Thread by @nick_krontiris

In this one, exogenous testosterone administration was found to alter the metabolome in such a way that lipid substrates were preferentially utilized over amino acids, something that was in turn associated with attenuated muscle proteolysis during a severe energy deficit.

- Testosterone administration altered androgenic steroid, acylcarnitine, and amino acid metabolites during severe energy deficit compared to the placebo group.

- During the recovery period, when testosterone was not administered and the severe energy deficit had ended, many of these changes reversed.

- Changes in lean mass during the severe energy deficit were related to changes in androgenic steroids and acylcarnitines, and inversely related to changes in amino acid metabolites.

- "Thus, these data suggest doses of testosterone enanthate (200 mg/wk in sesame oil), administered weekly during severe energy deficit altered serum metabolomic signatures in a manner corresponding to increases in lean mass."

Metabolomics of testosterone enanthate administration during severe-energy deficit (open access)

doi.org/10.1007/s11306…

#men #hormones #testosterone