Discover and read the best of Twitter Threads about #pharmacology
Most recents (24)
Interesting to see anti #obesity and #diabetes #medication management from the perspective of PharmDs
I'm always pro-collaborative care!
Here are some learning points and fact checks:
#AACE2023 #endocrine #endocrinology #pharmacology
1/
I'm always pro-collaborative care!
Here are some learning points and fact checks:
#AACE2023 #endocrine #endocrinology #pharmacology
1/
- "Tirzepatide is a dual agonist"
👉It ↑GIP activity but GLP-1R agonism is less than that of endogenous GLP-1
- "Hypoglycemia is not a concern if you're not on insulin"
👉Risk of hypoglycemia ~1.4% vs. 0.2% in placebo in SURMOUNT-1
nejm.org/doi/full/10.10…
2/
👉It ↑GIP activity but GLP-1R agonism is less than that of endogenous GLP-1
- "Hypoglycemia is not a concern if you're not on insulin"
👉Risk of hypoglycemia ~1.4% vs. 0.2% in placebo in SURMOUNT-1
nejm.org/doi/full/10.10…
2/
- "In this pt with uncontrolled #diabetes, A1c 7.4, we decreased glargine by 10% [when we started tirzepatide]"
👉 Not sure where the evidence is here, but the SURPASS-5 trial protocol reduced basal by 20% in participants with baseline A1c<8
jamanetwork.com/journals/jama/…
3/
👉 Not sure where the evidence is here, but the SURPASS-5 trial protocol reduced basal by 20% in participants with baseline A1c<8
jamanetwork.com/journals/jama/…
3/
Sotalol is a _____ antiarrhythmic agent
Video from Classify Rx 📱 onelink.to/classifyp
Vancomycin is primarily effective against Gram positive bacteria ✅
No/clinically insignificant activity against most of the gram negative bacteria.🦠
Because of the large molecular size, vancomycin cannot penetrate the outer membrane of gram negative organisms. ❌
No/clinically insignificant activity against most of the gram negative bacteria.🦠
Because of the large molecular size, vancomycin cannot penetrate the outer membrane of gram negative organisms. ❌
Exceptions:
📍In vitro activity against certain nongonococcal Neisseria species 🧫
📍Elizabethkingia meningoseptica that causes meningitis in newborn and immunosupressed. Evidence regarding the use is not clear though. 💉
#pharmacology #MedStudentTwitter #MedTwitter
📍In vitro activity against certain nongonococcal Neisseria species 🧫
📍Elizabethkingia meningoseptica that causes meningitis in newborn and immunosupressed. Evidence regarding the use is not clear though. 💉
#pharmacology #MedStudentTwitter #MedTwitter
Screenshot from Classify Rx 📱 onelink.to/classifyp
Dexamethasone is a _____ acting steroid
Dexamethasone has no mineralocorticoid activity
New article out now regarding the pharmacology of #psilocybin analogues including other compounds found in psilocybin-containing mushrooms, their active metabolites, and 4-acetoxy derivatives.
pubs.acs.org/doi/10.1021/ac…
#pharmacology #psychedelics #aeruginascin #baeocystin
pubs.acs.org/doi/10.1021/ac…
#pharmacology #psychedelics #aeruginascin #baeocystin
This was truly an amazing team effort by many folks from @usonainstitute, @CaaMTechInc, @christophestove, Manke lab, Hulley lab, and NIDA IRP DDRU.
Keep an eye out for many more publications from us investigating the #pharmacology of #psychedelics !
Keep an eye out for many more publications from us investigating the #pharmacology of #psychedelics !
Oh and I certainly can't forget to thank the NIMH PDSP for their role in these projects!
📍Hydroxyzine is a first-generation H1 antagonist
📌Sedative action is pronounced
#pharmacology #MedStudentTwitter #MedTwitter
📌Sedative action is pronounced
#pharmacology #MedStudentTwitter #MedTwitter
📍Cetirizine is a second generation H1 antagonist
📌An active metabolite of hydroxyzine
📌Less sedative action when compared to hydroxyzine but has higher sedative action than most of the other second generation H1 antagonists
📌An active metabolite of hydroxyzine
📌Less sedative action when compared to hydroxyzine but has higher sedative action than most of the other second generation H1 antagonists
📍Levocetirizine is the active enantiomer of cetirizine
📌More potent than cetirizine and can be used at half the dose of cetirizine with lesser sedation
📌More potent than cetirizine and can be used at half the dose of cetirizine with lesser sedation
They have opposite effect on potassium levels and balance out each other ✌️
#pharmacology #MedStudentTwitter #MedTwitter
#pharmacology #MedStudentTwitter #MedTwitter
Which of the following will cause hyperkalemia ?
