz's lab, my #PhD focuses on developing a therapy that can correct disrupted electrical activity of the ♥️ to restore healthy heart function. @BlackInCardio #STEMNoire
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"Further validation of the affective bias test for predicting antidepressant and pro-depressant risk: effects of pharmacological and social manipulations in male and female rats" @Dr_Hinch @doctmcgee…
Summary: #pharmacology #affectivebias #depression #animalmodels #affectivestate #malesandfemales #ABT
The need for a reliable and #translational tool measuring emotional behaviours in animals that possessing robust validity is unquestionably important but 1/
but very challenging to achieve. Commonly used assays are generally lacking in at least one aspect of #validity and do not fully translate into #clinical work. In this paper, the affective bias test (ABT) has demonstrated to reliably detect both positive 2/
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To the newly minted MS3s starting on the wards, here’s a running list of my most commonly encountered brand name meds I wish I knew day one. 💊💊💊#MedStudentTwitter #MedEd #Pharmacology 1/n
🦠 Antimicrobials
Augmentin = amoxicillin/clavulanic acid
Zosyn = pipercillin/tazobactam
Invanz = ertapenem
Flagyl = metronidazole
Bactrim = TMP-SMX
Diflucan = fluconazole
Eliquis = apixaban
Pradaxa = dabigatran
Xarelto = rivaroxaban
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I listen to ~90 #Podcasts on a (semi) regular basis. Let me give you a rundown of ALL of them and why you should listen to some amazing #FOAMed, especially for all the new #EmergencyMedicine interns. #FOAMed #MedEd #medtwitter
First of all, you need a good podcast app. I absolutely love Downcast. Great app, gives you more control over playback, downloading, and allows you to categorize your podcasts into playlists (picture 2). This is where you get to customize your #FOAMed experience! #medtwitter
In no particular order,

- Anesthesia and Critical Care Reviews and Commentary (ACCRAC). Great insight into Crit Care from an anesthesia perspective. Coming from EM, this is great to listen to- much different from my day-to-day! #FOAMed #FOAMcc #CriticalCare
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After a jam-packed 2 days at #SciOut18🌪(thx @ASBMB & @rockedu_!) it was time to reflect! 🤔 Reflection is so important, but it can be hard to find ⏰ to really just think! 💭 Some of my thoughts 👉
#365DaysOfScience #biochemistry #scicomm #sciout #science person looking thoughtful in front of mirrornotebook pagenotebook pagenotebook page
What’s inside? 🧐 It’s FORMAMIDE! 🤗 Formally removing RNA’s form with formamide! 🤓 FORMAMIDE in loading buffer breaks up & replaces the bonds between bases holding RNA's shape together 👇
#365DaysOfScience #biochemistry #scicomm #lifeinthelab #science person looking through safety goggles with formamide drawn on themformamide RNA denaturant explanation
Bring on the heat! 🔥 To help denaturants get to the huddling hydrophobic bases, we add heat ♨️ 👉 gives molecules more energy so they can “pull apart” more easily ⏩ easier access 👍 More 👇
#365DaysOfScience #biochemistry #scicomm #lifeinthelab #science person putting tube in heating block
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