Higher incidence of cough is seen with
Which of the following is a cardioselective beta blocker ?
Screenshots from Classify Rx 📱 onelink.to/classifyp
Which of the following is a prodrug ?
Which of the following has no mineralocorticoid activity ?
Yesterday, I completed my months-long quest to accurately identify all sci-fields emerging in WW other than the well-established Neuro ⬇️
For, it's been long since we noticed emerging scientific tangents that span diverse fields like: #ML, #Materials_Science, #Pharmacology, #Genomics, #Open_Hardware, etc
Awesome -- But, how does one possibly map all these frontiers without employing actual people to read and annotate dozens of hundreds of abstracts at a time?
I'll be adding short important points which would hopefully help in remembering certain concepts during #PLAB preparation, to this thread🧵every now and then as I take them out from my scattered notes. Feel free to comment your tips and tricks which would help others, as well 👇
Please don't take any of these as medical advice 😂🙏. Real life stuff is much more nuanced. These are just clinchers for the sake of the exam.
#PLAB
#PLAB
1. Drug contraindications...
-Avoid BAN drugs in Asthma (Beta blockers, aspirin, NSAIDS) &
-DAMN drugs in diarrhoea (Diuretics, ACEIs, Metformin, NSAIDs)
#PLAB
-Avoid BAN drugs in Asthma (Beta blockers, aspirin, NSAIDS) &
-DAMN drugs in diarrhoea (Diuretics, ACEIs, Metformin, NSAIDs)
#PLAB
1/🧵
What's your favorite anti-seizure medication (ASM)?
If you said levetiracetam (LEV), you're not alone.
Why do so many #neurologists ♥️ LEV? A #tweetorial.
#MedStudentTwitter #NeuroTwitter #MedTwitter @MedTweetorials
What's your favorite anti-seizure medication (ASM)?
If you said levetiracetam (LEV), you're not alone.
Why do so many #neurologists ♥️ LEV? A #tweetorial.
#MedStudentTwitter #NeuroTwitter #MedTwitter @MedTweetorials
2/
What's so good about LEV? First, some #pharmacology:
✅ Fast PO absorption
✅ 1:1 PO:IV 💉
✅ Few med interactions
✅ Can load for status epilepticus
pubmed.ncbi.nlm.nih.gov/31029217/
What's so good about LEV? First, some #pharmacology:
✅ Fast PO absorption
✅ 1:1 PO:IV 💉
✅ Few med interactions
✅ Can load for status epilepticus
pubmed.ncbi.nlm.nih.gov/31029217/
3/
And lots of clinical uses:
1⃣ Focal and generalized seizures
2⃣ From 👶 to 🧓
3⃣ Often used in 🤰 (category C): pubmed.ncbi.nlm.nih.gov/28472982/
4⃣ Good for status epilepticus (60 mg/kg, up to 4500 mg) - similar efficacy to phenytoin & valproic acid:
pubmed.ncbi.nlm.nih.gov/32203691/
And lots of clinical uses:
1⃣ Focal and generalized seizures
2⃣ From 👶 to 🧓
3⃣ Often used in 🤰 (category C): pubmed.ncbi.nlm.nih.gov/28472982/
4⃣ Good for status epilepticus (60 mg/kg, up to 4500 mg) - similar efficacy to phenytoin & valproic acid:
pubmed.ncbi.nlm.nih.gov/32203691/
Rationale for #TDM
All TDM should be performed in the context of the clinical disease activity and severity -@IBDMD
All TDM should be performed in the context of the clinical disease activity and severity -@IBDMD
Philosophy of #TDM
Daily Bookmarks to GAVNet 08/05/2021 greeneracresvaluenetwork.wordpress.com/2021/08/05/dai…
The hunt for red fluorescent proteins
nature.com/articles/d4158…
#FluorescentProteins #BiologicalImaging #CellularStudy
nature.com/articles/d4158…
#FluorescentProteins #BiologicalImaging #CellularStudy
New ‘Universal Switch’ Lets Scientists Fine-Tune Gene Therapy
singularityhub.com/2021/08/03/new…
#GeneTherapy #GeneExpression #pharmacology
singularityhub.com/2021/08/03/new…
#GeneTherapy #GeneExpression #pharmacology
SNEAK PREVIEW: Complete Path Enumeration (CPE) for CRM #dosefinding designs
Featuring a vignette for #Rstats package #precautionary update v0.2-3, currently under review by CRAN. 1/
precisionmethods.guru/DTAT/CPE/MCSE-…
Featuring a vignette for #Rstats package #precautionary update v0.2-3, currently under review by CRAN. 1/
precisionmethods.guru/DTAT/CPE/MCSE-…
This demonstrates the feasibility of a programme I’ve set forth, for the ‘exact’ simulation of ANY dose-escalation design.
Influenced by @MarkusTriska‘s exacting perspective on ’exactness’, however, I now use the more precise term ‘MCSE-free’. 2/
Influenced by @MarkusTriska‘s exacting perspective on ’exactness’, however, I now use the more precise term ‘MCSE-free’. 2/
@MarkusTriska ‘MCSE-free’ in turn alludes to the title of recent work by Thomas M. Braun, from which I adapt my application.
(Braun’s mean-field approach truly can be called ‘simulation-free’, whereas I DO simulate the trials—just without Monte Carlo error.) 3/
(Braun’s mean-field approach truly can be called ‘simulation-free’, whereas I DO simulate the trials—just without Monte Carlo error.) 3/
BOOM!! BOOM and BOOM! cell.com/cell/fulltext/…
Had a chance to read in detail this morning, and oh boy do I love this paper! While depression research and MOA of antidepressants are not really my thing now, the whole paradox of how the so-called SSRIs work is a major reason that I got into neuroscience to begin with.
First learned about this in neuropharmacology class as an undergrad @UT_Dallas in 1996 or so from a chapter in Basic Neurochemistry written by Alan Frazer and Julie Hensler. I was captivated by this paradox and decided to apply to @UTHealthSA #Pharmacology for grad school.
For those interested in #cannabis #pharmacology review: ncbi.nlm.nih.gov/pmc/articles/P… “in this short review we tried to shed light on the potential drug interactions of medicinal cannabis” 1/4 @division_55
“potential outcome of a drug interaction can be additive (1 + 1 = 2), synergistic (1 + 1 > 2), or antagonistic (1 + 1 < 2). Therefore, a drug interaction may lead to an enhanced drug response or modified or unexpected adverse reactions” 2/4
“Cannabis has been used in various forms as crude extracts or purified ingredients (different THC/cannabinoids ratios); therefore, drug interactions caused by cannabis depend not only on drugs involved but also chemical components/profiles of the cannabis preparations used” 3/4
NEW #DTAT paper: What Were They Thinking? Pharmacologic priors implicit in a choice of 3+3 dose-escalation design arxiv.org/abs/2012.05301
“The unexamined trial is not worth conducting.”
— Socrates 1/
“The unexamined trial is not worth conducting.”
— Socrates 1/
This latest #DTAT paper @arxiv sets out to reverse-engineer the unstated (∴ unexamined!) pharmacologic intuitions that underlie the #trialsafety claim implicit in the decision to conduct a dose-escalation trial. 2/
Prior elicitation from doctors has never been easy, especially about #pharmacology or the future of the #Daleks: 3/
ATTN #CBD stakeholders: @US_FDA today holding scientific conf. on CBD/other #cannabinoids. I'll be live tweeting throughout. Not sure we'll get much insight on immediate path forward for consumer products but I'll share noteworthy observations. Agenda: bit.ly/3pHXU8V
I'll be paying particular attention to @DrAbernethyFDA's remarks at 9:05a (head of #FDA's #CBD Policy Working Group) and @DThrockmortonMD's keynote at 9:15a (one of Agency's principals for regulating R&D, manufacture & marketing of #cannabis & cannabis-derived #drug products).
My journey to my #PhD program was an absolute #strugglebus. I graduated with a 2.75 GPA from @GeorgiaTech. Most grad applicants have a 3.5 or higher. #Yikes
I applied anyway 🤷🏾♀️🤷🏾♀️🤷🏾♀️ (I didn't get admitted into any programs - post bacc, M.S., or PhD) #AcademicChatter
I applied anyway 🤷🏾♀️🤷🏾♀️🤷🏾♀️ (I didn't get admitted into any programs - post bacc, M.S., or PhD) #AcademicChatter
Fortunately, my mentor @RaquelLieberman gave me the opportunity to work as a #research technician in her lab for 2 yrs to gain the experience I needed for grad school.
This is when I first started studying essential pathways that we could disrupt to kill disease causing bacteria
This is when I first started studying essential pathways that we could disrupt to kill disease causing bacteria
After working in her lab for almost 2 years..I reapplied again. This time I felt VERY confident I was ready for the #PhD.
I was denied admission to every single grad program I applied to (including the one I'm in now).
I was denied admission to every single grad program I applied to (including the one I'm in now).
What does getting a #PhD actually mean for me?
Here's a video I made last year for a general audience.
"Black Women in #STEM: What I do as a #PhD Student in #Pharmacology"
#GOBLUE @StemNoire @BlackInCardio @BlackInPhysio @BlackAFinSTEM
Here's a video I made last year for a general audience.
"Black Women in #STEM: What I do as a #PhD Student in #Pharmacology"
#GOBLUE @StemNoire @BlackInCardio @BlackInPhysio @BlackAFinSTEM
TLDR: Your ♥️ is regulated by an electrical impulse that travels throughout the ♥️. When this electrical signal is disrupted, this causes your ♥️ to beat irregularly (arrhythmia) & ineffectively pump blood throughout your body...you can imagine that this isn't good 😬.
This irregular heart beat can cause your ♥️ to stop beating entirely = #suddencardiacdeath 🪦! In @EphysWiz's lab, my #PhD focuses on developing a therapy that can correct disrupted electrical activity of the ♥️ to restore healthy heart function. @BlackInCardio #STEMNoire
"Further validation of the affective bias test for predicting antidepressant and pro-depressant risk: effects of pharmacological and social manipulations in male and female rats" @Dr_Hinch @doctmcgee link.springer.com/article/10.100…
Summary: #pharmacology #affectivebias #depression #animalmodels #affectivestate #malesandfemales #ABT
The need for a reliable and #translational tool measuring emotional behaviours in animals that possessing robust validity is unquestionably important but 1/
The need for a reliable and #translational tool measuring emotional behaviours in animals that possessing robust validity is unquestionably important but 1/
To the newly minted MS3s starting on the wards, here’s a running list of my most commonly encountered brand name meds I wish I knew day one. 💊💊💊#MedStudentTwitter #MedEd #Pharmacology 1/n
🦠 Antimicrobials
Augmentin = amoxicillin/clavulanic acid
Zosyn = pipercillin/tazobactam
Invanz = ertapenem
Flagyl = metronidazole
Bactrim = TMP-SMX
Diflucan = fluconazole
Augmentin = amoxicillin/clavulanic acid
Zosyn = pipercillin/tazobactam
Invanz = ertapenem
Flagyl = metronidazole
Bactrim = TMP-SMX
Diflucan = fluconazole
🩸Anticoagulation
Eliquis = apixaban
Pradaxa = dabigatran
Xarelto = rivaroxaban
Eliquis = apixaban
Pradaxa = dabigatran
Xarelto = rivaroxaban
I listen to ~90 #Podcasts on a (semi) regular basis. Let me give you a rundown of ALL of them and why you should listen to some amazing #FOAMed, especially for all the new #EmergencyMedicine interns. #FOAMed #MedEd #medtwitter
First of all, you need a good podcast app. I absolutely love Downcast. Great app, gives you more control over playback, downloading, and allows you to categorize your podcasts into playlists (picture 2). This is where you get to customize your #FOAMed experience! #medtwitter
In no particular order,
- Anesthesia and Critical Care Reviews and Commentary (ACCRAC). Great insight into Crit Care from an anesthesia perspective. Coming from EM, this is great to listen to- much different from my day-to-day! #FOAMed #FOAMcc #CriticalCare
- Anesthesia and Critical Care Reviews and Commentary (ACCRAC). Great insight into Crit Care from an anesthesia perspective. Coming from EM, this is great to listen to- much different from my day-to-day! #FOAMed #FOAMcc #CriticalCare
